Lexicon Pharmaceuticals LXRX Institutional Ownership

NASDAQ LXRX

$1.55 0.00 (-0.32%)

As of: Oct 22, 2026 · 10:38 AM EDT

Institutions by Trading Activity

150 Institutions

Increased 82 54.7%

Unchanged 32 21.3%

Reduced 36 24.0%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

81.62%

▲+5.66 pp QoQ

Shares Held by Institutions

364.75Mn

of 446.87Mn outstanding

▲+12.79% QoQ

Shares Outstanding

446.87Mn

82.12Mn held outside 13F filers

Institutional Investors

150

filed 13F for Jun 2026

▲+14 vs prior quarter

Net Shares Added (QoQ)

+41.37Mn

accumulated since last quarter

Value of Holdings

$576.31Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX) appeared in the 13F filings of 150 institutional investors for the quarter ended June 30, 2026.

These investors held 81.62% of outstanding shares in Q2 2026, up from 75.96% the quarter before.
Total shares held in Lexicon Pharmaceuticals rose 12.79% versus Q1 2026, while the number of holders rose 22.95% versus Q2 2025.
Among the 150 holders of Lexicon Pharmaceuticals, 82 added to their positions, 36 reduced their stakes and 32 left their positions unchanged.
In total, institutional investors held 364.75Mn shares of Lexicon Pharmaceuticals at the end of Q2 2026, up 41.37Mn from the prior quarter and up 108.54Mn from a year earlier.
Artal Group S.A. was the top holder of Lexicon Pharmaceuticals as of June 30, 2026, with 175.16Mn shares, or 39.20% of shares outstanding.
Holders that added the most shares of Lexicon Pharmaceuticals in Q2 2026 were Artal Group S.A. (+20.42Mn shares), BlackRock, Inc. (+14.03Mn shares), FMR LLC (+6.73Mn shares), State Street Corp (+3.95Mn shares) and Geode Capital Management, LLC (+3.08Mn shares).
Among holders that kept a stake in Lexicon Pharmaceuticals, the biggest sellers in Q2 2026 were Millennium Management LLC (-3.81Mn shares), UBS Group AG (-1.8Mn shares), CIBC Bancorp USA Inc. (-1.79Mn shares), Susquehanna International Group, LLP (-1.42Mn shares) and Goldman Sachs Group Inc (-584.97K shares).
Business Quant data shows the 10 biggest positions in Lexicon Pharmaceuticals as of Q2 2026 were held by Artal Group S.A. (175.16Mn shares), FMR LLC (51.78Mn shares), Siren, L.L.C. (44.3Mn shares), Sessa Capital IM, L.P. (18.96Mn shares), BlackRock, Inc. (17.35Mn shares), Vanguard Capital Management LLC (9.9Mn shares), Point72 Asset Management, L.P. (8.25Mn shares), Geode Capital Management, LLC (6.24Mn shares), State Street Corp (4.92Mn shares) and Vanguard Portfolio Management LLC (2.36Mn shares).

Form 13F Holdings

150 Institutional Holders

Report period 30 Jun, 2026

Total shares held 364.75Mn

Of outstanding 81.62%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	Artal Group S.A.	0001053906	175,156,062	39.20%	▲20,421,735	+13.20%	$420.37Mn
2	FMR LLC	0000315066	51,782,045	11.59%	▲6,725,707	+14.93%	$124.28Mn
3	Siren, L.L.C.	0002005245	44,303,518	9.91%	0	0.00%	$106.33Mn
4	Sessa Capital IM, L.P.	0001595849	18,960,836	4.24%	▲1,047,875	+5.85%	$45.51Mn
5	BlackRock, Inc.	0002012383	17,348,741	3.88%	▲14,026,522	+422.20%	$41.64Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	9,901,208	2.22%	▲382,041	+4.01%	$23.76Mn
7	Point72 Asset Management, L.P.	0001603466	8,251,325	1.85%	▲436,719	+5.59%	$19.80Mn
8	GEODE CAPITAL MANAGEMENT, LLC	0001214717	6,244,372	1.40%	▲3,075,261	+97.04%	$14.99Mn
9	State Street Corp	0000093751	4,917,769	1.10%	▲3,953,731	+410.12%	$11.80Mn
10	VANGUARD PORTFOLIO MANAGEMENT LLC	0002100121	2,357,749	0.53%	▲1,811,149	+331.35%	$5.66Mn
11	Northern Trust Corp	0000073124	1,968,619	0.44%	▲1,473,953	+297.97%	$4.72Mn
12	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0000884546	1,956,775	0.44%	▲645,477	+49.22%	$4.70Mn
13	VANGUARD FIDUCIARY TRUST CO	0000933478	1,634,571	0.37%	▲302,287	+22.69%	$3.92Mn
14	CITADEL ADVISORS LLC	0001423053	1,601,182	0.36%	▲506,281	+46.24%	$3.84Mn
15	Ishara Investments LP	0002111609	1,271,000	0.28%	▲369,000	+40.91%	$3.05Mn
16	MILLENNIUM MANAGEMENT LLC	0001273087	1,134,229	0.25%	▼3,810,502	-77.06%	$2.72Mn
17	RENAISSANCE TECHNOLOGIES LLC	0001037389	1,127,000	0.25%	▼473,500	-29.58%	$2.70Mn
18	MACKENZIE FINANCIAL CORP	0000919859	963,354	0.22%	▲190,677	+24.68%	$2.31Mn
19	ADAR1 Capital Management, LLC	0001940272	750,000	0.17%	0	0.00%	$1.80Mn
20	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0001446194	696,776	0.16%	▼1,424,388	-67.15%	$1.67Mn

Showing 1 to 20 of 150 holders