Krystal Biotech (KRYS) Operating Margin (2023 - 2026)

Krystal Biotech (KRYS) reported Operating Margin of 46.12% for Q1 2026, up 501.0% on a YoY basis from 7.67% in Q1 2025, and up 11.59% sequentially from 41.33% in Q4 2025.

Krystal Biotech (KRYS) Operating Margin (2023 - 2026) Analysis & Trends

Krystal Biotech (KRYS) has 4 years of Operating Margin data on file, last reported at 46.12% in Q1 2026.

  • For the quarter ending Q1 2026, Operating Margin rose 501.0% year-over-year to 46.12%; the trailing twelve-month figure through Mar 2026 stood at 42.8% (up 1022.0% YoY), and the FY2025 full-year result was 41.45%, up 1882.0% from the prior year.
  • Operating Margin improved to 46.12% in Q1 2026, from 41.33% in the prior quarter.
  • In the past five years, Operating Margin ranged from a high of 46.12% in Q1 2026 to a low of 303.8% in Q3 2023.
  • A 4-year average of 1.33% and a median of 40.93% in 2025 frame the typical range for Operating Margin.
  • Across the five-year window, Operating Margin surged 33060 bps in 2024 and tumbled 406 bps in 2025, its largest moves.
  • Tracing KRYS's Operating Margin over 4 years: stood at 7.71% in 2023, then jumped by 489 bps to 45.4% in 2024, then fell by 9 bps to 41.33% in 2025, then advanced by 12 bps to 46.12% in 2026.
  • Business Quant data shows KRYS's Operating Margin at 46.12% in Q1 2026, 41.33% in Q4 2025, and 42.3% in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Operating Margin (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 16.51%
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 38.10%
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 17.83%
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 30.35%
9 Revolution Medicines 37.37 Bn 37.37 Bn - -
10 Krystal Biotech 9.84 Bn 9.02 Bn 110.08 Mn 46.12%

Historic Data

Download Data
DateValue
Mar 31, 2026 46.12%
Dec 31, 2025 41.33%
Sep 30, 2025 42.30%
Jun 30, 2025 40.93%
Mar 31, 2025 41.11%
Dec 31, 2024 45.40%
Sep 30, 2024 26.80%
Jun 30, 2024 12.18%
Mar 31, 2024 -14.77%
Dec 31, 2023 7.71%
Sep 30, 2023 -303.80%