Krystal Biotech (KRYS) Operating Margin (2023 - 2026)
Krystal Biotech (KRYS) posted quarterly Operating Margin of 49.0% for Q2 2026, up 798.0% year-over-year from 5.46% in Q2 2025, and up 6.23% on a QoQ basis from 46.12% in Q1 2026.
Analysis
Krystal Biotech (KRYS) Operating Margin (2023 - 2026) Analysis & Trends
Krystal Biotech has reported Operating Margin for 4 years, with the latest figure at 49.0% in Q2 2026.
- Operating Margin for Q2 2026 came in at 49.0%, up 798.0% year-over-year; the trailing twelve-month figure through Jun 2026 was 44.89% (up 605.0% YoY), and the FY2025 annual result was 41.45%, up 1882.0% from the prior year.
- Operating Margin grew to 49.0% in Q2 2026, from 46.12% in the prior quarter.
- Over five years, Operating Margin peaked at 49.0% in Q2 2026 and troughed at 303.8% in Q3 2023.
- A 4-year average of 2.87% and a median of 41.06% in 2025 frame the typical range for Operating Margin.
- The widest annual swing landed in 2024, when Operating Margin surged 33060 bps; it then sank 408 bps in 2025.
- A 4-year view of Operating Margin shows it stood at 7.71% in 2023, then jumped by 489 bps to 45.41% in 2024, then retreated by 9 bps to 41.33% in 2025, then advanced by 19 bps to 49.0% in 2026.
- Per Business Quant data, the three most recent Operating Margin figures were 49.0% in Q2 2026, 46.12% in Q1 2026, and 41.33% in Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -562.07% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 19.06% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 17.93% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 19.75% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -0.36% |
| 10 | Krystal Biotech | 10.61 Bn | 9.76 Bn | 112.79 Mn | 49.00% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 49.00% |
| Mar 31, 2026 | 46.12% |
| Dec 31, 2025 | 41.33% |
| Sep 30, 2025 | 42.30% |
| Jun 30, 2025 | 41.02% |
| Mar 31, 2025 | 41.10% |
| Dec 31, 2024 | 45.41% |
| Sep 30, 2024 | 26.80% |
| Jun 30, 2024 | 12.18% |
| Mar 31, 2024 | -14.75% |
| Dec 31, 2023 | 7.71% |
| Sep 30, 2023 | -303.80% |