Vertex Pharmaceuticals (VRTX) Operating Margin (2009 - 2026)
Vertex Pharmaceuticals (VRTX) posted quarterly Operating Margin of 38.1% for Q1 2026, up 1536.0% year-over-year from 2.33% in Q1 2025, and up 0.8% quarter-over-quarter from 37.8% in Q4 2025.
Vertex Pharmaceuticals (VRTX) Operating Margin (2009 - 2026) Analysis & Trends
Vertex Pharmaceuticals' Operating Margin history runs 18 years deep, the most recent figure standing at 38.1% for Q1 2026.
- In Q1 2026, Operating Margin rose 1536.0% year-over-year to 38.1%; the TTM figure through Mar 2026 stood at 38.31% (up 4500.0% YoY), while the FY2025 annual figure was 34.77%, up 3689.0% from the prior year.
- Operating Margin for Q1 2026 stood at 38.1%, up from 37.8% in the prior quarter.
- The five-year high for Operating Margin was 50.37% in Q2 2022, with the low at 132.85% in Q2 2024.
- The 5-year median for Operating Margin is 39.26% (2023), against an average of 29.95%.
- The sharpest annual moves came in 2024 and 2025: Operating Margin sank 17402 bps in 2024, then soared 17168 bps in 2025.
- Vertex Pharmaceuticals' Operating Margin stood at 44.88% in 2022, then decreased by 13 bps to 39.26% in 2023, then decreased by 10 bps to 35.23% in 2024, then rose by 7 bps to 37.8% in 2025, then grew by 1 bps to 38.1% in 2026.
- Business Quant data shows VRTX's Operating Margin at 38.1% in Q1 2026, 37.8% in Q4 2025, and 38.56% in Q3 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 31.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 19.06% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -105.20% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 19.75% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 17.93% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -0.36% |
| 10 | Roivant Sciences | 26.16 Bn | 26.85 Bn | 1.16 Mn | -25,380.93% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | 37.40% |
| Mar 31, 2026 | 38.10% |
| Dec 31, 2025 | 37.80% |
| Sep 30, 2025 | 38.56% |
| Jun 30, 2025 | 38.83% |
| Mar 31, 2025 | 22.75% |
| Dec 31, 2024 | 35.23% |
| Sep 30, 2024 | 40.27% |
| Jun 30, 2024 | -132.85% |
| Mar 31, 2024 | 42.35% |
| Dec 31, 2023 | 39.26% |
| Sep 30, 2023 | 41.80% |
| Jun 30, 2023 | 41.17% |
| Mar 31, 2023 | 32.80% |
| Dec 31, 2022 | 44.88% |
| Sep 30, 2022 | 48.27% |
| Jun 30, 2022 | 50.37% |
| Mar 31, 2022 | 49.63% |
| Dec 31, 2021 | 42.35% |
| Sep 30, 2021 | 53.15% |