Spero Therapeutics SPRO Insider Ownership

NASDAQ SPRO
$1.17 -0.05 (-4.10%)
At close: Oct 21, 2026 · 4:00 PM EDT

Insider Holdings by Owner

9.81Mn Shares

Insider Ownership Statistics

as of 30 Sep, 2026
Insider Ownership
8.50%
▲+0.279% pp QoQ
Shares Held by Insiders
4.94Mn
filed for Sep 2026
▲+3.39% QoQ
Shares Outstanding
58.15Mn
58,146,910 shares
Direct Holdings
4.94Mn
Indirect: 0
Net Shares Traded (QoQ)
+162.31K
net buying in Sep 2026
Insiders Holding Shares
17
with Form 4 holdings on file

Shares Owned by Insiders

Shares held % of outstanding
Latest —
Average ownership —
Peak ownership —

Shares Purchased/Sold by Insiders

Bought Sold
Latest quarter —
Net over range —
Buying quarters —

Insider Ownership Summary

Over the trailing 12 months, SPRO insiders sold $552,042 worth of shares (237.11K shares) in open-market trades, with no open-market purchases.

Form 4 Holdings

Insiders Holding SPRO

Insiders 17
Shares held 9.81Mn
Of outstanding 16.87%
# Insider Position Direct Indirect Total Share of Insiders Last Filed
1 Capital Management, Llc Aquilo TenPercentOwner 0 3,419,435 3,419,435 34.9% 26 Sep, 2022
2 Sath Shukla Ceo President 1,736,883 0 1,736,883 17.7% 05 Feb, 2025
3 Esther Rajavelu Cfo Cbo 986,851 0 986,851 10.1% 09 Feb, 2026
4 Kamal Hamed Chief Medical Officer 788,117 0 788,117 8.0% 05 Feb, 2024
5 Timothy Keutzer Chief Operating Officer 742,506 0 742,506 7.6% 09 Feb, 2026
6 Ankit Mahadevia Ceo And President 703,294 0 703,294 7.2% 02 Sep, 2025
7 Tamara L Joseph Chief Legal Officer 531,615 0 531,615 5.4% 05 Feb, 2024
8 Debra Zack Chief Medical Officer 162,311 0 162,311 1.7% 06 Aug, 2026
9 Milind Deshpande Director 101,454 0 101,454 1.0% 25 Jun, 2026
10 Patrick V.J.J. Vink Director 85,000 0 85,000 0.9% 25 Jun, 2026
11 John C Jr Pottage Director 85,000 0 85,000 0.9% 25 Jun, 2026
12 Cynthia Smith Director 85,000 0 85,000 0.9% 25 Jun, 2026
13 Frank E Thomas Director 85,000 0 85,000 0.9% 25 Jun, 2026
14 Kathleen Tregoning Director 85,000 0 85,000 0.9% 25 Jun, 2026
15 Scott Thomas Jackson Director 85,000 0 85,000 0.9% 25 Jun, 2026
16 Cristina Larkin Chief Operating Officer 63,581 0 63,581 0.6% 03 Feb, 2022
17 David A. Melnick Chief Medical Officer 62,081 0 62,081 0.6% 03 Feb, 2022

Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.

Form 4 Filings

338 Insider Transactions

Source SEC Form 4
Latest quarter Sep 2026
Download Data
Date Insider Position Transaction Shares Price Value Shares Held After Ownership
03 Aug, 2026 Debra Zack Chief Medical Officer Acquired A 162,311 $0.00 $0 162,311 Direct
03 Aug, 2026 Debra Zack Chief Medical Officer Acquired A 324,675 $0.00 $0 324,675 Direct
23 Jun, 2026 John C Jr Pottage Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Milind Deshpande Director Acquired A 10,000 $0.00 $0 101,454 Direct
23 Jun, 2026 Cynthia Smith Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Scott Thomas Jackson Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Kathleen Tregoning Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Patrick V.J.J. Vink Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Frank E Thomas Director Acquired A 10,000 $0.00 $0 85,000 Direct
23 Jun, 2026 Kathleen Tregoning Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 Frank E Thomas Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 Patrick V.J.J. Vink Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 Cynthia Smith Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 Milind Deshpande Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 John C Jr Pottage Director Acquired A 20,000 $0.00 $0 20,000 Direct
23 Jun, 2026 Scott Thomas Jackson Director Acquired A 20,000 $0.00 $0 20,000 Direct
04 May, 2026 Esther Rajavelu Officer Disposed S 25,240 $2.51 $63.35K 986,851 Direct
06 Feb, 2026 Esther Rajavelu Officer Disposed S 37,101 $2.36 $87.56K 1,062,907 Direct
06 Feb, 2026 Timothy Keutzer Chief Operating Officer Disposed S 18,652 $2.36 $44.02K 742,506 Direct
06 Feb, 2026 Esther Rajavelu Officer Disposed S 50,816 $2.36 $119.93K 1,012,091 Direct