Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

353,309,524Shares Outstanding

306,726,971Shares held by institutions

$1,956,918,075Value of institutional holdings

86.82%Institutional ownership %

17.52%Shares Changed QoQ

191No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Taysha Gene Therapies, Inc. (NASDAQ:TSHA) showed up in the 13F filings of 190 institutional investors as of December 2025.

Collectively, these holders controlled 76.7% of Taysha Gene Therapies's outstanding shares in December 2025, up from 75.4% in September 2025.
They increased total shares held in TSHA by 6.06% quarter over quarter, and investors in Taysha Gene Therapies increased 46.15% from a year ago.
During the quarter, 123 of these 190 funds increased positions in TSHA, 45 reduced exposure, and 22 held steady.
Institutional investors collectively held 271.1Mn shares in Taysha Gene Therapies as of December 2025, up by 15.49Mn shares quarter on quarter, and up 85.56Mn shares year over year.
SG Americas Securities, LLC is the top holder of Taysha Gene Therapies as of December 31, 2025, with 2.18Mn shares representing 0.62% of outstanding stock.
The most significant purchases of TSHA for the quarter ending December 2025 came from SG Americas Securities, LLC (1.4Mn), E Fund Management Co., Ltd. (37.7K), Capital Investment Advisors, LLC (10.0K), Abacus Wealth Partners, LLC (3.07K), NBC SECURITIES, INC. (1.1K).
Leading sellers of Taysha Gene Therapies shares for the quarter ending December 2025 were Allegheny Financial Group (14.35K), GAMMA Investing LLC (141).
Taysha Gene Therapies's 10 largest shareholders as of December 2025 include SG Americas Securities, LLC (2.18Mn), Abacus Wealth Partners, LLC (58.24K), NBC SECURITIES, INC. (54.06K), Williams & Novak, LLC (45.0K), E Fund Management Co., Ltd. (37.7K), Lee Financial Co (20.0K), Capital Investment Advisors, LLC (20.0K), Pictet Asset Management Holding SA (19.32K), Allegheny Financial Group (12.0K), ST GERMAIN D J CO INC (9.63K) per Business Quant data.

195 Institutional Holders

306,726,971 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	43,400,000	21,700,000	100.00%	$238,700,000.00
Goldman Sachs Group Inc	31 Dec, 2025	27,385,478	14,001,770	104.62%	$150,620,130.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	23,555,648	0	0.00%	$129,556,064.00
BlackRock, Inc.	31 Dec, 2025	18,643,129	2,278,268	13.92%	$102,537,212.00
Morgan Stanley	31 Dec, 2025	18,078,518	-1,229,085	-6.37%	$99,431,850.00
RTW INVESTMENTS, LP	31 Dec, 2025	16,398,297	-7,955,994	-32.67%	$90,190,634.00
Vestal Point Capital, LP	31 Dec, 2025	13,750,000	8,250,000	150.00%	$75,625,000.00
FMR LLC	31 Dec, 2025	13,528,366	-1,065,046	-7.30%	$74,406,012.00
VANGUARD GROUP INC	31 Dec, 2025	13,267,805	418,192	3.25%	$72,972,929.00
State Street Corp	31 Dec, 2025	10,790,084	3,553,619	49.11%	$59,345,462.00
Siren, L.L.C.	31 Dec, 2025	10,129,913	-884,824	-8.03%	$55,714,522.00
Octagon Capital Advisors LP	31 Dec, 2025	8,859,911	-207,589	-2.29%	$48,729,511.00
Polar Capital Holdings Plc	31 Dec, 2025	7,931,403	2,637,524	49.82%	$43,622,717.00
Barclays Plc	31 Dec, 2025	5,539,001	-5,004,503	-47.47%	$30,464,506.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,387,026	212,510	4.11%	$29,633,569.00
ADAR1 Capital Management, LLC	31 Dec, 2025	4,991,618	2,155,938	76.03%	$27,453,900.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	4,013,635	1,307,201	48.30%	$22,074,993.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	4,004,756	0	0.00%	$22,026,158.00
Point72 Asset Management, L.P.	31 Dec, 2025	3,868,682	-3,462,788	-47.23%	$21,277,751.00
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	31 Dec, 2025	3,722,000	3,722,000	0.00%	$20,471,000.00

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