Castle Biosciences (CSTL) Operating Margin (2018 - 2026)
Castle Biosciences' (CSTL) quarterly Operating Margin came in at 2.96% in Q2 2026, up 197.0% year-over-year from 1.0% in Q2 2025, and up 86.52% quarter-over-quarter from 22.0% in Q1 2026.
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Castle Biosciences (CSTL) Operating Margin (2018 - 2026) Analysis & Trends
Castle Biosciences has disclosed Operating Margin across 9 years of filings, most recently posting 2.96% for Q2 2026.
- In Q2 2026, Operating Margin rose 197.0% year-over-year to 2.96%; the TTM figure through Jun 2026 stood at 8.99% (down 233.0% YoY), while the FY2025 annual figure was 12.44%, down 1505.0% from the prior year.
- Operating Margin came in at 2.96% for Q2 2026 at Castle Biosciences, up from 22.0% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 5.92% in Q3 2024 to a low of 91.3% in Q1 2022.
- Average Operating Margin over 5 years is 23.73%, with a median of 9.98% recorded in 2022.
- Year-over-year, Operating Margin sank 7252 bps in 2022 and soared 6749 bps in 2024.
- Over 5 years, Operating Margin stood at 59.55% in 2022, then surged by 86 bps to 8.56% in 2023, then soared by 155 bps to 4.69% in 2024, then tumbled by 194 bps to 4.4% in 2025, then surged by 33 bps to 2.96% in 2026.
- Per Business Quant data, the three most recent Operating Margin figures were 2.96% in Q2 2026, 22.0% in Q1 2026, and 4.4% in Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Natera | 53.05 Bn | 51.95 Bn | 486.15 Mn | -10.07% |
| 2 | Quest Diagnostics | 27.19 Bn | 26.87 Bn | 1.03 Bn | 15.08% |
| 3 | Labcorp Holdings | 25.93 Bn | 25.81 Bn | 1.11 Bn | 12.10% |
| 4 | Guardant Health | 23.97 Bn | 22.91 Bn | 219.03 Mn | -38.55% |
| 5 | Tempus AI | 13.64 Bn | 12.82 Bn | 274.25 Mn | -19.85% |
| 6 | Caris Life Sciences | 8.47 Bn | 7.68 Bn | 182.38 Mn | 10.21% |
| 7 | Sotera Health | 5.35 Bn | 4.99 Bn | 177.96 Mn | 34.17% |
| 8 | BillionToOne | 4.96 Bn | 4.41 Bn | 77.11 Mn | 5.03% |
| 9 | Adaptive Biotechnologies | 4.55 Bn | 4.21 Bn | 51.39 Mn | -22.04% |
| 10 | Castle Biosciences | 1.08 Bn | 811.36 Mn | 79.85 Mn | -2.96% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -2.96% |
| Mar 31, 2026 | -22.00% |
| Dec 31, 2025 | -4.40% |
| Sep 30, 2025 | -8.19% |
| Jun 30, 2025 | -4.93% |
| Mar 31, 2025 | -31.74% |
| Dec 31, 2024 | 4.69% |
| Sep 30, 2024 | 5.92% |
| Jun 30, 2024 | 5.76% |
| Mar 31, 2024 | -7.50% |
| Dec 31, 2023 | -8.56% |
| Sep 30, 2023 | -15.68% |
| Jun 30, 2023 | -42.20% |
| Mar 31, 2023 | -74.99% |
| Dec 31, 2022 | -59.55% |
| Sep 30, 2022 | -58.19% |
| Jun 30, 2022 | -11.40% |
| Mar 31, 2022 | -91.30% |
| Dec 31, 2021 | -60.59% |
| Sep 30, 2021 | -50.33% |
API Access
Castle Biosciences Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "CSTL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();