Enanta Pharmaceuticals (ENTA) Operating Margin (2012 - 2026)
Enanta Pharmaceuticals' Operating Margin came in at -120.04% for fiscal Q3 2026 (quarter ended Jun 30, 2026), down 16.87 percentage points from -103.16% a year earlier and down 50.96 percentage points from the prior quarter.
Enanta Pharmaceuticals (ENTA) Operating Margin (2012 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Enanta Pharmaceuticals reported Operating Margin of -89.99%, up 59.40 percentage points year-over-year; for FY2025 (ended Sep 30, 2025), it was -130.65%, up 49.27 percentage points from FY2024.
- Operating Margin carries a five-year change of -96.66 percentage points (FY2020 to FY2025).
- Going back by fiscal year, Operating Margin was -179.92% in FY2024 (-6.69 pp), -173.23% in FY2023 (-29.50 pp), -143.74% in FY2022 (-30.86 pp) and -112.88% in FY2021 (-78.88 pp).
- The five-year range for quarterly Operating Margin is -221.70% (fiscal Q2 2023) to -60.45% (fiscal Q1 2026).
- Year-over-year, Operating Margin increased in six of the last eight quarters, with an average year-over-year change of +39.16 percentage points.
- The fastest year-over-year change in Operating Margin over five years came in fiscal Q2 2026 (a gain of 95.25 percentage points), and the weakest in fiscal Q1 2022 (a drop of 71.24 percentage points).
- Business Quant data shows ENTA's Operating Margin at -69.07% (Q2 2026), -60.45% (Q1 2026) and -121.56% (Q4 2025) in the three fiscal quarters before Q3 2026.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Enanta Pharmaceuticals | 367.20 Mn | -360.79 Mn | - | -120.04% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -120.04% |
| Mar 31, 2026 | -69.07% |
| Dec 31, 2025 | -60.45% |
| Sep 30, 2025 | -121.56% |
| Jun 30, 2025 | -103.16% |
| Mar 31, 2025 | -164.32% |
| Dec 31, 2024 | -138.82% |
| Sep 30, 2024 | -204.38% |
| Jun 30, 2024 | -134.58% |
| Mar 31, 2024 | -192.13% |
| Dec 31, 2023 | -193.78% |
| Sep 30, 2023 | -163.90% |
| Jun 30, 2023 | -194.33% |
| Mar 31, 2023 | -221.70% |
| Dec 31, 2022 | -127.25% |
| Sep 30, 2022 | -133.13% |
| Jun 30, 2022 | -167.05% |
| Mar 31, 2022 | -180.85% |
| Dec 31, 2021 | -109.99% |
| Sep 30, 2021 | -143.06% |
Enanta Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=ENTA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "ENTA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=ENTA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();