Castle Biosciences (CSTL) Operating Margin (2018 - 2026)
Castle Biosciences (CSTL) posted Operating Margin of 22.0% for Q1 2026, down 400.12% sequentially from 4.4% in Q4 2025, and up 974.0% YoY from 2.05% in Q1 2025.
Castle Biosciences (CSTL) Operating Margin (2018 - 2026) Analysis & Trends
Castle Biosciences (CSTL) has 9 years of Operating Margin data on file, last reported at 22.0% in Q1 2026.
- Quarterly Operating Margin rose 974.0% year-over-year to 22.0% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 9.79% (down 582.0% YoY) and the FY2025 annual result came in at 12.44%, down 1505.0% from the prior year.
- Operating Margin eased to 22.0% in Q1 2026 per CSTL's latest filing, from 4.4% in the prior quarter.
- The five-year high for Operating Margin was 5.92% in Q3 2024, with the low at 91.3% in Q1 2022.
- Average Operating Margin over 5 years is 24.96%, with a median of 11.4% recorded in 2022.
- Year-over-year, Operating Margin plunged 7252 bps in 2022 and soared 6749 bps in 2024.
- Castle Biosciences' Operating Margin stood at 59.55% in 2022, then surged by 86 bps to 8.56% in 2023, then soared by 155 bps to 4.69% in 2024, then slumped by 194 bps to 4.4% in 2025, then slumped by 400 bps to 22.0% in 2026.
- Business Quant data shows CSTL's Operating Margin at 22.0% in Q1 2026, 4.4% in Q4 2025, and 8.19% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 31,055.11 Bn | 31,054.65 Bn | 1.11 Bn | -3.71% |
| 2 | Thermo Fisher Scientific | 191.02 Bn | 187.77 Bn | 7.74 Bn | 16.93% |
| 3 | Danaher | 137.16 Bn | 131.47 Bn | 3.59 Bn | 22.58% |
| 4 | Idexx Laboratories | 42.82 Bn | 42.62 Bn | 722.74 Mn | 31.78% |
| 5 | Natera | 39.09 Bn | 37.99 Bn | 696.04 Mn | -13.42% |
| 6 | Agilent Technologies | 37.61 Bn | 35.81 Bn | 990.00 Mn | 21.74% |
| 7 | Iqvia Holdings | 34.23 Bn | 32.25 Bn | 1.36 Bn | 12.38% |
| 8 | Illumina | 28.14 Bn | 26.98 Bn | 721.00 Mn | 19.16% |
| 9 | Mettler Toledo International | 26.40 Bn | 26.33 Bn | 555.82 Mn | 25.23% |
| 10 | Castle Biosciences | 738.56 Mn | 476.84 Mn | 63.15 Mn | -22.00% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -22.00% |
| Dec 31, 2025 | -4.40% |
| Sep 30, 2025 | -8.19% |
| Jun 30, 2025 | -4.93% |
| Mar 31, 2025 | -31.74% |
| Dec 31, 2024 | 4.69% |
| Sep 30, 2024 | 5.92% |
| Jun 30, 2024 | 5.76% |
| Mar 31, 2024 | -7.50% |
| Dec 31, 2023 | -8.56% |
| Sep 30, 2023 | -15.68% |
| Jun 30, 2023 | -42.20% |
| Mar 31, 2023 | -74.99% |
| Dec 31, 2022 | -59.55% |
| Sep 30, 2022 | -58.19% |
| Jun 30, 2022 | -11.40% |
| Mar 31, 2022 | -91.30% |
| Dec 31, 2021 | -60.59% |
| Sep 30, 2021 | -50.33% |
| Jun 30, 2021 | -38.71% |