Castle Biosciences (CSTL) Gross Margin (2018 - 2026)
Castle Biosciences (CSTL) posted Gross Margin of 75.46% for Q1 2026, down 4.42% sequentially from 78.95% in Q4 2025, and down 592.0% YoY from 15.34% in Q1 2025.
Castle Biosciences (CSTL) Gross Margin (2018 - 2026) Analysis & Trends
Castle Biosciences (CSTL) has 9 years of Gross Margin data on file, last reported at 75.46% in Q1 2026.
- Quarterly Gross Margin fell 592.0% year-over-year to 75.46% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 77.88% (down 405.0% YoY) and the FY2025 annual result came in at 79.37%, down 250.0% from the prior year.
- Gross Margin declined to 75.46% in Q1 2026 per CSTL's latest filing, from 78.95% in the prior quarter.
- The five-year high for Gross Margin was 83.31% in Q2 2024, with the low at 75.17% in Q4 2022.
- Average Gross Margin over 5 years is 79.04%, with a median of 78.95% recorded in 2025.
- Year-over-year, Gross Margin tumbled 886 bps in 2022 and jumped 604 bps in 2023.
- Castle Biosciences' Gross Margin stood at 75.17% in 2022, then gained by 8 bps to 81.21% in 2023, then advanced by 0 bps to 81.25% in 2024, then fell by 3 bps to 78.95% in 2025, then dropped by 4 bps to 75.46% in 2026.
- Business Quant data shows CSTL's Gross Margin at 75.46% in Q1 2026, 78.95% in Q4 2025, and 77.48% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 31,055.11 Bn | 31,054.65 Bn | 1.11 Bn | 87.77% |
| 2 | Thermo Fisher Scientific | 191.02 Bn | 187.77 Bn | 7.74 Bn | 70.37% |
| 3 | Danaher | 137.16 Bn | 131.47 Bn | 3.59 Bn | 60.34% |
| 4 | Idexx Laboratories | 42.82 Bn | 42.62 Bn | 722.74 Mn | 63.35% |
| 5 | Natera | 39.09 Bn | 37.99 Bn | 696.04 Mn | 99.91% |
| 6 | Agilent Technologies | 37.61 Bn | 35.81 Bn | 990.00 Mn | 53.95% |
| 7 | Iqvia Holdings | 34.23 Bn | 32.25 Bn | 1.36 Bn | 32.64% |
| 8 | Illumina | 28.14 Bn | 26.98 Bn | 721.00 Mn | 66.09% |
| 9 | Mettler Toledo International | 26.40 Bn | 26.33 Bn | 555.82 Mn | 58.68% |
| 10 | Castle Biosciences | 738.56 Mn | 476.84 Mn | 63.15 Mn | 75.46% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 75.46% |
| Dec 31, 2025 | 78.95% |
| Sep 30, 2025 | 77.48% |
| Jun 30, 2025 | 79.55% |
| Mar 31, 2025 | 81.38% |
| Dec 31, 2024 | 81.25% |
| Sep 30, 2024 | 81.80% |
| Jun 30, 2024 | 83.31% |
| Mar 31, 2024 | 80.96% |
| Dec 31, 2023 | 81.21% |
| Sep 30, 2023 | 81.59% |
| Jun 30, 2023 | 77.94% |
| Mar 31, 2023 | 75.78% |
| Dec 31, 2022 | 75.17% |
| Sep 30, 2022 | 76.06% |
| Jun 30, 2022 | 77.94% |
| Mar 31, 2022 | 77.86% |
| Dec 31, 2021 | 81.64% |
| Sep 30, 2021 | 80.83% |
| Jun 30, 2021 | 83.76% |