Prime Medicine (PRME) Operating Margin (2024 - 2026)
Prime Medicine (PRME) reported Operating Margin of 5917.52% for Q1 2026, down 231422.0% on a YoY basis from N/an in Q1 2025, and down 2.02% quarter-over-quarter from 5800.48% in Q4 2025.
Prime Medicine (PRME) Operating Margin (2024 - 2026) Analysis & Trends
Prime Medicine has reported Operating Margin for 3 years, with the latest figure at 5917.52% in Q1 2026.
- For the quarter ending Q1 2026, Operating Margin fell 231422.0% year-over-year to 5917.52%; the trailing twelve-month figure through Mar 2026 stood at 5121.76% (up 24792.0% YoY), and the FY2025 full-year result was 4498.06%, up 228930.0% from the prior year.
- Operating Margin for Q1 2026 stood at 5917.52%, down from 5800.48% in the prior quarter.
- The five-year high for Operating Margin was 2025.74% in Q4 2024, with the low at 25948.33% in Q3 2024.
- Historically, Operating Margin has averaged 7583.5% across 3 years, with a median of 5293.83% in 2025.
- The largest YoY upside for Operating Margin was 2154237 bps in 2025 against a maximum downside of 377473 bps in 2025.
- Prime Medicine's Operating Margin stood at 2025.74% in 2024, then slumped by 186 bps to 5800.48% in 2025, then decreased by 2 bps to 5917.52% in 2026.
- The last three Operating Margin figures came in at 5917.52% (Q1 2026), 5800.48% (Q4 2025), and 4405.96% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Prime Medicine | 572.02 Mn | 572.02 Mn | - | -5,917.52% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -5,917.52% |
| Dec 31, 2025 | -5,800.48% |
| Sep 30, 2025 | -4,405.96% |
| Jun 30, 2025 | -4,787.17% |
| Mar 31, 2025 | -3,603.30% |
| Dec 31, 2024 | -2,025.74% |
| Sep 30, 2024 | -25,948.33% |
| Mar 31, 2024 | -8,179.53% |