Taysha Gene Therapies (TSHA) Operating Margin (2023 - 2025)

Taysha Gene Therapies' (TSHA) quarterly Operating Margin came in at 2334.98% in Q4 2025, down 134923.0% year-on-year from N/an in Q4 2024, and down 73.34% quarter-over-quarter from 1347.08% in Q2 2025.

Taysha Gene Therapies (TSHA) Operating Margin (2023 - 2025) Analysis & Trends

Taysha Gene Therapies has disclosed Operating Margin across 3 years of filings, most recently posting 2334.98% for Q4 2025.

  • Operating Margin for Q4 2025 came in at 2334.98%, down 134923.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 4145.18% (down 291941.0% YoY), and the FY2025 annual result was 2009.05%, down 91150.0% from the prior year.
  • Operating Margin came in at 2334.98% for Q4 2025 at Taysha Gene Therapies, down from 1347.08% in the prior quarter.
  • In the past five years, Operating Margin ranged from a high of 342.39% in Q3 2023 to a low of 2334.98% in Q4 2025.
  • The 3-year median for Operating Margin is 976.37% (2023), against an average of 1072.44%.
  • Peak annual rise in Operating Margin reached 56830 bps in 2025, while the deepest fall reached 134923 bps in 2025.
  • Taysha Gene Therapies' Operating Margin stood at 450.78% in 2023, then sank by 119 bps to 985.76% in 2024, then tumbled by 137 bps to 2334.98% in 2025.
  • The last three Operating Margin figures came in at 2334.98% (Q4 2025), 1347.08% (Q2 2025), and 930.54% (Q1 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Operating Margin (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -6.43%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 38.10%
9 Abivax 91.96 Bn 91.96 Bn - -
10 Taysha Gene Therapies 2.36 Bn 2.36 Bn - -

Historic Data

Download Data
DateValue
Dec 31, 2025 -2,334.98%
Jun 30, 2025 -1,347.08%
Mar 31, 2025 -930.54%
Dec 31, 2024 -985.76%
Sep 30, 2024 -1,448.43%
Jun 30, 2024 -1,915.38%
Mar 31, 2024 -713.28%
Dec 31, 2023 -450.78%
Sep 30, 2023 -342.39%
Jun 30, 2023 -976.37%
Mar 31, 2023 -351.87%