Xilio Therapeutics XLO Institutional Ownership

NASDAQ XLO

$8.40 -0.14 (-1.64%)

As of: Oct 21, 2026 · 3:59 PM EDT

Institutions by Trading Activity

27 Institutions

Increased 15 55.6%

Unchanged 8 29.6%

Reduced 4 14.8%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

17.56%

▲+1.54 pp QoQ

Shares Held by Institutions

3.41Mn

of 19.40Mn outstanding

▲+30.08% QoQ

Shares Outstanding

19.40Mn

16.00Mn held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+3 vs prior quarter

Net Shares Added (QoQ)

+787.82K

accumulated since last quarter

Value of Holdings

$29.10Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Xilio Therapeutics, Inc. (NASDAQ:XLO) had 27 institutional holders reporting a position on Form 13F for the quarter ended June 30, 2026.

Their combined stake equaled 17.56% of outstanding shares in Q2 2026, up from 16.02% in Q1 2026.
Total holdings of XLO shares rose 30.08% from Q1 2026, and the holder count fell 20.59% from Q2 2025.
Of the 27 holders of XLO in Q2 2026, 15 added to their positions, 4 reduced their stakes and 8 left their positions unchanged.
The aggregate institutional position in Xilio Therapeutics was 3.41Mn shares at the end of Q2 2026, up 787.82K from the prior quarter and up 1.81Mn from a year earlier.
As of June 30, 2026, Bain Capital Life Sciences Investors, LLC held the largest stake in Xilio Therapeutics with 664.02K shares, or 3.42% of shares outstanding.
The biggest increases in XLO positions during Q2 2026 came from Stonepine Capital Management, LLC (+161.83K shares), Vanguard Capital Management LLC (+54.86K shares), Renaissance Technologies LLC (+14.59K shares) and Geode Capital Management, LLC (+1.86K shares).
The largest position reductions in XLO for Q2 2026 were by Vanguard Fiduciary Trust Co (-5.88K shares), UBS Group AG (-4.02K shares), GSA Capital Partners LLP (-3.36K shares) and Morgan Stanley (-539 shares).
Per Business Quant data, the 10 largest holders of Xilio Therapeutics at the end of Q2 2026 were Bain Capital Life Sciences Investors, LLC (664.02K shares), Gilead Sciences, Inc. (650.39K shares), OrbiMed Advisors LLC (592.3K shares), Frazier Life Sciences Management, L.P. (422.5K shares), Stonepine Capital Management, LLC (225.99K shares), Vanguard Capital Management LLC (178.52K shares), Sio Capital Management, LLC (152.46K shares), Adage Capital Partners GP, L.L.C. (111.54K shares), Merck & Co., Inc. (105.98K shares) and Renaissance Technologies LLC (64.15K shares).

Form 13F Holdings

27 Institutional Holders

Report period 30 Jun, 2026

Total shares held 3.41Mn

Of outstanding 17.56%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	Bain Capital Life Sciences Investors, LLC	0001703031	664,021	3.42%	0	0.00%	$6.36Mn
2	Gilead Sciences, Inc.	0000882095	650,389	3.35%	0	0.00%	$6.23Mn
3	ORBIMED ADVISORS LLC	0001055951	592,300	3.05%	▲592,300	0.00%	$5.67Mn
4	Frazier Life Sciences Management, L.P.	0001892134	422,505	2.18%	0	0.00%	$4.05Mn
5	Stonepine Capital Management, LLC	0001440771	225,994	1.16%	▲161,832	+252.22%	$2.17Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	178,517	0.92%	▲54,857	+44.36%	$1.71Mn
7	Sio Capital Management, LLC	0001482416	152,464	0.79%	0	0.00%	$1.46Mn
8	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	111,541	0.57%	▲111,541	0.00%	$1.07Mn
9	Merck & Co., Inc.	0000310158	105,982	0.55%	0	0.00%	$1.02Mn
10	RENAISSANCE TECHNOLOGIES LLC	0001037389	64,153	0.33%	▲14,587	+29.43%	$614.59K
11	Morgan Stanley	0000895421	56,954	0.29%	▼539	-0.94%	$545.62K
12	GEODE CAPITAL MANAGEMENT, LLC	0001214717	39,055	0.20%	▲1,858	+5.00%	$374.17K
13	CITADEL ADVISORS LLC	0001423053	25,950	0.13%	▲25,950	0.00%	$248.60K
14	VANGUARD FIDUCIARY TRUST CO	0000933478	22,594	0.12%	▼5,881	-20.65%	$216.45K
15	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0001107261	17,544	0.09%	▲17,544	0.00%	$168.07K
16	TWO SIGMA INVESTMENTS, LP	0001179392	14,544	0.07%	▲14,544	0.00%	$139.33K
17	Velan Capital Investment Management LP	0001848809	14,285	0.07%	0	0.00%	$136.85K
18	GSA CAPITAL PARTNERS LLP	0001362033	13,590	0.07%	▼3,356	-19.80%	$130
19	State Street Corp	0000093751	13,311	0.07%	0	0.00%	$127.52K
20	PRELUDE CAPITAL MANAGEMENT, LLC	0001387508	11,600	0.06%	▲11,600	0.00%	$111.13K

Showing 1 to 20 of 27 holders