Anaptysbio (ANAB) Operating Margin (2016 - 2026)
Anaptysbio (ANAB) reported Operating Margin of 135.53% for Q1 2026, down 3637.0% on a YoY basis from 3.83% in Q1 2025, and down 251.94% quarter-over-quarter from 89.2% in Q4 2025.
Anaptysbio (ANAB) Operating Margin (2016 - 2026) Analysis & Trends
Anaptysbio has reported Operating Margin for 11 years, with the latest figure at 135.53% in Q1 2026.
- For the quarter ending Q1 2026, Operating Margin fell 3637.0% year-over-year to 135.53%; the trailing twelve-month figure through Mar 2026 stood at 23.61% (up 4372.0% YoY), and the FY2025 full-year result was 20.42%, up 5383.0% from the prior year.
- Operating Margin for Q1 2026 stood at 135.53%, down from 89.2% in the prior quarter.
- The five-year high for Operating Margin was 976.29% in Q4 2023, with the low at 3273.09% in Q1 2022.
- Historically, Operating Margin has averaged 819.1% across 5 years, with a median of 367.52% in 2024.
- Annual changes were most pronounced in 2022 — Operating Margin plunged 308948 bps — and 2024, when it jumped 264367 bps.
- Anaptysbio's Operating Margin stood at 519.46% in 2022, then surged by 288 bps to 976.29% in 2023, then slumped by 69 bps to 299.12% in 2024, then slumped by 70 bps to 89.2% in 2025, then tumbled by 252 bps to 135.53% in 2026.
- The last three Operating Margin figures came in at 135.53% (Q1 2026), 89.2% (Q4 2025), and 69.41% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Anaptysbio | 1.66 Bn | 1.38 Bn | - | -135.53% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -135.53% |
| Dec 31, 2025 | 89.20% |
| Sep 30, 2025 | 69.41% |
| Jun 30, 2025 | -117.55% |
| Mar 31, 2025 | -99.16% |
| Dec 31, 2024 | 299.12% |
| Sep 30, 2024 | -151.71% |
| Jun 30, 2024 | -367.52% |
| Mar 31, 2024 | -587.84% |
| Dec 31, 2023 | 976.29% |
| Sep 30, 2023 | -1,137.19% |
| Jun 30, 2023 | -1,160.20% |
| Mar 31, 2023 | -3,231.51% |
| Dec 31, 2022 | -519.46% |
| Sep 30, 2022 | -2,291.80% |
| Jun 30, 2022 | -2,286.10% |
| Mar 31, 2022 | -3,273.09% |
| Dec 31, 2021 | -3,081.80% |
| Sep 30, 2021 | -33.82% |
| Jun 30, 2021 | -2.67% |