Castle Biosciences (CSTL) Gross Margin (2018 - 2026)

Castle Biosciences' (CSTL) quarterly Gross Margin came in at 75.46% in Q1 2026, down 592.0% year-on-year from 15.34% in Q1 2025, and down 4.42% quarter-over-quarter from 78.95% in Q4 2025.

Castle Biosciences (CSTL) Gross Margin (2018 - 2026) Analysis & Trends

Castle Biosciences has disclosed Gross Margin across 9 years of filings, most recently posting 75.46% for Q1 2026.

  • Gross Margin for Q1 2026 came in at 75.46%, down 592.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 77.88% (down 405.0% YoY), and the FY2025 annual result was 79.37%, down 250.0% from the prior year.
  • Gross Margin came in at 75.46% for Q1 2026 at Castle Biosciences, down from 78.95% in the prior quarter.
  • In the past five years, Gross Margin ranged from a high of 83.31% in Q2 2024 to a low of 75.17% in Q4 2022.
  • The 5-year median for Gross Margin is 78.95% (2025), against an average of 79.04%.
  • Across the five-year window, Gross Margin sank 886 bps in 2022 and soared 604 bps in 2023, its largest moves.
  • Castle Biosciences' Gross Margin stood at 75.17% in 2022, then grew by 8 bps to 81.21% in 2023, then increased by 0 bps to 81.25% in 2024, then slipped by 3 bps to 78.95% in 2025, then retreated by 4 bps to 75.46% in 2026.
  • The last three Gross Margin figures came in at 75.46% (Q1 2026), 78.95% (Q4 2025), and 77.48% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Gross Margin (Qtr)
1 Waters 30,529.42 Bn 30,528.96 Bn 1.11 Bn 87.77%
2 Thermo Fisher Scientific 183.75 Bn 180.50 Bn 7.74 Bn 70.37%
3 Danaher 133.13 Bn 127.43 Bn 3.59 Bn 60.34%
4 Idexx Laboratories 46.14 Bn 45.94 Bn 722.74 Mn 63.35%
5 Agilent Technologies 38.20 Bn 36.39 Bn 990.00 Mn 53.95%
6 Natera 31.50 Bn 30.40 Bn 696.04 Mn 99.91%
7 Iqvia Holdings 31.34 Bn 29.36 Bn 1.36 Bn 32.64%
8 Illumina 24.51 Bn 23.36 Bn 721.00 Mn 66.09%
9 Mettler Toledo International 23.53 Bn 23.47 Bn 555.82 Mn 58.68%
10 Castle Biosciences 629.76 Mn 368.04 Mn 63.15 Mn 75.46%

Historic Data

Download Data
DateValue
Mar 31, 2026 75.46%
Dec 31, 2025 78.95%
Sep 30, 2025 77.48%
Jun 30, 2025 79.55%
Mar 31, 2025 81.38%
Dec 31, 2024 81.25%
Sep 30, 2024 81.80%
Jun 30, 2024 83.31%
Mar 31, 2024 80.96%
Dec 31, 2023 81.21%
Sep 30, 2023 81.59%
Jun 30, 2023 77.94%
Mar 31, 2023 75.78%
Dec 31, 2022 75.17%
Sep 30, 2022 76.06%
Jun 30, 2022 77.94%
Mar 31, 2022 77.86%
Dec 31, 2021 81.64%
Sep 30, 2021 80.83%
Jun 30, 2021 83.76%