Septerna SEPN Institutional Ownership

NASDAQ SEPN

$40.76 +1.41 (+3.58%)

At close: Oct 21, 2026 · 4:00 PM EDT

Institutions by Trading Activity

154 Institutions

Increased 97 63.0%

Unchanged 25 16.2%

Reduced 32 20.8%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

—

13F totals exceed reported shares outstanding

Shares Held by Institutions

47.24Mn

of 45.67Mn outstanding

▲+3.33% QoQ

Shares Outstanding

45.67Mn

Institutional Investors

154

filed 13F for Jun 2026

▲+30 vs prior quarter

Net Shares Added (QoQ)

+1.52Mn

accumulated since last quarter

Value of Holdings

$1.86Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Septerna, Inc. (NASDAQ:SEPN) was held by 154 institutional investors that filed 13F reports for the quarter ended June 30, 2026.

Total shares held in Septerna rose 3.33% from Q1 2026, while the number of holders rose 79.07% from Q2 2025.
Of these 154 holders, 97 added to their positions, 32 reduced their stakes and 25 left their positions unchanged.
Combined, institutional investors held 47.24Mn shares of SEPN as of Q2 2026, up 1.52Mn from the prior quarter and up 2.92Mn from a year earlier.
Ra Capital Management, L.P. led 13F holders of SEPN with 7Mn shares as of June 30, 2026.
Holders that added the most shares of Septerna in Q2 2026 were Algert Global LLC (+376.45K shares), Catalio Capital Management, LP (+241.79K shares), First Light Asset Management, LLC (+230.4K shares), Longaeva Partners L.P. (+223.6K shares) and Goldman Sachs Group Inc (+156.34K shares).
The biggest cuts to SEPN positions during Q2 2026 came from ADAR1 Capital Management, LLC (-149.07K shares), Siren, L.L.C. (-100K shares), Millennium Management LLC (-73.54K shares), Invesco Ltd. (-58.77K shares) and Hussman Strategic Advisors, Inc. (-42K shares).
Per Business Quant, the top 10 investors in SEPN for the quarter ended June 30, 2026 were Ra Capital Management, L.P. (7Mn shares), TRV GP V, LLC (6.22Mn shares), Driehaus Capital Management LLC (4.43Mn shares), TRV GP VI, LLC (4.21Mn shares), Samsara BioCapital, LLC (3.15Mn shares), Goldman Sachs Group Inc (3.06Mn shares), BlackRock, Inc. (1.93Mn shares), Siren, L.L.C. (1.9Mn shares), Avoro Capital Advisors LLC (1.34Mn shares) and Jupiter Topco LLC (1.31Mn shares).

Form 13F Holdings

154 Institutional Holders

Report period 30 Jun, 2026

Total shares held 47.24Mn

Of outstanding —

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	RA CAPITAL MANAGEMENT, L.P.	0001346824	6,995,858	15.32%	0	0.00%	$234.29Mn
2	TRV GP V, LLC	0001990717	6,215,591	13.61%	0	0.00%	$208.16Mn
3	DRIEHAUS CAPITAL MANAGEMENT LLC	0000938206	4,433,058	9.71%	▲37,486	+0.85%	$148.46Mn
4	TRV GP VI, LLC	0001990716	4,211,659	9.22%	0	0.00%	$141.05Mn
5	Samsara BioCapital, LLC	0001744967	3,149,128	6.90%	0	0.00%	$105.46Mn
6	Goldman Sachs Group Inc	0000886982	3,062,766	6.71%	▲156,339	+5.38%	$102.57Mn
7	BlackRock, Inc.	0002012383	1,932,088	4.23%	▲109,914	+6.03%	$64.71Mn
8	Siren, L.L.C.	0002005245	1,900,000	4.16%	▼100,000	-5.00%	$63.63Mn
9	Avoro Capital Advisors LLC	0001633313	1,337,500	2.93%	0	0.00%	$44.79Mn
10	Jupiter Topco LLC	0002146052	1,307,500	2.86%	▲1,307,500	0.00%	$43.72Mn
11	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	1,221,673	2.68%	▲24,711	+2.06%	$40.91Mn
12	PRIMECAP MANAGEMENT CO/CA/	0000763212	1,167,382	2.56%	▲118,548	+11.30%	$39.10Mn
13	First Light Asset Management, LLC	0001600004	963,260	2.11%	▲230,400	+31.44%	$32.26Mn
14	ADAR1 Capital Management, LLC	0001940272	940,747	2.06%	▼149,071	-13.68%	$31.51Mn
15	GEODE CAPITAL MANAGEMENT, LLC	0001214717	679,163	1.49%	▲34,017	+5.27%	$22.75Mn
16	State Street Corp	0000093751	652,630	1.43%	▲21,183	+3.35%	$21.86Mn
17	LOOMIS SAYLES & CO L P	0000312348	624,752	1.37%	▲624,752	0.00%	$20.92Mn
18	Casdin Capital, LLC	0001534261	553,268	1.21%	0	0.00%	$18.53Mn
19	Catalio Capital Management, LP	0001958125	536,152	1.17%	▲241,792	+82.14%	$17.96Mn
20	ALGERT GLOBAL LLC	0001275218	397,487	0.87%	▲376,452	+1,789.65%	$13.31Mn

Showing 1 to 20 of 154 holders