Krystal Biotech (KRYS) Operating Margin (2023 - 2026)
Krystal Biotech recorded quarterly Operating Margin of 46.14% in Q1 2026, up 11.63% quarter-over-quarter from 41.34% in Q4 2025, and up 503.0% year-over-year from 7.65% in Q1 2025.
Krystal Biotech's Operating Margin history runs 4 years deep, the most recent figure standing at 46.14% for Q1 2026.
- In Q1 2026, Operating Margin rose 503.0% year-over-year to 46.14%; the TTM figure through Mar 2026 stood at 42.81% (up 1022.0% YoY), while the FY2025 annual figure was 41.45%, up 1882.0% from the prior year.
- Operating Margin came in at 46.14% for Q1 2026 at Krystal Biotech, up from 41.34% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 46.14% in Q1 2026 to a low of 303.8% in Q3 2023.
- A 4-year average of 1.33% and a median of 40.94% in 2025 frame the typical range for Operating Margin.
- Across the five-year window, Operating Margin soared 33060 bps in 2024 and tumbled 407 bps in 2025, its largest moves.
- Krystal Biotech's Operating Margin stood at 7.71% in 2023, then surged by 489 bps to 45.41% in 2024, then dropped by 9 bps to 41.34% in 2025, then climbed by 12 bps to 46.14% in 2026.
- According to Business Quant data, Operating Margin over the past three periods registered 46.14%, 41.34%, and 42.3% for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 17.83% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 23.02% |
| 10 | Krystal Biotech | 9.05 Bn | 8.23 Bn | 110.03 Mn | 46.14% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 46.14% |
| Dec 31, 2025 | 41.34% |
| Sep 30, 2025 | 42.30% |
| Jun 30, 2025 | 40.94% |
| Mar 31, 2025 | 41.11% |
| Dec 31, 2024 | 45.41% |
| Sep 30, 2024 | 26.80% |
| Jun 30, 2024 | 12.18% |
| Mar 31, 2024 | -14.75% |
| Dec 31, 2023 | 7.71% |
| Sep 30, 2023 | -303.80% |