Vertex Pharmaceuticals (VRTX) Operating Margin (2009 - 2026)
Vertex Pharmaceuticals (VRTX) recorded Operating Margin of 37.40% in Q2 2026, down 1.43 percentage points from 38.83% a year earlier and down 0.70 percentage points from the prior quarter.
Powered by 
Analysis
Vertex Pharmaceuticals (VRTX) Operating Margin (2009 - 2026) Analysis & Trends
On a TTM basis, Vertex Pharmaceuticals' Operating Margin came in at 37.95% as of Jun 30, 2026, up 3.59 percentage points year-over-year; for FY2025, it was 34.77%, up 36.89 percentage points from FY2024.
- Annual Operating Margin has a five-year change of -11.25 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -2.11% in FY2024 (-40.94 pp), 38.83% in FY2023 (-9.40 pp), 48.23% in FY2022 (+11.50 pp) and 36.73% in FY2021 (-9.30 pp).
- The Q2 2026 figure is the lowest quarterly Operating Margin since Q1 2025.
- On a year-over-year basis, Operating Margin rose in three of the last eight quarters, with an average year-over-year change of +20.16 percentage points.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 171.68 percentage points in Q2 2025, against a drop of 174.02 percentage points in Q2 2024 at the low end.
- Per Business Quant, the preceding three quarters came in at 38.10% (Q1 2026), 37.80% (Q4 2025) and 38.56% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,122.91 Bn | 1,091.50 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 615.09 Bn | 533.62 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 504.75 Bn | 477.86 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 360.18 Bn | 314.55 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 292.05 Bn | 256.04 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 256.09 Bn | 229.78 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 233.63 Bn | 189.02 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 194.49 Bn | 168.69 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 168.35 Bn | 114.99 Bn | 10.94 Bn | 28.37% |
| 10 | Vertex Pharmaceuticals | 126.70 Bn | 98.70 Bn | 2.84 Bn | 37.40% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 37.40% |
| Mar 31, 2026 | 38.10% |
| Dec 31, 2025 | 37.80% |
| Sep 30, 2025 | 38.56% |
| Jun 30, 2025 | 38.83% |
| Mar 31, 2025 | 22.75% |
| Dec 31, 2024 | 35.23% |
| Sep 30, 2024 | 40.27% |
| Jun 30, 2024 | -132.85% |
| Mar 31, 2024 | 42.35% |
| Dec 31, 2023 | 39.26% |
| Sep 30, 2023 | 41.80% |
| Jun 30, 2023 | 41.17% |
| Mar 31, 2023 | 32.80% |
| Dec 31, 2022 | 44.88% |
| Sep 30, 2022 | 48.27% |
| Jun 30, 2022 | 50.37% |
| Mar 31, 2022 | 49.63% |
| Dec 31, 2021 | 42.35% |
| Sep 30, 2021 | 53.15% |
API Access
Vertex Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=VRTX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "VRTX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=VRTX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();