Anaptysbio (ANAB) Operating Margin (2016 - 2026)
Anaptysbio (ANAB) posted Operating Margin of 135.53% for Q1 2026, down 251.94% on a QoQ basis from 89.2% in Q4 2025, and down 3637.0% year-over-year from 3.83% in Q1 2025.
Anaptysbio (ANAB) Operating Margin (2016 - 2026) Analysis & Trends
Anaptysbio's Operating Margin history runs 11 years deep, the most recent figure standing at 135.53% for Q1 2026.
- Quarterly Operating Margin fell 3637.0% year-over-year to 135.53% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 23.61% (up 15097.0% YoY) and the FY2025 annual result came in at 20.42%, up 14635.0% from the prior year.
- Operating Margin was 135.53% for Q1 2026 at Anaptysbio, down from 89.2% in the prior quarter.
- Across five years, Operating Margin topped out at 89.2% in Q4 2025 and bottomed at 3273.09% in Q1 2022.
- A 5-year average of 923.92% and a median of 467.91% in 2023 frame the typical range for Operating Margin.
- Annual changes were most pronounced in 2022 — Operating Margin tumbled 308948 bps — and 2024, when it jumped 264367 bps.
- Anaptysbio's Operating Margin stood at 519.46% in 2022, then rose by 10 bps to 467.91% in 2023, then jumped by 92 bps to 38.68% in 2024, then jumped by 331 bps to 89.2% in 2025, then sank by 252 bps to 135.53% in 2026.
- Business Quant data shows ANAB's Operating Margin at 135.53% in Q1 2026, 89.2% in Q4 2025, and 69.41% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | - |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | - |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 16.51% |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 38.10% |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 17.83% |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | - |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 30.35% |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | - |
| 10 | Anaptysbio | 1.55 Bn | 1.27 Bn | - | -135.53% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -135.53% |
| Dec 31, 2025 | 89.20% |
| Sep 30, 2025 | 69.41% |
| Jun 30, 2025 | -117.55% |
| Mar 31, 2025 | -99.16% |
| Dec 31, 2024 | -38.68% |
| Sep 30, 2024 | -151.71% |
| Jun 30, 2024 | -367.52% |
| Mar 31, 2024 | -587.84% |
| Dec 31, 2023 | -467.91% |
| Sep 30, 2023 | -1,137.19% |
| Jun 30, 2023 | -1,160.20% |
| Mar 31, 2023 | -3,231.51% |
| Dec 31, 2022 | -519.46% |
| Sep 30, 2022 | -2,291.80% |
| Jun 30, 2022 | -2,286.10% |
| Mar 31, 2022 | -3,273.09% |
| Dec 31, 2021 | -3,081.80% |
| Sep 30, 2021 | -33.82% |
| Jun 30, 2021 | -2.67% |