Castle Biosciences (CSTL) Gross Margin (2018 - 2026)
Castle Biosciences' (CSTL) quarterly Gross Margin came in at 77.11% in Q2 2026, down 244.0% year-over-year from 53.55% in Q2 2025, and up 2.19% quarter-over-quarter from 75.46% in Q1 2026.
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Castle Biosciences (CSTL) Gross Margin (2018 - 2026) Analysis & Trends
Castle Biosciences has disclosed Gross Margin across 9 years of filings, most recently posting 77.11% for Q2 2026.
- In Q2 2026, Gross Margin fell 244.0% year-over-year to 77.11%; the TTM figure through Jun 2026 stood at 77.26% (down 374.0% YoY), while the FY2025 annual figure was 79.37%, down 250.0% from the prior year.
- Gross Margin came in at 77.11% for Q2 2026 at Castle Biosciences, up from 75.46% in the prior quarter.
- In the past five years, Gross Margin ranged from a high of 83.31% in Q2 2024 to a low of 75.17% in Q4 2022.
- Average Gross Margin over 5 years is 78.93%, with a median of 78.45% recorded in 2023.
- Year-over-year, Gross Margin plunged 886 bps in 2022 and jumped 604 bps in 2023.
- Over 5 years, Gross Margin stood at 75.17% in 2022, then grew by 8 bps to 81.21% in 2023, then increased by 0 bps to 81.25% in 2024, then slipped by 3 bps to 78.95% in 2025, then fell by 2 bps to 77.11% in 2026.
- Per Business Quant data, the three most recent Gross Margin figures were 77.11% in Q2 2026, 75.46% in Q1 2026, and 78.95% in Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Natera | 53.05 Bn | 51.95 Bn | 486.15 Mn | 64.58% |
| 2 | Quest Diagnostics | 27.19 Bn | 26.87 Bn | 1.03 Bn | 33.75% |
| 3 | Labcorp Holdings | 25.93 Bn | 25.81 Bn | 1.11 Bn | 29.80% |
| 4 | Guardant Health | 23.97 Bn | 22.91 Bn | 219.03 Mn | 65.39% |
| 5 | Tempus AI | 13.64 Bn | 12.82 Bn | 274.25 Mn | 71.70% |
| 6 | Caris Life Sciences | 8.47 Bn | 7.68 Bn | 182.38 Mn | 69.16% |
| 7 | Sotera Health | 5.35 Bn | 4.99 Bn | 177.96 Mn | 55.38% |
| 8 | BillionToOne | 4.96 Bn | 4.41 Bn | 77.11 Mn | 70.45% |
| 9 | Adaptive Biotechnologies | 4.55 Bn | 4.21 Bn | 51.39 Mn | 71.82% |
| 10 | Castle Biosciences | 1.08 Bn | 811.36 Mn | 79.85 Mn | 77.11% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 77.11% |
| Mar 31, 2026 | 75.46% |
| Dec 31, 2025 | 78.95% |
| Sep 30, 2025 | 77.48% |
| Jun 30, 2025 | 79.55% |
| Mar 31, 2025 | 81.38% |
| Dec 31, 2024 | 81.25% |
| Sep 30, 2024 | 81.80% |
| Jun 30, 2024 | 83.31% |
| Mar 31, 2024 | 80.96% |
| Dec 31, 2023 | 81.21% |
| Sep 30, 2023 | 81.59% |
| Jun 30, 2023 | 77.94% |
| Mar 31, 2023 | 75.78% |
| Dec 31, 2022 | 75.17% |
| Sep 30, 2022 | 76.06% |
| Jun 30, 2022 | 77.94% |
| Mar 31, 2022 | 77.86% |
| Dec 31, 2021 | 81.64% |
| Sep 30, 2021 | 80.83% |
API Access
Castle Biosciences Gross Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=gross-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "gross-margin", "ticker": "CSTL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=gross-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();