Twist Bioscience (TWST) Operating Margin (2017 - 2026)
Twist Bioscience (TWST) reported Operating Margin of 41.42% for Q1 2026, up 336.0% year-over-year from 9.5% in Q1 2025, and down 30.57% quarter-over-quarter from 31.73% in Q4 2025.
Twist Bioscience (TWST) Operating Margin (2017 - 2026) Analysis & Trends
Twist Bioscience (TWST) has 10 years of Operating Margin data on file, last reported at 41.42% in Q1 2026.
- Operating Margin for Q1 2026 came in at 41.42%, up 336.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 33.9% (up 2396.0% YoY), and the FY2025 annual result was 36.18%, up 3437.0% from the prior year.
- Operating Margin fell to 41.42% in Q1 2026 per TWST's latest filing, from 31.73% in the prior quarter.
- Over five years, Operating Margin peaked at 30.23% in Q3 2025 and troughed at 126.34% in Q1 2022.
- A 5-year average of 70.02% and a median of 65.7% in 2023 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2024 and 2025: Operating Margin slumped 1380 bps in 2024, then soared 7780 bps in 2025.
- A 5-year view of Operating Margin shows it stood at 82.28% in 2022, then climbed by 20 bps to 65.7% in 2023, then surged by 41 bps to 39.05% in 2024, then rose by 19 bps to 31.73% in 2025, then slumped by 31 bps to 41.42% in 2026.
- Business Quant data shows TWST's Operating Margin at 41.42% in Q1 2026, 31.73% in Q4 2025, and 30.23% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Waters | 30,529.42 Bn | 30,528.96 Bn | 1.11 Bn | -3.71% |
| 2 | Thermo Fisher Scientific | 183.75 Bn | 180.50 Bn | 7.74 Bn | 16.93% |
| 3 | Danaher | 133.13 Bn | 127.43 Bn | 3.59 Bn | 22.58% |
| 4 | Idexx Laboratories | 46.14 Bn | 45.94 Bn | 722.74 Mn | 31.78% |
| 5 | Agilent Technologies | 38.20 Bn | 36.39 Bn | 990.00 Mn | 21.74% |
| 6 | Natera | 31.50 Bn | 30.40 Bn | 696.04 Mn | -13.42% |
| 7 | Iqvia Holdings | 31.34 Bn | 29.36 Bn | 1.36 Bn | 12.38% |
| 8 | Illumina | 24.51 Bn | 23.36 Bn | 721.00 Mn | 19.16% |
| 9 | Mettler Toledo International | 23.53 Bn | 23.47 Bn | 555.82 Mn | 25.23% |
| 10 | Twist Bioscience | 4.30 Bn | 4.30 Bn | 57.12 Mn | -41.42% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -41.42% |
| Dec 31, 2025 | -31.73% |
| Sep 30, 2025 | -30.23% |
| Jun 30, 2025 | -31.36% |
| Mar 31, 2025 | -44.79% |
| Dec 31, 2024 | -39.05% |
| Sep 30, 2024 | -42.55% |
| Jun 30, 2024 | -109.15% |
| Mar 31, 2024 | -64.92% |
| Dec 31, 2023 | -65.70% |
| Sep 30, 2023 | -74.85% |
| Jun 30, 2023 | -95.36% |
| Mar 31, 2023 | -102.42% |
| Dec 31, 2022 | -82.28% |
| Sep 30, 2022 | -99.24% |
| Jun 30, 2022 | -109.00% |
| Mar 31, 2022 | -126.34% |
| Dec 31, 2021 | -133.13% |
| Sep 30, 2021 | -104.90% |
| Jun 30, 2021 | -120.28% |