Karyopharm Therapeutics KPTI Institutional Ownership

NASDAQ KPTI

$0.55 +0.12 (+28.68%)

At close: Oct 22, 2026 · 4:00 PM EDT

Institutions by Trading Activity

97 Institutions

Increased 66 68.0%

Unchanged 17 17.5%

Reduced 14 14.4%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

73.11%

▼-23.36 pp QoQ

Shares Held by Institutions

21.16Mn

of 28.94Mn outstanding

▲+19.77% QoQ

Shares Outstanding

28.94Mn

7.78Mn held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+20 vs prior quarter

Net Shares Added (QoQ)

+3.49Mn

accumulated since last quarter

Value of Holdings

$8.89Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) appeared in the 13F filings of 97 institutional investors for the quarter ended June 30, 2026.

These investors held 73.11% of outstanding shares in Q2 2026, down from 96.47% the quarter before.
Total holdings of Karyopharm Therapeutics shares rose 19.77% from Q1 2026, and the number of holders rose 106.38% from Q2 2025.
Among the 97 holders of Karyopharm Therapeutics, 66 added to their positions, 14 reduced their stakes and 17 left their positions unchanged.
In total, institutional investors held 21.16Mn shares of Karyopharm Therapeutics at the end of Q2 2026, up 3.49Mn from the prior quarter and up 17Mn from a year earlier.
Ra Capital Management, L.P. held the largest position in KPTI at 1.92Mn shares as of June 30, 2026, or 6.63% of shares outstanding.
Holders that added the most shares of Karyopharm Therapeutics in Q2 2026 were Acorn Capital Advisors, LLC (+1.23Mn shares), BlackRock, Inc. (+1.17Mn shares), Two Sigma Investments, LP (+544.03K shares), Goldman Sachs Group Inc (+477.08K shares) and Avidity Partners Management LP (+460.75K shares).
The biggest cuts to KPTI positions during Q2 2026 came from T. Rowe Price Investment Management, Inc. (-755.78K shares), Adage Capital Partners GP, L.L.C. (-285K shares), Affinity Asset Advisors, LLC (-187.5K shares), Jump Financial, LLC (-168.15K shares) and Millennium Management LLC (-114.89K shares).
Karyopharm Therapeutics' 10 largest institutional shareholders as of Q2 2026 were Ra Capital Management, L.P. (1.92Mn shares), Adage Capital Partners GP, L.L.C. (1.52Mn shares), Acorn Capital Advisors, LLC (1.52Mn shares), Goldman Sachs Group Inc (1.42Mn shares), BlackRock, Inc. (1.42Mn shares), Vanguard Capital Management LLC (958.98K shares), Catalio Capital Management, LP (940.86K shares), Avidity Partners Management LP (924.49K shares), T. Rowe Price Investment Management, Inc. (786.31K shares) and Two Sigma Investments, LP (695.26K shares), per Business Quant data.

Form 13F Holdings

97 Institutional Holders

Report period 30 Jun, 2026

Total shares held 21.16Mn

Of outstanding 73.11%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	RA CAPITAL MANAGEMENT, L.P.	0001346824	1,917,354	6.63%	0	0.00%	$18.73Mn
2	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	1,521,322	5.26%	▼285,000	-15.78%	$14.86Mn
3	ACORN CAPITAL ADVISORS, LLC	0002054410	1,518,113	5.25%	▲1,230,287	+427.44%	$14.83Mn
4	Goldman Sachs Group Inc	0000886982	1,424,658	4.92%	▲477,079	+50.35%	$13.92Mn
5	BlackRock, Inc.	0002012383	1,418,799	4.90%	▲1,173,900	+479.34%	$13.86Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	958,979	3.31%	▲219,234	+29.64%	$9.37Mn
7	Catalio Capital Management, LP	0001958125	940,855	3.25%	▲43,146	+4.81%	$9.19Mn
8	Avidity Partners Management LP	0001791827	924,487	3.19%	▲460,746	+99.35%	$9.03Mn
9	T. Rowe Price Investment Management, Inc.	0001897612	786,309	2.72%	▼755,781	-49.01%	$7.68K
10	TWO SIGMA INVESTMENTS, LP	0001179392	695,264	2.40%	▲544,032	+359.73%	$6.79Mn
11	Kalehua Capital Management LLC	0002106181	685,644	2.37%	▲685,644	0.00%	$6.70Mn
12	NEA Management Company, LLC	0001512848	576,780	1.99%	▲576,780	0.00%	$5.64Mn
13	GEODE CAPITAL MANAGEMENT, LLC	0001214717	531,231	1.84%	▲325,098	+157.71%	$5.19Mn
14	Ghisallo Capital Management LLC	0001825214	500,000	1.73%	▲500,000	0.00%	$4.89Mn
15	Soleus Capital Management, L.P.	0001802630	440,000	1.52%	0	0.00%	$4.30Mn
16	UBS Group AG	0001610520	353,545	1.22%	▲159,528	+82.22%	$3.45Mn
17	State Street Corp	0000093751	325,991	1.13%	▲245,249	+303.74%	$3.18Mn
18	Affinity Asset Advisors, LLC	0001773195	312,500	1.08%	▼187,500	-37.50%	$3.05Mn
19	Brevan Howard Capital Management LP	0001512857	309,817	1.07%	▲97,450	+45.89%	$3.03Mn
20	MILLENNIUM MANAGEMENT LLC	0001273087	305,676	1.06%	▼114,895	-27.32%	$2.99Mn

Showing 1 to 20 of 97 holders