Tyra Biosciences TYRA Institutional Ownership

Updated Oct 11, 2026

Tyra Biosciences, Inc. (NASDAQ:TYRA) was held by 171 institutional investors that filed 13F reports for the quarter ended June 30, 2026.

• Total shares held in TYRA rose 5.18% from Q1 2026; the number of holders rose 44.92% from Q2 2025.
• Of these 171 holders, 107 added to their positions, 44 reduced their stakes and 20 left their positions unchanged.
• The aggregate institutional position in Tyra Biosciences was 69.35Mn shares at the end of Q2 2026, up 3.41Mn from the prior quarter and up 13.35Mn from a year earlier.
• Ra Capital Management, L.P. held the largest position in TYRA at 12.2Mn shares as of June 30, 2026.
• The biggest increases in TYRA positions during Q2 2026 came from T. Rowe Price Associates Inc (+1.8Mn shares), FMR LLC (+1.17Mn shares), State Street Corp (+924.29K shares), BlackRock, Inc. (+814.04K shares) and Deerfield Management Company, L.P. (+468K shares).
• The biggest cuts to TYRA positions during Q2 2026 came from Barclays PLC (-813.12K shares), Commodore Capital LP (-600K shares), Nextech Invest Ltd. (-502.28K shares), BVF Inc (-500K shares) and Caligan Partners LP (-469.98K shares).
• Per Business Quant, the top 10 investors in TYRA for the quarter ended June 30, 2026 were Ra Capital Management, L.P. (12.2Mn shares), FMR LLC (8.92Mn shares), Jupiter Topco LLC (4.35Mn shares), Alta Partners Management Company, L.P. (3.82Mn shares), Nextech Invest Ltd. (3.55Mn shares), TCG Crossover Management, LLC (3.25Mn shares), BlackRock, Inc. (3.03Mn shares), T. Rowe Price Associates Inc (2.78Mn shares), State Street Corp (2.14Mn shares) and Commodore Capital LP (1.88Mn shares).