Castle Biosciences (CSTL) Operating Income (2018 - 2026)

Castle Biosciences' (CSTL) quarterly Operating Income came in at -$18.4 million in Q1 2026, up 34.09% year-on-year from -$13.7 million in Q1 2025, and down 380.98% quarter-over-quarter from -$3.8 million in Q4 2025.

Castle Biosciences (CSTL) Operating Income (2018 - 2026) Analysis & Trends

Castle Biosciences has disclosed Operating Income across 9 years of filings, most recently posting -$18.4 million for Q1 2026.

  • Operating Income for Q1 2026 came in at -$18.4 million, up 34.09% year-over-year; the trailing twelve-month figure through Mar 2026 was -$33.3 million (down 141.45% YoY), and the FY2025 annual result was -$42.8 million, down 593.77% from the prior year.
  • Operating Income came in at -$18.4 million for Q1 2026 at Castle Biosciences, down from -$3.8 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of $5.1 million in Q3 2024 to a low of -$31.5 million in Q1 2023.
  • The 5-year median for Operating Income is -$6.8 million (2025), against an average of -$11.4 million.
  • Across the five-year window, Operating Income slumped 472.27% in 2022 and soared 171.58% in 2024, its largest moves.
  • Castle Biosciences' Operating Income stood at -$22.8 million in 2022, then surged by 75.22% to -$5.7 million in 2023, then surged by 171.58% to $4.0 million in 2024, then plunged by 194.49% to -$3.8 million in 2025, then plunged by 380.98% to -$18.4 million in 2026.
  • The last three Operating Income figures came in at -$18.4 million (Q1 2026), -$3.8 million (Q4 2025), and -$6.8 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Waters 29,902.70 Bn 29,902.24 Bn 1.11 Bn -47.00 Mn
2 Thermo Fisher Scientific 175.99 Bn 172.74 Bn 7.74 Bn 1.86 Bn
3 Danaher 129.87 Bn 124.18 Bn 3.59 Bn 1.34 Bn
4 Idexx Laboratories 44.75 Bn 44.55 Bn 722.74 Mn 362.59 Mn
5 Agilent Technologies 37.52 Bn 35.72 Bn 990.00 Mn 399.00 Mn
6 Iqvia Holdings 30.91 Bn 28.94 Bn 1.36 Bn 514.00 Mn
7 Natera 30.21 Bn 29.11 Bn 696.04 Mn -93.52 Mn
8 Illumina 24.19 Bn 23.04 Bn 721.00 Mn 209.00 Mn
9 Mettler Toledo International 23.12 Bn 23.06 Bn 555.82 Mn 238.95 Mn
10 Castle Biosciences 601.82 Mn 340.09 Mn 63.15 Mn -18.41 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -18.41 Mn
Dec 31, 2025 -3.83 Mn
Sep 30, 2025 -6.80 Mn
Jun 30, 2025 -4.25 Mn
Mar 31, 2025 -27.93 Mn
Dec 31, 2024 4.05 Mn
Sep 30, 2024 5.08 Mn
Jun 30, 2024 5.01 Mn
Mar 31, 2024 -5.47 Mn
Dec 31, 2023 -5.66 Mn
Sep 30, 2023 -9.64 Mn
Jun 30, 2023 -21.16 Mn
Mar 31, 2023 -31.52 Mn
Dec 31, 2022 -22.83 Mn
Sep 30, 2022 -21.54 Mn
Jun 30, 2022 -3.97 Mn
Mar 31, 2022 -24.52 Mn
Dec 31, 2021 -15.17 Mn
Sep 30, 2021 -11.81 Mn
Jun 30, 2021 -8.81 Mn