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Asset Utilization RatioAssets AverageEBIT MarginEBITDA MarginEBT MarginEnterprise ValueEquity AverageEquity RatioFCF MarginInvested CapitalNet MarginOperating MarginReturn on AssetsReturn on Capital EmployedReturn on EquityReturn on Invested CapitalReturn on Sales

Septerna (SEPN) Operating Margin (2023 - 2025)

Septerna has reported Operating Margin over the past 3 years, most recently at 66.44% for Q4 2025.

  • Quarterly results put Operating Margin at 66.44% for Q4 2025, up 1159300.0% from a year ago — trailing twelve months through Dec 2025 was 148.63% (up 736979.0% YoY), and the annual figure for FY2025 was 148.63%, up 736979.0%.
  • Operating Margin for Q4 2025 was 66.44% at Septerna, down from 12.16% in the prior quarter.
  • Over the last five years, Operating Margin for SEPN hit a ceiling of 29082.2% in Q4 2023 and a floor of 36484.85% in Q3 2023.
  • Median Operating Margin over the past 3 years was 8272.93% (2024), compared with a mean of 7788.0%.
  • Peak annual rise in Operating Margin hit 2367235bps in 2024, while the deepest fall reached -4074164bps in 2024.
  • Septerna's Operating Margin stood at 29082.2% in 2023, then crashed by -140bps to 11659.43% in 2024, then surged by 99bps to 66.44% in 2025.
  • The last three reported values for Operating Margin were 66.44% (Q4 2025), 12.16% (Q3 2025), and 24351.26% (Q2 2025) per Business Quant data.