Prime Medicine (PRME) Operating Margin (2024 - 2026)
Prime Medicine's (PRME) quarterly Operating Margin came in at 5917.52% in Q1 2026, down 231422.0% YoY from N/an in Q1 2025, and down 2.02% on a QoQ basis from 5800.48% in Q4 2025.
Prime Medicine (PRME) Operating Margin (2024 - 2026) Analysis & Trends
Prime Medicine (PRME) has 3 years of Operating Margin data on file, last reported at 5917.52% in Q1 2026.
- Quarterly Operating Margin fell 231422.0% year-over-year to 5917.52% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 5121.76% (up 24792.0% YoY) and the FY2025 annual result came in at 4498.06%, up 228930.0% from the prior year.
- Operating Margin declined to 5917.52% in Q1 2026, from 5800.48% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 2025.74% in Q4 2024 to a low of 25948.33% in Q3 2024.
- A 3-year average of 7583.5% and a median of 5293.83% in 2025 frame the typical range for Operating Margin.
- The widest YoY moves for Operating Margin: up 2154237 bps in 2025, down 377473 bps in 2025.
- Tracing PRME's Operating Margin over 3 years: stood at 2025.74% in 2024, then slumped by 186 bps to 5800.48% in 2025, then decreased by 2 bps to 5917.52% in 2026.
- The last three Operating Margin figures came in at 5917.52% (Q1 2026), 5800.48% (Q4 2025), and 4405.96% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 31.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 19.06% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -105.20% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 19.75% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 17.93% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -0.36% |
| 10 | Prime Medicine | 558.48 Mn | 558.48 Mn | - | -3,750.87% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -3,750.87% |
| Mar 31, 2026 | -5,917.52% |
| Dec 31, 2025 | -5,800.48% |
| Sep 30, 2025 | -4,405.96% |
| Jun 30, 2025 | -4,787.17% |
| Mar 31, 2025 | -3,603.30% |
| Dec 31, 2024 | -2,025.74% |
| Sep 30, 2024 | -25,948.33% |
| Mar 31, 2024 | -8,179.53% |