Upstream Bio (UPB) EBITDA Margin (2023 - 2026)
Upstream Bio's quarterly EBITDA Margin came in at 4218.09% in Q1 2026, up 143792.0% year-on-year from N/an in Q1 2025, and up 38.97% quarter-over-quarter from 6911.23% in Q4 2025.
Upstream Bio has reported EBITDA Margin for 4 years, with the latest figure at 4218.09% in Q1 2026.
- For the quarter ending Q1 2026, EBITDA Margin rose 143792.0% year-over-year to 4218.09%; the trailing twelve-month figure through Mar 2026 stood at 5176.49% (down 104914.0% YoY), and the FY2025 full-year result was 5618.82%, down 233763.0% from the prior year.
- EBITDA Margin for Q1 2026 stood at 4218.09%, up from 6911.23% in the prior quarter.
- The five-year high for EBITDA Margin was 1511.43% in Q3 2023, with the low at 6911.23% in Q4 2025.
- Average EBITDA Margin over 4 years is 4085.84%, with a median of 4218.09% recorded in 2026.
- Year-over-year, EBITDA Margin plunged 331023 bps in 2025 and surged 143792 bps in 2026.
- Tracing UPB's EBITDA Margin over 4 years: stood at 3184.44% in 2023, then slumped by 35 bps to 4293.31% in 2024, then slumped by 61 bps to 6911.23% in 2025, then jumped by 39 bps to 4218.09% in 2026.
- The last three EBITDA Margin figures came in at 4218.09% (Q1 2026), 6911.23% (Q4 2025), and 5539.39% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 18.35% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 17.24% |
| 10 | Upstream Bio | 454.22 Mn | 454.22 Mn | -3.94 Mn | -4,218.09% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -4,218.09% |
| Dec 31, 2025 | -6,911.23% |
| Sep 30, 2025 | -5,539.39% |
| Jun 30, 2025 | -4,732.87% |
| Mar 31, 2025 | -5,656.01% |
| Dec 31, 2024 | -4,293.31% |
| Sep 30, 2024 | -3,112.52% |
| Jun 30, 2024 | -3,439.22% |
| Mar 31, 2024 | -2,345.78% |
| Dec 31, 2023 | -3,184.44% |
| Sep 30, 2023 | -1,511.43% |