Krystal Biotech KRYS Institutional Ownership

NASDAQ KRYS

$322.17 -3.25 (-1.00%)

At close: Oct 21, 2026 · 4:00 PM EDT

Institutions by Trading Activity

420 Institutions

Increased 270 64.3%

Unchanged 44 10.5%

Reduced 106 25.2%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

99.85%

▲+3.83 pp QoQ

Shares Held by Institutions

29.55Mn

of 29.60Mn outstanding

▲+4.56% QoQ

Shares Outstanding

29.60Mn

45.67K held outside 13F filers

Institutional Investors

420

filed 13F for Jun 2026

▲+55 vs prior quarter

Net Shares Added (QoQ)

+1.29Mn

accumulated since last quarter

Value of Holdings

$9.62Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Krystal Biotech, Inc. (NASDAQ:KRYS) had 420 institutional holders reporting a position on Form 13F for the quarter ended June 30, 2026.

Their combined stake equaled 99.85% of outstanding shares in Q2 2026, up from 96.01% in Q1 2026.
Total holdings of KRYS shares rose 4.56% from Q1 2026, and the holder count rose 54.41% from Q2 2025.
Looking at the 420 holders of KRYS individually, 270 added to their positions, 106 reduced their stakes and 44 left their positions unchanged.
Institutional investors held 29.55Mn shares of Krystal Biotech in total at the end of Q2 2026, up 1.29Mn from the prior quarter and up 2.16Mn from a year earlier.
As of June 30, 2026, FMR LLC held the largest stake in Krystal Biotech with 4.42Mn shares, or 14.93% of shares outstanding.
Among holders that already owned Krystal Biotech, the biggest buyers in Q2 2026 were BlackRock, Inc. (+240.98K shares), T. Rowe Price Associates Inc (+202.33K shares), William Blair Investment Management, LLC (+162.97K shares), Vanguard Portfolio Management LLC (+118.18K shares) and Goldman Sachs Group Inc (+83.89K shares).
The largest position reductions in KRYS for Q2 2026 were by Bellevue Group AG (-404.25K shares), Soleus Capital Management, L.P. (-213.83K shares), Braidwell LP (-53.45K shares), Capital World Investors (-46.88K shares) and Redmile Group, LLC (-41.5K shares).
Per Business Quant, the top 10 investors in KRYS for the quarter ended June 30, 2026 were FMR LLC (4.42Mn shares), BlackRock, Inc. (4.18Mn shares), Avoro Capital Advisors LLC (2.89Mn shares), Vanguard Portfolio Management LLC (1.57Mn shares), State Street Corp (1.35Mn shares), Vanguard Capital Management LLC (1.24Mn shares), Soleus Capital Management, L.P. (939.25K shares), Capital World Investors (777.84K shares), Geode Capital Management, LLC (698.99K shares) and T. Rowe Price Associates Inc (687.4K shares).

Form 13F Holdings

421 Institutional Holders

Report period 30 Jun, 2026

Total shares held 29.55Mn

Of outstanding 99.85%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	FMR LLC	0000315066	4,418,197	14.93%	▲44,210	+1.01%	$1.64Bn
2	BlackRock, Inc.	0002012383	4,181,432	14.13%	▲240,976	+6.12%	$1.55Bn
3	Avoro Capital Advisors LLC	0001633313	2,888,888	9.76%	0	0.00%	$1.07Bn
4	VANGUARD PORTFOLIO MANAGEMENT LLC	0002100121	1,574,905	5.32%	▲118,178	+8.11%	$585.34Mn
5	State Street Corp	0000093751	1,351,158	4.57%	▲36,724	+2.79%	$502.20Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	1,240,567	4.19%	▲75,243	+6.46%	$461.08Mn
7	Soleus Capital Management, L.P.	0001802630	939,254	3.17%	▼213,833	-18.54%	$349.09Mn
8	Capital World Investors	0001422849	777,843	2.63%	▼46,877	-5.68%	$289.10Mn
9	GEODE CAPITAL MANAGEMENT, LLC	0001214717	698,993	2.36%	▲55,018	+8.54%	$259.84Mn
10	PRICE T ROWE ASSOCIATES INC /MD/	0000080255	687,400	2.32%	▲202,326	+41.71%	$255.49K
11	Hood River Capital Management LLC	0001578177	663,375	2.24%	▲43,789	+7.07%	$246.56Mn
12	Redmile Group, LLC	0001425738	632,005	2.14%	▼41,500	-6.16%	$234.90Mn
13	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	0001644956	570,153	1.93%	▲162,975	+40.03%	$211.91Mn
14	Frazier Life Sciences Management, L.P.	0001892134	481,307	1.63%	0	0.00%	$178.89Mn
15	DIMENSIONAL FUND ADVISORS LP	0000354204	476,038	1.61%	▲7,048	+1.50%	$176.94Mn
16	FIRST TRUST ADVISORS LP	0001125816	324,900	1.10%	▼25,621	-7.31%	$120.76Mn
17	Invesco Ltd.	0000914208	324,755	1.10%	▲73,382	+29.19%	$120.70Mn
18	Goldman Sachs Group Inc	0000886982	298,841	1.01%	▲83,892	+39.03%	$111.07Mn
19	Northern Trust Corp	0000073124	283,784	0.96%	▲31,321	+12.41%	$105.47Mn
20	Franklin Templeton Inc	0000038777	261,917	0.88%	▲82,652	+46.11%	$97.35Mn

Showing 1 to 20 of 421 holders