Anaptysbio (ANAB) Operating Margin (2016 - 2026)
Anaptysbio posted quarterly Operating Margin of 135.53% for Q1 2026, down 3637.0% year-on-year from 3.83% in Q1 2025, and down 251.94% on a QoQ basis from 89.2% in Q4 2025.
Anaptysbio (ANAB) has 11 years of Operating Margin data on file, last reported at 135.53% in Q1 2026.
- For the quarter ending Q1 2026, Operating Margin fell 3637.0% year-over-year to 135.53%; the trailing twelve-month figure through Mar 2026 stood at 23.61% (up 4372.0% YoY), and the FY2025 full-year result was 20.42%, up 5383.0% from the prior year.
- Operating Margin for Q1 2026 stood at 135.53%, down from 89.2% in the prior quarter.
- Across five years, Operating Margin topped out at 976.29% in Q4 2023 and bottomed at 3273.09% in Q1 2022.
- The 5-year median for Operating Margin is 367.52% (2024), against an average of 819.1%.
- The widest annual swing landed in 2022, when Operating Margin slumped 308948 bps; it then jumped 264367 bps in 2024.
- A 5-year view of Operating Margin shows it stood at 519.46% in 2022, then soared by 288 bps to 976.29% in 2023, then sank by 69 bps to 299.12% in 2024, then sank by 70 bps to 89.2% in 2025, then slumped by 252 bps to 135.53% in 2026.
- The last three Operating Margin figures came in at 135.53% (Q1 2026), 89.2% (Q4 2025), and 69.41% (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 1,216,509.61 Bn | 1,216,509.61 Bn | - | - |
| 2 | Alterity Therapeutics | 764,224.41 Bn | 764,224.38 Bn | - | - |
| 3 | Legend Biotech | 2,716.00 Bn | 2,715.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,248.83 Bn | 2,248.77 Bn | - | - |
| 5 | Akari Therapeutics | 1,951.18 Bn | 1,951.17 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 113.69 Bn | 106.44 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 64.16 Bn | 64.14 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 63.94 Bn | 55.18 Bn | 3.31 Bn | 17.83% |
| 9 | Alnylam Pharmaceuticals | 40.13 Bn | 37.12 Bn | 959.66 Mn | 23.02% |
| 10 | Anaptysbio | 1.60 Bn | 1.31 Bn | - | -135.53% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -135.53% |
| Dec 31, 2025 | 89.20% |
| Sep 30, 2025 | 69.41% |
| Jun 30, 2025 | -117.55% |
| Mar 31, 2025 | -99.16% |
| Dec 31, 2024 | 299.12% |
| Sep 30, 2024 | -151.71% |
| Jun 30, 2024 | -367.52% |
| Mar 31, 2024 | -587.84% |
| Dec 31, 2023 | 976.29% |
| Sep 30, 2023 | -1,137.19% |
| Jun 30, 2023 | -1,160.20% |
| Mar 31, 2023 | -3,231.51% |
| Dec 31, 2022 | -519.46% |
| Sep 30, 2022 | -2,291.80% |
| Jun 30, 2022 | -2,286.10% |
| Mar 31, 2022 | -3,273.09% |
| Dec 31, 2021 | -3,081.80% |
| Sep 30, 2021 | -33.82% |
| Jun 30, 2021 | -2.67% |
| Mar 31, 2021 | -183.61% |
| Dec 31, 2020 | 55.58% |
| Mar 31, 2020 | -102.53% |
| Dec 31, 2019 | -741.93% |
| Jun 30, 2019 | -533.14% |
| Sep 30, 2018 | -337.74% |
| Dec 31, 2017 | -238.37% |
| Jun 30, 2017 | -85.17% |
| Dec 31, 2016 | -317.40% |
| Sep 30, 2016 | -107.50% |
| Jun 30, 2016 | 59.08% |
| Mar 31, 2016 | -28.48% |