Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

353,309,524Shares Outstanding

306,661,021Shares held by institutions

$1,821,566,465Value of institutional holdings

86.80%Institutional ownership %

17.49%Shares Changed QoQ

190No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Taysha Gene Therapies, Inc. (NASDAQ:TSHA) is held by 190 institutional investors per 13F filings through December 2025.

They owned 76.7% of outstanding stock in December 2025, up from 75.4% the prior quarter.
They increased total shares held in TSHA by 6.06% quarter over quarter, and investors in Taysha Gene Therapies increased 46.15% from a year ago.
During the quarter, 123 of these 190 funds increased positions in TSHA, 45 reduced exposure, and 22 held steady.
The aggregate institutional position in Taysha Gene Therapies amounted to 271.1Mn shares as of December 2025, up by 15.49Mn shares quarter on quarter, and up 85.56Mn shares year over year.
Avoro Capital Advisors LLC leads ownership in TSHA with 43.4Mn shares as of December 31, 2025, equal to 12.28% of outstanding shares.
The most significant purchases of TSHA for the quarter ending December 2025 came from Avoro Capital Advisors LLC (21.7Mn), Goldman Sachs Group Inc (14.0Mn), Vestal Point Capital, LP (8.25Mn), HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND (3.72Mn), State Street Corp (3.55Mn).
Top sellers of TSHA stock for the quarter ending December 2025 included RTW INVESTMENTS, LP (7.96Mn), Barclays Plc (5.0Mn), Point72 Asset Management, L.P. (3.46Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (2.66Mn), Jefferies Financial Group Inc. (2.13Mn).
Taysha Gene Therapies's 10 largest shareholders as of December 2025 include Avoro Capital Advisors LLC (43.4Mn), Goldman Sachs Group Inc (27.39Mn), RA CAPITAL MANAGEMENT, L.P. (23.56Mn), BlackRock, Inc. (18.64Mn), Morgan Stanley (18.08Mn), RTW INVESTMENTS, LP (16.4Mn), Vestal Point Capital, LP (13.75Mn), FMR LLC (13.53Mn), VANGUARD GROUP INC (13.27Mn), State Street Corp (10.79Mn) per Business Quant data.

190 Institutional Holders

306,661,021 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	43,400,000	21,700,000	100.00%	$238,700,000.00
Goldman Sachs Group Inc	31 Dec, 2025	27,385,478	14,001,770	104.62%	$150,620,130.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	23,555,648	0	0.00%	$129,556,064.00
BlackRock, Inc.	31 Dec, 2025	18,643,129	2,278,268	13.92%	$102,537,212.00
Morgan Stanley	31 Dec, 2025	18,078,518	-1,229,085	-6.37%	$99,431,850.00
RTW INVESTMENTS, LP	31 Dec, 2025	16,398,297	-7,955,994	-32.67%	$90,190,634.00
Vestal Point Capital, LP	31 Dec, 2025	13,750,000	8,250,000	150.00%	$75,625,000.00
FMR LLC	31 Dec, 2025	13,528,366	-1,065,046	-7.30%	$74,406,012.00
VANGUARD GROUP INC	31 Dec, 2025	13,267,805	418,192	3.25%	$72,972,929.00
State Street Corp	31 Dec, 2025	10,790,084	3,553,619	49.11%	$59,345,462.00
Siren, L.L.C.	31 Dec, 2025	10,129,913	-884,824	-8.03%	$55,714,522.00
Octagon Capital Advisors LP	31 Dec, 2025	8,859,911	-207,589	-2.29%	$48,729,511.00
Polar Capital Holdings Plc	31 Dec, 2025	7,931,403	2,637,524	49.82%	$43,622,717.00
Barclays Plc	31 Dec, 2025	5,539,001	-5,004,503	-47.47%	$30,464,506.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,387,026	212,510	4.11%	$29,633,569.00
ADAR1 Capital Management, LLC	31 Dec, 2025	4,991,618	2,155,938	76.03%	$27,453,900.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	4,013,635	1,307,201	48.30%	$22,074,993.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	4,004,756	0	0.00%	$22,026,158.00
Point72 Asset Management, L.P.	31 Dec, 2025	3,868,682	-3,462,788	-47.23%	$21,277,751.00
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	31 Dec, 2025	3,722,000	3,722,000	0.00%	$20,471,000.00

1 - 20 of 190

Research Tools