Septerna (SEPN) Operating Margin (2023 - 2026)
Septerna (SEPN) posted Operating Margin of -62.95% for Q2 2026, up 24288.31 percentage points from -24351.26% a year earlier but down 12.80 percentage points from the prior quarter.
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Analysis
Septerna (SEPN) Operating Margin (2023 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Septerna was -44.04%, up 14027.04 percentage points year-over-year; for FY2025, it came in at -148.63%, up 7369.79 percentage points from FY2024.
- In prior years, Septerna's Operating Margin was -7518.42% in FY2024 (-8892.59 pp) and 1374.17% in FY2023.
- Quarterly Operating Margin has run from a low of -36484.85% in Q3 2023 to a high of 29082.20% in Q4 2023 over five years.
- On a year-over-year basis, Operating Margin has increased in each of the last four quarters, with an average year-over-year change of +2125.52 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q2 2026, with a gain of 24288.31 percentage points; the weakest was Q4 2024, with a drop of 40741.64 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was -50.15% (Q1 2026), -66.44% (Q4 2025) and 12.16% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Septerna | 1.81 Bn | 1.81 Bn | - | -62.95% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -62.95% |
| Mar 31, 2026 | -50.15% |
| Dec 31, 2025 | -66.44% |
| Sep 30, 2025 | 12.16% |
| Jun 30, 2025 | -24,351.26% |
| Mar 31, 2025 | -11,831.05% |
| Dec 31, 2024 | -11,659.43% |
| Sep 30, 2024 | -12,812.50% |
| Jun 30, 2024 | -4,882.43% |
| Mar 31, 2024 | -4,886.44% |
| Dec 31, 2023 | 29,082.20% |
| Sep 30, 2023 | -36,484.85% |
API Access
Septerna Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "SEPN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=SEPN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();