Castle Biosciences (CSTL) Net Margin (2018 - 2026)
Castle Biosciences' (CSTL) quarterly Net Margin came in at 1.99% in Q2 2026, down 728.0% year-over-year from 0.32% in Q2 2025, and up 88.54% quarter-over-quarter from 17.35% in Q1 2026.
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Castle Biosciences (CSTL) Net Margin (2018 - 2026) Analysis & Trends
Castle Biosciences has disclosed Net Margin across 9 years of filings, most recently posting 1.99% for Q2 2026.
- In Q2 2026, Net Margin fell 728.0% year-over-year to 1.99%; the TTM figure through Jun 2026 stood at 5.43% (down 271.0% YoY), while the FY2025 annual figure was 7.02%, down 1251.0% from the prior year.
- Net Margin came in at 1.99% for Q2 2026 at Castle Biosciences, up from 17.35% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 11.11% in Q4 2024 to a low of 91.7% in Q1 2022.
- Average Net Margin over 5 years is 19.62%, with a median of 4.32% recorded in 2022.
- Year-over-year, Net Margin plunged 7294 bps in 2022 and surged 6600 bps in 2024.
- Over 5 years, Net Margin stood at 53.78% in 2022, then jumped by 93 bps to 3.9% in 2023, then jumped by 385 bps to 11.11% in 2024, then sank by 124 bps to 2.68% in 2025, then increased by 26 bps to 1.99% in 2026.
- Per Business Quant data, the three most recent Net Margin figures were 1.99% in Q2 2026, 17.35% in Q1 2026, and 2.68% in Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Natera | 53.05 Bn | 51.95 Bn | 486.15 Mn | -8.89% |
| 2 | Quest Diagnostics | 27.19 Bn | 26.87 Bn | 1.03 Bn | 10.65% |
| 3 | Labcorp Holdings | 25.93 Bn | 25.81 Bn | 1.11 Bn | 8.02% |
| 4 | Guardant Health | 23.97 Bn | 22.91 Bn | 219.03 Mn | -35.87% |
| 5 | Tempus AI | 13.64 Bn | 12.82 Bn | 274.25 Mn | 2.22% |
| 6 | Caris Life Sciences | 8.47 Bn | 7.68 Bn | 182.38 Mn | -0.24% |
| 7 | Sotera Health | 5.35 Bn | 4.99 Bn | 177.96 Mn | 16.69% |
| 8 | BillionToOne | 4.96 Bn | 4.41 Bn | 77.11 Mn | 7.36% |
| 9 | Adaptive Biotechnologies | 4.55 Bn | 4.21 Bn | 51.39 Mn | -22.65% |
| 10 | Castle Biosciences | 1.08 Bn | 811.36 Mn | 79.85 Mn | -1.99% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -1.99% |
| Mar 31, 2026 | -17.35% |
| Dec 31, 2025 | -2.68% |
| Sep 30, 2025 | -0.60% |
| Jun 30, 2025 | 5.29% |
| Mar 31, 2025 | -29.38% |
| Dec 31, 2024 | 11.11% |
| Sep 30, 2024 | 2.65% |
| Jun 30, 2024 | 10.25% |
| Mar 31, 2024 | -3.47% |
| Dec 31, 2023 | -3.90% |
| Sep 30, 2023 | -11.23% |
| Jun 30, 2023 | -37.45% |
| Mar 31, 2023 | -69.47% |
| Dec 31, 2022 | -53.78% |
| Sep 30, 2022 | -54.71% |
| Jun 30, 2022 | -4.73% |
| Mar 31, 2022 | -91.70% |
| Dec 31, 2021 | -25.68% |
| Sep 30, 2021 | -50.23% |
API Access
Castle Biosciences Net Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=net-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "net-margin", "ticker": "CSTL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=net-margin&ticker=CSTL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();