Krystal Biotech (KRYS) Operating Margin (2023 - 2026)
Krystal Biotech (KRYS) posted Operating Margin of 49.00% for Q2 2026, up 7.98 percentage points from 41.02% a year earlier and up 2.87 percentage points from the prior quarter.
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Analysis
Krystal Biotech (KRYS) Operating Margin (2023 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Krystal Biotech was 44.89%, up 6.05 percentage points year-over-year; for FY2025, it came in at 41.45%, up 18.82 percentage points from FY2024.
- In prior years, Krystal Biotech's Operating Margin was 22.63% in FY2024 (+238.84 pp) and -216.21% in FY2023.
- The Q2 2026 figure stands as the highest quarterly Operating Margin in data going back to Q3 2023.
- On a year-over-year basis, Operating Margin increased in seven of the last eight quarters, with an average year-over-year change of +59.68 percentage points.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q3 2024, with a gain of 330.60 percentage points; the weakest was Q4 2025, with a drop of 4.08 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was 46.12% (Q1 2026), 41.33% (Q4 2025) and 42.30% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Krystal Biotech | 9.98 Bn | 6.75 Bn | 112.79 Mn | 49.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 49.00% |
| Mar 31, 2026 | 46.12% |
| Dec 31, 2025 | 41.33% |
| Sep 30, 2025 | 42.30% |
| Jun 30, 2025 | 41.02% |
| Mar 31, 2025 | 41.10% |
| Dec 31, 2024 | 45.41% |
| Sep 30, 2024 | 26.80% |
| Jun 30, 2024 | 12.18% |
| Mar 31, 2024 | -14.75% |
| Dec 31, 2023 | 7.71% |
| Sep 30, 2023 | -303.80% |
API Access
Krystal Biotech Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=KRYS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "KRYS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=KRYS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();