Prime Medicine (PRME) Operating Margin (2024 - 2026)
Prime Medicine's Operating Margin came in at -3750.87% for Q2 2026, up 1036.31 percentage points from -4787.17% a year earlier and up 2166.66 percentage points from the prior quarter.
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Analysis
Prime Medicine (PRME) Operating Margin (2024 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Prime Medicine reported Operating Margin of -4824.94%, down 708.38 percentage points year-over-year; for FY2025, it came in at -4498.06%, up 2289.30 percentage points from FY2024.
- Operating Margin carries a five-year change of -4480.17 percentage points (FY2020 to FY2025).
- Going back by year, Operating Margin was -6787.36% in FY2024.
- The Q2 2026 figure represents the highest quarterly Operating Margin since Q1 2025.
- Year-over-year, Operating Margin increased in three of the last five quarters, with an average year-over-year change of +4213.19 percentage points.
- Business Quant data shows PRME's Operating Margin at -5917.52% (Q1 2026), -5800.48% (Q4 2025) and -4405.96% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Prime Medicine | 520.52 Mn | 520.52 Mn | - | -3,750.87% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,750.87% |
| Mar 31, 2026 | -5,917.52% |
| Dec 31, 2025 | -5,800.48% |
| Sep 30, 2025 | -4,405.96% |
| Jun 30, 2025 | -4,787.17% |
| Mar 31, 2025 | -3,603.30% |
| Dec 31, 2024 | -2,025.74% |
| Sep 30, 2024 | -25,948.33% |
| Mar 31, 2024 | -8,179.53% |
API Access
Prime Medicine Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=PRME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "PRME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=PRME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();