Septerna (SEPN) Operating Margin (2023 - 2026)
Septerna's (SEPN) quarterly Operating Margin came in at 50.19% in Q1 2026, up 1178086.0% year-on-year from N/an in Q1 2025, and up 24.46% quarter-over-quarter from 66.44% in Q4 2025.
Septerna (SEPN) Operating Margin (2023 - 2026) Analysis & Trends
Septerna's Operating Margin history runs 4 years deep, the most recent figure standing at 50.19% for Q1 2026.
- On a quarterly basis, Operating Margin rose 1178086.0% year-over-year to 50.19% in Q1 2026; TTM through Mar 2026 was 77.09%, a 926200.0% increase from a year earlier, with the FY2025 full-year figure at 148.63%, up 736979.0% from the prior year.
- Operating Margin advanced to 50.19% in Q1 2026 per SEPN's latest filing, from 66.44% in the prior quarter.
- Across five years, Operating Margin topped out at 29082.2% in Q4 2023 and bottomed at 36484.85% in Q3 2023.
- The 4-year median for Operating Margin is 4886.44% (2024), against an average of 7084.57%.
- Biggest YoY gain for Operating Margin was 2367235 bps in 2024; the steepest drop was 4074164 bps in 2024.
- Year by year, Operating Margin stood at 29082.2% in 2023, then plunged by 140 bps to 11659.43% in 2024, then jumped by 99 bps to 66.44% in 2025, then gained by 24 bps to 50.19% in 2026.
- Per Business Quant, the three latest SEPN Operating Margin figures stand at 50.19% (Q1 2026), 66.44% (Q4 2025), and 12.16% (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 16.51% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 38.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 17.83% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 31.68% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Septerna | 1.50 Bn | 1.50 Bn | - | -50.19% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -50.19% |
| Dec 31, 2025 | -66.44% |
| Sep 30, 2025 | 12.16% |
| Jun 30, 2025 | -24,351.26% |
| Mar 31, 2025 | -11,831.05% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -12,812.50% |
| Jun 30, 2024 | -4,882.43% |
| Mar 31, 2024 | -4,886.44% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -36,484.85% |