Septerna (SEPN) Operating Margin (2023 - 2026)
Septerna (SEPN) recorded quarterly Operating Margin of 50.19% in Q1 2026, down 128.81% quarter-over-quarter from 174.19% in Q4 2025, and up 1178086.0% on a YoY basis from N/an in Q1 2025.
Septerna (SEPN) Operating Margin (2023 - 2026) Analysis & Trends
Septerna's Operating Margin history runs 4 years deep, the most recent figure standing at 50.19% for Q1 2026.
- In Q1 2026, Operating Margin rose 1178086.0% year-over-year to 50.19%; the TTM figure through Mar 2026 stood at 3.25% (up 934235.0% YoY), while the FY2025 annual figure was 22.33%, up 749609.0% from the prior year.
- Operating Margin was 50.19% for Q1 2026 at Septerna, down from 174.19% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 29082.2% in Q4 2023 to a low of 36484.85% in Q3 2023.
- Historically, Operating Margin has averaged 7062.69% across 4 years, with a median of 4886.44% in 2024.
- Biggest YoY gain for Operating Margin was 2367235 bps in 2024; the steepest drop was 4074164 bps in 2024.
- A 4-year view of Operating Margin shows it stood at 29082.2% in 2023, then slumped by 140 bps to 11659.43% in 2024, then surged by 101 bps to 174.19% in 2025, then plunged by 129 bps to 50.19% in 2026.
- The last three Operating Margin figures came in at 50.19% (Q1 2026), 174.19% (Q4 2025), and 12.16% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 814,307.08 Bn | 814,307.05 Bn | - | - |
| 2 | Belite Bio | 55,320.00 Bn | 55,320.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,149.72 Bn | 17,149.72 Bn | - | - |
| 4 | Legend Biotech | 3,590.00 Bn | 3,589.71 Bn | 242.10 Mn | -6.43% |
| 5 | Akari Therapeutics | 1,650.72 Bn | 1,650.72 Bn | - | - |
| 6 | Evaxion A | 1,522.09 Bn | 1,522.07 Bn | - | - |
| 7 | Psyence Biomedical | 229.39 Bn | 229.38 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 113.09 Bn | 105.85 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 90.15 Bn | 90.15 Bn | - | - |
| 10 | Septerna | 1.60 Bn | 1.60 Bn | - | -50.19% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -50.19% |
| Dec 31, 2025 | 174.19% |
| Sep 30, 2025 | 12.16% |
| Jun 30, 2025 | -24,351.26% |
| Mar 31, 2025 | -11,831.05% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -12,812.50% |
| Jun 30, 2024 | -4,882.43% |
| Mar 31, 2024 | -4,886.44% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -36,484.85% |