Growth Metrics

Castle Biosciences (CSTL) Gross Margin (2018 - 2026)

Castle Biosciences' Gross Margin history spans 8 years, with the latest figure at 78.95% for Q4 2025.

  • On a quarterly basis, Gross Margin fell 230.0% to 78.95% in Q4 2025 year-over-year; TTM through Dec 2025 was 79.37%, a 250.0% decrease, with the full-year FY2025 number at 79.37%, down 250.0% from a year prior.
  • Gross Margin hit 78.95% in Q4 2025 for Castle Biosciences, up from 77.48% in the prior quarter.
  • Over the last five years, Gross Margin for CSTL hit a ceiling of 86.73% in Q1 2021 and a floor of 75.17% in Q4 2022.
  • Historically, Gross Margin has averaged 80.06% across 5 years, with a median of 80.9% in 2021.
  • Biggest five-year swings in Gross Margin: plummeted -886bps in 2022 and later surged 604bps in 2023.
  • Tracing CSTL's Gross Margin over 5 years: stood at 81.64% in 2021, then decreased by -8bps to 75.17% in 2022, then increased by 8bps to 81.21% in 2023, then rose by 0bps to 81.25% in 2024, then dropped by -3bps to 78.95% in 2025.
  • Business Quant data shows Gross Margin for CSTL at 78.95% in Q4 2025, 77.48% in Q3 2025, and 79.55% in Q2 2025.