Spyre Therapeutics SYRE Institutional Ownership

NASDAQ SYRE

$92.33 -0.62 (-0.67%)

At close: Oct 22, 2026 · 4:00 PM EDT

Institutions by Trading Activity

262 Institutions

Increased 192 73.3%

Unchanged 14 5.3%

Reduced 56 21.4%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

—

13F totals exceed reported shares outstanding

Shares Held by Institutions

95.81Mn

of 84.73Mn outstanding

▲+15.26% QoQ

Shares Outstanding

84.73Mn

Institutional Investors

262

filed 13F for Jun 2026

▲+65 vs prior quarter

Net Shares Added (QoQ)

+12.69Mn

accumulated since last quarter

Value of Holdings

$8.91Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Spyre Therapeutics, Inc. (NASDAQ:SYRE) appeared in the 13F filings of 262 institutional investors for the quarter ended June 30, 2026.

Total holdings of Spyre Therapeutics shares rose 15.26% from Q1 2026, and the number of holders rose 107.94% from Q2 2025.
Among the 262 holders of Spyre Therapeutics, 192 added to their positions, 56 reduced their stakes and 14 left their positions unchanged.
The aggregate institutional position in Spyre Therapeutics was 95.81Mn shares at the end of Q2 2026, up 12.69Mn from the prior quarter and up 33.04Mn from a year earlier.
FMR LLC led 13F holders of SYRE with 13.03Mn shares as of June 30, 2026.
Among holders that already owned Spyre Therapeutics, the biggest buyers in Q2 2026 were Paradigm Biocapital Advisors LP (+1.88Mn shares), Vanguard Portfolio Management LLC (+1.74Mn shares), Capital World Investors (+1.65Mn shares), T. Rowe Price Associates Inc (+1.36Mn shares) and FMR LLC (+1.25Mn shares).
The biggest cuts to SYRE positions during Q2 2026 came from Commodore Capital LP (-1.07Mn shares), Capital International Investors (-790.93K shares), Venrock Adviser, LLC (-700K shares), Remedium Capital Partners, LLC (-443.16K shares) and Wellington Management Group LLP (-243.31K shares).
Per Business Quant, the top 10 investors in SYRE for the quarter ended June 30, 2026 were FMR LLC (13.03Mn shares), BlackRock, Inc. (6.51Mn shares), Perceptive Advisors LLC (4.32Mn shares), RTW Investments, LP (4.25Mn shares), Paradigm Biocapital Advisors LP (3.84Mn shares), Vanguard Capital Management LLC (3.45Mn shares), State Street Corp (3.06Mn shares), Venrock Adviser, LLC (2.99Mn shares), T. Rowe Price Associates Inc (2.96Mn shares) and Driehaus Capital Management LLC (2.8Mn shares).

Form 13F Holdings

264 Institutional Holders

Report period 30 Jun, 2026

Total shares held 95.81Mn

Of outstanding —

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	FMR LLC	0000315066	13,026,187	15.37%	▲1,245,163	+10.57%	$1.16Bn
2	BlackRock, Inc.	0002012383	6,506,605	7.68%	▲985,384	+17.85%	$577.66Mn
3	PERCEPTIVE ADVISORS LLC	0001224962	4,319,496	5.10%	▲536,271	+14.17%	$383.48Mn
4	RTW INVESTMENTS, LP	0001493215	4,251,996	5.02%	▲80,000	+1.92%	$377.49Mn
5	Paradigm Biocapital Advisors LP	0001855655	3,840,778	4.53%	▲1,883,512	+96.23%	$340.98Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	3,448,681	4.07%	▲391,280	+12.80%	$306.17Mn
7	State Street Corp	0000093751	3,057,416	3.61%	▲450,385	+17.28%	$271.44Mn
8	Venrock Adviser, LLC	0001615982	2,985,448	3.52%	▼700,000	-18.99%	$265.05Mn
9	PRICE T ROWE ASSOCIATES INC /MD/	0000080255	2,960,855	3.49%	▲1,362,125	+85.20%	$262.87K
10	DRIEHAUS CAPITAL MANAGEMENT LLC	0000938206	2,799,166	3.30%	▲8,381	+0.30%	$248.51Mn
11	GEODE CAPITAL MANAGEMENT, LLC	0001214717	2,562,265	3.02%	▲841,353	+48.89%	$239.26Mn
12	VANGUARD PORTFOLIO MANAGEMENT LLC	0002100121	2,330,098	2.75%	▲1,744,968	+298.22%	$206.87Mn
13	Capital World Investors	0001422849	2,315,553	2.73%	▲1,648,989	+247.39%	$205.57Mn
14	Jupiter Topco LLC	0002146052	2,206,936	2.60%	▲2,206,936	0.00%	$195.88Mn
15	TCG Crossover Management, LLC	0001839948	1,900,582	2.24%	0	0.00%	$168.73Mn
16	TANG CAPITAL MANAGEMENT LLC	0001232621	1,892,200	2.23%	0	0.00%	$167.99Mn
17	Bank Of America Corp /De/	0000070858	1,777,854	2.10%	▲549,761	+44.77%	$157.84Mn
18	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	1,722,300	2.03%	▲1,722,300	0.00%	$152.91Mn
19	WELLINGTON MANAGEMENT GROUP LLP	0000902219	1,581,505	1.87%	▼243,306	-13.33%	$140.41Mn
20	Goldman Sachs Group Inc	0000886982	1,478,059	1.74%	▲1,208,121	+447.56%	$131.22Mn

Showing 1 to 20 of 264 holders