Castle Biosciences (CSTL) Gross Margin (2018 - 2026)
Castle Biosciences' (CSTL) quarterly Gross Margin came in at 75.46% in Q1 2026, down 592.0% year-on-year from 15.34% in Q1 2025, and down 4.42% quarter-over-quarter from 78.95% in Q4 2025.
Castle Biosciences (CSTL) Gross Margin (2018 - 2026) Analysis & Trends
Castle Biosciences has disclosed Gross Margin across 9 years of filings, most recently posting 75.46% for Q1 2026.
- Gross Margin for Q1 2026 came in at 75.46%, down 592.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 77.88% (down 405.0% YoY), and the FY2025 annual result was 79.37%, down 250.0% from the prior year.
- Gross Margin came in at 75.46% for Q1 2026 at Castle Biosciences, down from 78.95% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 83.31% in Q2 2024 to a low of 75.17% in Q4 2022.
- The 5-year median for Gross Margin is 78.95% (2025), against an average of 79.04%.
- Across the five-year window, Gross Margin sank 886 bps in 2022 and soared 604 bps in 2023, its largest moves.
- Castle Biosciences' Gross Margin stood at 75.17% in 2022, then grew by 8 bps to 81.21% in 2023, then increased by 0 bps to 81.25% in 2024, then slipped by 3 bps to 78.95% in 2025, then retreated by 4 bps to 75.46% in 2026.
- The last three Gross Margin figures came in at 75.46% (Q1 2026), 78.95% (Q4 2025), and 77.48% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 30,529.42 Bn | 30,528.96 Bn | 1.11 Bn | 87.77% |
| 2 | Thermo Fisher Scientific | 183.75 Bn | 180.50 Bn | 7.74 Bn | 70.37% |
| 3 | Danaher | 133.13 Bn | 127.43 Bn | 3.59 Bn | 60.34% |
| 4 | Idexx Laboratories | 46.14 Bn | 45.94 Bn | 722.74 Mn | 63.35% |
| 5 | Agilent Technologies | 38.20 Bn | 36.39 Bn | 990.00 Mn | 53.95% |
| 6 | Natera | 31.50 Bn | 30.40 Bn | 696.04 Mn | 99.91% |
| 7 | Iqvia Holdings | 31.34 Bn | 29.36 Bn | 1.36 Bn | 32.64% |
| 8 | Illumina | 24.51 Bn | 23.36 Bn | 721.00 Mn | 66.09% |
| 9 | Mettler Toledo International | 23.53 Bn | 23.47 Bn | 555.82 Mn | 58.68% |
| 10 | Castle Biosciences | 629.76 Mn | 368.04 Mn | 63.15 Mn | 75.46% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 75.46% |
| Dec 31, 2025 | 78.95% |
| Sep 30, 2025 | 77.48% |
| Jun 30, 2025 | 79.55% |
| Mar 31, 2025 | 81.38% |
| Dec 31, 2024 | 81.25% |
| Sep 30, 2024 | 81.80% |
| Jun 30, 2024 | 83.31% |
| Mar 31, 2024 | 80.96% |
| Dec 31, 2023 | 81.21% |
| Sep 30, 2023 | 81.59% |
| Jun 30, 2023 | 77.94% |
| Mar 31, 2023 | 75.78% |
| Dec 31, 2022 | 75.17% |
| Sep 30, 2022 | 76.06% |
| Jun 30, 2022 | 77.94% |
| Mar 31, 2022 | 77.86% |
| Dec 31, 2021 | 81.64% |
| Sep 30, 2021 | 80.83% |
| Jun 30, 2021 | 83.76% |