Xilio Therapeutics (XLO) Operating Margin (2024 - 2026)
Xilio Therapeutics (XLO) posted Operating Margin of 111.57% for Q1 2026, down 29.01% sequentially from 86.48% in Q4 2025, and up 36116.0% YoY from N/an in Q1 2025.
Xilio Therapeutics (XLO) Operating Margin (2024 - 2026) Analysis & Trends
Xilio Therapeutics has reported Operating Margin for 3 years, with the latest figure at 111.57% in Q1 2026.
- Quarterly Operating Margin rose 36116.0% year-over-year to 111.57% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 78.98% (up 53506.0% YoY) and the FY2025 annual result came in at 95.92%, up 85903.0% from the prior year.
- Operating Margin fell to 111.57% in Q1 2026 per XLO's latest filing, from 86.48% in the prior quarter.
- Over five years, Operating Margin peaked at 10.12% in Q3 2025 and troughed at 790.55% in Q4 2024.
- A 3-year average of 365.67% and a median of 325.22% in 2025 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2025 and 2026: Operating Margin soared 70406 bps in 2025, then soared 36116 bps in 2026.
- Over 3 years, Operating Margin stood at 790.55% in 2024, then soared by 89 bps to 86.48% in 2025, then decreased by 29 bps to 111.57% in 2026.
- According to Business Quant data, Operating Margin over the past three periods registered 111.57%, 86.48%, and 10.12% for Q1 2026, Q4 2025, and Q3 2025 respectively.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.84 Bn | 131.99 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 86.48 Bn | 78.49 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 65.47 Bn | 60.29 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 60.15 Bn | 55.01 Bn | 52.00 Mn | -562.07% |
| 5 | BeOne Medicines | 42.22 Bn | 37.12 Bn | 1.53 Bn | 19.06% |
| 6 | Alnylam Pharmaceuticals | 31.67 Bn | 28.36 Bn | 992.69 Mn | 17.93% |
| 7 | BioNTech SE | 28.54 Bn | 10.14 Bn | 668.28 Mn | -35.57% |
| 8 | Insmed | 27.58 Bn | 26.42 Bn | 358.27 Mn | -0.36% |
| 9 | Royalty Pharma | 27.22 Bn | 26.38 Bn | - | 19.75% |
| 10 | Xilio Therapeutics | 176.87 Mn | 40.83 Mn | - | -18.68% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -18.68% |
| Mar 31, 2026 | -111.57% |
| Dec 31, 2025 | -86.48% |
| Sep 30, 2025 | -10.12% |
| Jun 30, 2025 | -177.71% |
| Mar 31, 2025 | -472.73% |
| Dec 31, 2024 | -790.55% |
| Sep 30, 2024 | -652.32% |
| Jun 30, 2024 | -623.84% |