Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

363,700,000Shares Outstanding

53,204,881Shares held by institutions

$243,678,355Value of institutional holdings

73.49%Institutional ownership %

5.12%Shares Changed QoQ

186No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Taysha Gene Therapies, Inc. (NASDAQ:TSHA) is held by 186 institutional firms.

The collective stake of institutional investors in Taysha Gene Therapies moved to 73.5% in December 2025, a shift up from the 72.9% reported for September 2025.
Quarterly data indicates a 5.12% shift in institutional share volume, and the annual owner count reflects an increase of 44.19%.
A review of institutional activity for Taysha Gene Therapies shows 118 of 186 filers increasing their positions, while 46 reduced their stake, and 22 remained unchanged.
The aggregate institutional position in Taysha Gene Therapies now stands at 267.30Mn shares as of December 2025, after investors increased their holdings (up by 13.03Mn shares quarter on quarter which is up 99.92Mn shares year over year).
As of December 31, 2025, RA CAPITAL MANAGEMENT, L.P. held Taysha Gene Therapies's largest shareholding position with over 23.56Mn shares, representing 6.48% of total outstanding shares.
Among the most significant buyers of Taysha Gene Therapies during December 2025 were Vestal Point Capital, LP (8.25Mn), HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND (3.72Mn), STATE STREET CORP (3.55Mn), Polar Capital Holdings Plc (2.64Mn), BlackRock, Inc. (2.28Mn).
Leading sellers of Taysha Gene Therapies stock in December 2025 included RTW INVESTMENTS, LP (7.96Mn), Point72 Asset Management, L.P. (3.46Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (2.66Mn), Jefferies Financial Group Inc. (2.13Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (2.00Mn).
The top 10 institutional holders of Taysha Gene Therapies for the quarter ending December 2025 included RA CAPITAL MANAGEMENT, L.P. (23.56Mn), Avoro Capital Advisors LLC (21.70Mn), BlackRock, Inc. (18.64Mn), MORGAN STANLEY (18.08Mn), RTW INVESTMENTS, LP (16.40Mn), Vestal Point Capital, LP (13.75Mn), GOLDMAN SACHS GROUP INC (13.69Mn), FMR LLC (13.53Mn), VANGUARD GROUP INC (13.27Mn), STATE STREET CORP (10.79Mn).

186 Institutional Holders

53,204,881 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	23,555,648	0	0.00%	$129,556,064.00
Avoro Capital Advisors LLC	31 Dec, 2025	21,700,000	0	0.00%	$119,350,000.00
BlackRock, Inc.	31 Dec, 2025	18,643,129	2,278,268	13.92%	$102,537,212.00
MORGAN STANLEY	31 Dec, 2025	18,078,518	-1,229,085	-6.37%	$99,431,850.00
RTW INVESTMENTS, LP	31 Dec, 2025	16,398,297	-7,955,994	-32.67%	$90,190,634.00
Vestal Point Capital, LP	31 Dec, 2025	13,750,000	8,250,000	150.00%	$75,625,000.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	13,692,739	309,031	2.31%	$75,310,065.00
FMR LLC	31 Dec, 2025	13,528,366	-1,065,046	-7.30%	$74,406,012.00
VANGUARD GROUP INC	31 Dec, 2025	13,267,805	418,192	3.25%	$72,972,929.00
STATE STREET CORP	31 Dec, 2025	10,790,084	3,553,619	49.11%	$59,345,462.00
Siren, L.L.C.	31 Dec, 2025	10,129,913	-884,824	-8.03%	$55,714,522.00
Octagon Capital Advisors LP	31 Dec, 2025	8,859,911	-207,589	-2.29%	$48,729,511.00
Polar Capital Holdings Plc	31 Dec, 2025	7,931,403	2,637,524	49.82%	$43,622,717.00
BARCLAYS PLC	31 Dec, 2025	5,539,001	390,889	7.59%	$30,464,506.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,387,026	212,510	4.11%	$29,633,569.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	4,013,635	1,307,201	48.30%	$22,074,993.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	4,004,756	0	0.00%	$22,026,158.00
Point72 Asset Management, L.P.	31 Dec, 2025	3,868,682	-3,462,788	-47.23%	$21,277,751.00
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	31 Dec, 2025	3,722,000	3,722,000	0.00%	$20,471,000.00
Affinity Asset Advisors, LLC	31 Dec, 2025	3,300,000	300,000	10.00%	$18,150,000.00

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