Krystal Biotech KRYS
NASDAQ KRYS
$357.99 -13.48 (-3.63%)
As of: Sep 4, 2026 · 3:59 PM EDT

Krystal Biotech (KRYS) Operating Margin (2023 - 2026)

Krystal Biotech (KRYS) posted quarterly Operating Margin of 49.0% for Q2 2026, up 798.0% year-over-year from 5.46% in Q2 2025, and up 6.23% on a QoQ basis from 46.12% in Q1 2026.

Analysis

Krystal Biotech (KRYS) Operating Margin (2023 - 2026) Analysis & Trends

Krystal Biotech has reported Operating Margin for 4 years, with the latest figure at 49.0% in Q2 2026.

  • Operating Margin for Q2 2026 came in at 49.0%, up 798.0% year-over-year; the trailing twelve-month figure through Jun 2026 was 44.89% (up 605.0% YoY), and the FY2025 annual result was 41.45%, up 1882.0% from the prior year.
  • Operating Margin grew to 49.0% in Q2 2026, from 46.12% in the prior quarter.
  • Over five years, Operating Margin peaked at 49.0% in Q2 2026 and troughed at 303.8% in Q3 2023.
  • A 4-year average of 2.87% and a median of 41.06% in 2025 frame the typical range for Operating Margin.
  • The widest annual swing landed in 2024, when Operating Margin surged 33060 bps; it then sank 408 bps in 2025.
  • A 4-year view of Operating Margin shows it stood at 7.71% in 2023, then jumped by 489 bps to 45.41% in 2024, then retreated by 9 bps to 41.33% in 2025, then advanced by 19 bps to 49.0% in 2026.
  • Per Business Quant data, the three most recent Operating Margin figures were 49.0% in Q2 2026, 46.12% in Q1 2026, and 41.33% in Q4 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Operating Margin (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 37.40%
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 30.15%
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 32.54%
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -562.07%
5 Revolution Medicines 44.33 Bn 44.33 Bn - -
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 19.06%
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 17.93%
8 Royalty Pharma 28.45 Bn 27.61 Bn - 19.75%
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -0.36%
10 Krystal Biotech 10.61 Bn 9.76 Bn 112.79 Mn 49.00%
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 49.00%
Mar 31, 2026 46.12%
Dec 31, 2025 41.33%
Sep 30, 2025 42.30%
Jun 30, 2025 41.02%
Mar 31, 2025 41.10%
Dec 31, 2024 45.41%
Sep 30, 2024 26.80%
Jun 30, 2024 12.18%
Mar 31, 2024 -14.75%
Dec 31, 2023 7.71%
Sep 30, 2023 -303.80%