Rhythm Pharmaceuticals (RYTM) Operating Margin (2021 - 2026)
Rhythm Pharmaceuticals' Operating Margin came in at -42.63% for Q3 2026, up 60.02 percentage points from -102.64% a year earlier and up 25.51 percentage points from the prior quarter.
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Analysis
Rhythm Pharmaceuticals (RYTM) Operating Margin (2021 - 2026) Analysis & Trends
Over the trailing twelve months to Sep 30, 2026, Rhythm Pharmaceuticals reported Operating Margin of -66.70%, up 40.12 percentage points year-over-year; for FY2025, it was -101.19%, up 102.84 percentage points from FY2024.
- Operating Margin has increased in each of the last four years, with a four-year change of +5290.66 percentage points (FY2021 to FY2025).
- Going back by year, Operating Margin was -204.04% in FY2024 (+34.07 pp), -238.10% in FY2023 (+519.82 pp), -757.92% in FY2022 (+4633.93 pp) and -5391.85% in FY2021.
- The Q3 2026 figure represents the highest quarterly Operating Margin in data going back to Q1 2021.
- Year-over-year, Operating Margin has increased for ten consecutive quarters, with an average year-over-year change of +87.51 percentage points over the last eight quarters.
- The fastest year-over-year change in Operating Margin over five years came in Q1 2022 (a gain of 94762.58 percentage points), and the weakest in Q1 2024 (a drop of 80.68 percentage points).
- Business Quant data shows RYTM's Operating Margin at -68.14% (Q2 2026), -87.11% (Q1 2026) and -82.20% (Q4 2025) in the three quarters before Q3 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,264.65 Bn | 1,238.27 Bn | 20.46 Bn | 52.42% |
| 2 | Johnson & Johnson | 677.74 Bn | 597.60 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 517.10 Bn | 485.11 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 362.23 Bn | 325.17 Bn | 13.19 Bn | 30.89% |
| 5 | Novartis Ag | 315.90 Bn | 276.16 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 289.40 Bn | 266.24 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 249.90 Bn | 201.56 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 209.15 Bn | 184.26 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 165.88 Bn | 113.23 Bn | 12.56 Bn | 32.98% |
| 10 | Rhythm Pharmaceuticals | 7.86 Bn | 6.48 Bn | 79.96 Mn | -42.63% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -42.63% |
| Jun 30, 2026 | -68.14% |
| Mar 31, 2026 | -87.11% |
| Dec 31, 2025 | -82.20% |
| Sep 30, 2025 | -102.64% |
| Jun 30, 2025 | -93.39% |
| Mar 31, 2025 | -143.73% |
| Dec 31, 2024 | -98.63% |
| Sep 30, 2024 | -131.98% |
| Jun 30, 2024 | -139.20% |
| Mar 31, 2024 | -538.71% |
| Dec 31, 2023 | -170.28% |
| Sep 30, 2023 | -195.31% |
| Jun 30, 2023 | -242.46% |
| Mar 31, 2023 | -458.03% |
| Dec 31, 2022 | -478.99% |
| Sep 30, 2022 | -916.60% |
| Jun 30, 2022 | -497.42% |
| Mar 31, 2022 | -3,517.42% |
| Dec 31, 2021 | -2,806.22% |
API Access
Rhythm Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=RYTM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "RYTM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=RYTM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();