Twist Bioscience (TWST) Operating Margin (2017 - 2026)
Twist Bioscience (TWST) posted Operating Margin of -30.65% for fiscal Q3 2026 (quarter ended Jun 30, 2026), up 0.71 percentage points from -31.36% a year earlier and up 10.78 percentage points from the prior quarter.
Twist Bioscience (TWST) Operating Margin (2017 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Twist Bioscience was -33.58%, up 5.72 percentage points year-over-year; for FY2025 (ended Sep 30, 2025), it came in at -36.18%, up 34.37 percentage points from FY2024.
- Annual Operating Margin has increased for eight consecutive fiscal years, with a five-year change of +119.29 percentage points (FY2020 to FY2025).
- In prior fiscal years, Twist Bioscience's Operating Margin was -70.56% in FY2024 (+18.04 pp), -88.60% in FY2023 (+26.74 pp), -115.33% in FY2022 (+0.08 pp) and -115.41% in FY2021 (+40.06 pp).
- Quarterly Operating Margin has run from a low of -133.13% in fiscal Q1 2022 to a high of -30.23% in fiscal Q4 2025 over five years.
- On a year-over-year basis, Operating Margin has increased in each of the last eight quarters, with an average year-over-year change of +22.58 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Operating Margin in the past five years was fiscal Q3 2025, with a gain of 77.80 percentage points; the weakest was fiscal Q4 2021, with a drop of 31.00 percentage points.
- According to Business Quant data, Operating Margin for the three prior fiscal quarters was -41.42% (Q2 2026), -31.73% (Q1 2026) and -30.23% (Q4 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Thermo Fisher Scientific | 243.20 Bn | 222.35 Bn | 4.88 Bn | 17.40% |
| 2 | Abbott Laboratories | 172.35 Bn | 143.43 Bn | 7.27 Bn | 13.44% |
| 3 | Danaher | 154.53 Bn | 138.35 Bn | 3.61 Bn | 17.99% |
| 4 | Intuitive Surgical | 150.04 Bn | 129.59 Bn | 1.96 Bn | 33.60% |
| 5 | Medtronic | 113.25 Bn | 79.11 Bn | 6.34 Bn | 18.08% |
| 6 | Stryker | 106.37 Bn | 92.49 Bn | 4.50 Bn | 25.18% |
| 7 | Boston Scientific | 61.94 Bn | 56.95 Bn | 3.85 Bn | 21.65% |
| 8 | Becton Dickinson | 50.05 Bn | 47.20 Bn | 2.32 Bn | 13.31% |
| 9 | Edwards Lifesciences | 49.13 Bn | 33.24 Bn | 1.35 Bn | 29.48% |
| 10 | Twist Bioscience | 10.01 Bn | 9.25 Bn | 62.45 Mn | -30.65% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -30.65% |
| Mar 31, 2026 | -41.42% |
| Dec 31, 2025 | -31.73% |
| Sep 30, 2025 | -30.23% |
| Jun 30, 2025 | -31.36% |
| Mar 31, 2025 | -44.79% |
| Dec 31, 2024 | -39.05% |
| Sep 30, 2024 | -42.55% |
| Jun 30, 2024 | -109.15% |
| Mar 31, 2024 | -64.92% |
| Dec 31, 2023 | -65.70% |
| Sep 30, 2023 | -74.85% |
| Jun 30, 2023 | -95.36% |
| Mar 31, 2023 | -102.42% |
| Dec 31, 2022 | -82.28% |
| Sep 30, 2022 | -99.24% |
| Jun 30, 2022 | -109.00% |
| Mar 31, 2022 | -126.34% |
| Dec 31, 2021 | -133.13% |
| Sep 30, 2021 | -104.90% |
Twist Bioscience Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=TWST&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "TWST", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=TWST&period=max&api_key=YOUR_API_KEY");
const data = await res.json();