Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

5,781,867Shares held by institutions

$23,561,108Value of institutional holdings

81.16%Institutional ownership %

48.17%Shares Changed QoQ

147No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Taysha Gene Therapies, Inc. (NASDAQ:TSHA) appears in 190 institutional 13F filings for the quarter ending December 2025.

Their combined ownership stood at 76.7% of outstanding shares in December 2025, up from 75.4% in September 2025.
Their total shares held in TSHA increased 6.06% from the prior quarter, while the number of investors in Taysha Gene Therapies increased 46.15% year over year.
During the quarter, 123 of these 190 funds increased positions in TSHA, 45 reduced exposure, and 22 held steady.
Combined, these investors held 271.1Mn shares in TSHA for December 2025, up by 15.49Mn shares quarter on quarter, and up 85.56Mn shares year over year.
As of December 31, 2025, the biggest holder of Taysha Gene Therapies is RA CAPITAL MANAGEMENT, L.P. at 23.56Mn shares, representing 6.67% of shares outstanding.
Top purchasers of TSHA stock for the quarter ending December 2025 included Vestal Point Capital, LP (8.25Mn), HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND (3.72Mn), State Street Corp (3.55Mn), Polar Capital Holdings Plc (2.64Mn), BlackRock, Inc. (2.28Mn).
The biggest sellers of Taysha Gene Therapies for the quarter ending December 2025 included RTW INVESTMENTS, LP (7.96Mn), Point72 Asset Management, L.P. (3.46Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (2.66Mn), Jefferies Financial Group Inc. (2.13Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (2.0Mn).
Business Quant data shows the 10 biggest positions in Taysha Gene Therapies as of December 2025 are held by RA CAPITAL MANAGEMENT, L.P. (23.56Mn), Avoro Capital Advisors LLC (21.7Mn), BlackRock, Inc. (18.64Mn), Morgan Stanley (18.08Mn), RTW INVESTMENTS, LP (16.4Mn), Vestal Point Capital, LP (13.75Mn), Goldman Sachs Group Inc (13.69Mn), FMR LLC (13.53Mn), VANGUARD GROUP INC (13.27Mn), State Street Corp (10.79Mn).

190 Institutional Holders

5,781,867 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	2,278,268	13.92%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	0	0.00%	$0.00
Avoro Capital Advisors LLC	31 Dec, 2025	21,700,000	100.00%	$0.00
Morgan Stanley	31 Dec, 2025	-1,229,085	-6.37%	$0.00
Vestal Point Capital, LP	31 Dec, 2025	8,250,000	150.00%	$0.00
Barclays Plc	31 Dec, 2025	143,609	2.66%	$0.00
RTW INVESTMENTS, LP	31 Dec, 2025	-7,955,994	-32.67%	$0.00
Siren, L.L.C.	31 Dec, 2025	-884,824	-8.03%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	5,000	100.00%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	309,031	2.31%	$0.00
Octagon Capital Advisors LP	31 Dec, 2025	-207,589	-2.29%	$0.00
FMR LLC	31 Dec, 2025	-1,065,046	-7.30%	$0.00
Polar Capital Holdings Plc	31 Dec, 2025	2,637,524	49.82%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	418,192	3.25%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,155,938	76.03%	$0.00
State Street Corp	31 Dec, 2025	3,553,619	49.11%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	-3,462,788	-47.23%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	300,000	10.00%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	212,510	4.11%	$0.00
B Group, Inc.	31 Dec, 2025	0	0.00%	$0.00

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