Lexicon Pharmaceuticals LXRX Insider Ownership

NASDAQ LXRX

$1.58 +0.03 (+1.94%)

At close: Oct 20, 2026 · 4:00 PM EDT

Insider Holdings by Owner

327.41Mn Shares

Insider Ownership Statistics

as of 30 Sep, 2026

Insider Ownership

41.97%

▼-0.073% pp QoQ

Shares Held by Insiders

187.54Mn

filed for Sep 2026

▼-0.17% QoQ

Shares Outstanding

446.87Mn

446,870,629 shares

Direct Holdings

5.39Mn

Indirect: 182.15Mn

Net Shares Traded (QoQ)

-324.21K

net selling in Sep 2026

Insiders Holding Shares

with Form 4 holdings on file

Shares Owned by Insiders

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Insiders

Bought Sold

Latest quarter —

Net over range —

Buying quarters —

Insider Ownership Summary

Updated Oct 10, 2026

Over the trailing 12 months, LXRX insiders bought $2.72 million worth of shares (2.06Mn shares) in open-market trades, with no open-market sales.

By number of insiders, Lexicon Pharmaceuticals saw 2 insiders buy on the open market over the past 12 months and none sell.
Among Lexicon Pharmaceuticals insiders, Invus Global Management, LLC (Director and 10% owner) led open-market buying over the past 12 months with $2 million of purchases (1.54Mn shares); the latest was on February 2, 2026.
The latest open-market trade on record is a purchase of 2K shares for $2,980 by Raymond Debbane (Director) on February 25, 2026.
Outside the open market, Lexicon Pharmaceuticals insiders received 22.4Mn shares in stock awards, acquired 22.3Mn shares through option exercises and conversions and gave up 676.67K shares to cover taxes or exercise prices over the past 12 months.
Business Quant data puts insider holdings in LXRX at 187.54Mn shares across insiders' latest Form 4 filings, or 41.97% of the 446.87Mn shares outstanding; that total is down 0.17% from 187.86Mn shares at the end of Q2 2026 and up 1.24% from 185.24Mn shares at the end of Q3 2025.
Direct holdings account for 5.39Mn shares (2.87%) of LXRX's insider total, and indirect holdings through trusts, partnerships and family members for 182.15Mn shares (97.13%).
The insider holdings in Lexicon Pharmaceuticals belong to 19 insiders who have reported on Form 4 within the past two years.
LXRX's three largest insider shareholders, per their latest Form 4 filings, are Artal Participations S.A R.L. (Director and 10% owner, 175.16Mn shares), Raymond Debbane (Director, 7.45Mn shares) and Invus Global Management, LLC (Director and 10% owner, 1.54Mn shares).
Of the shares held by LXRX insiders, 93.40% belong to Artal Participations S.A R.L.
A total of 37 Form 4 filings with transactions in Lexicon Pharmaceuticals stock were made over the past 12 months, by 17 insiders.
The insider holdings and trades above for Lexicon Pharmaceuticals reflect Form 4 filings through June 4, 2026.

Form 4 Holdings

Insiders Holding LXRX

Insiders 28

Shares held 327.41Mn

Of outstanding 73.27%

#	Insider	Position	Direct	Indirect	Total	Share of Insiders	Last Filed
1	Participations S.A R.L. Artal	Director, TenPercentOwner	0	175,564,497	175,564,497	53.6%	08 May, 2026
2	International S.C.A. Artal	Director, TenPercentOwner	0	137,331,403	137,331,403	41.9%	14 May, 2024
3	Us Partners Llc Invus	Director, TenPercentOwner	0	5,451,204	5,451,204	1.7%	09 Aug, 2022
4	Raymond Debbane	Director	1,995,498	0	1,995,498	0.6%	04 Jun, 2026
5	Global Management, Llc Invus	Director, TenPercentOwner	0	1,905,607	1,905,607	0.6%	04 Feb, 2026
6	Lonnel Coats	Chief Executive Officer	1,098,068	0	1,098,068	0.3%	29 Feb, 2024
7	Brian T Crum	Svp, General Counsel Secr.	428,802	0	428,802	0.1%	03 Mar, 2026
8	Philippe Amouyal	Director	374,486	0	374,486	0.1%	04 Jun, 2026
9	Alan J Main	Evp, Innov Chem Sciences	339,104	0	339,104	0.1%	03 Mar, 2025
10	Jeffrey L Wade	President And Cfo	324,214	0	324,214	0.1%	29 Feb, 2024
11	Craig B Granowitz	Svp, Chief Medical Officer	323,430	0	323,430	0.1%	03 Mar, 2026
12	Michael Exton	Chief Executive Officer	298,432	0	298,432	0.1%	03 Mar, 2026
13	Christopher J Sobecki	Director	293,177	0	293,177	0.1%	04 Jun, 2026
14	Wendy Mcdermott	Svp, Human Resources	277,945	0	277,945	0.1%	03 Mar, 2026
15	Sam L Barker	Director	213,771	0	213,771	0.1%	04 Jun, 2026
16	Judith L Swain	Director	174,486	0	174,486	0.1%	04 Jun, 2026
17	Kenneth B. Kassler-Taub	Svp, Regulatory Qa	162,672	0	162,672	0.0%	29 Feb, 2024
18	Suma Gopinathan	Svp, Discovery	150,132	0	150,132	0.0%	03 Mar, 2026
19	Diane E. Sullivan	Director	126,122	0	126,122	0.0%	04 Jun, 2026
20	Scott M Coiante	Svp, Chief Financial Officer	105,356	0	105,356	0.0%	03 Mar, 2026
21	Lisa Defrancesco	Svp, Ir And Corp Comm	93,869	0	93,869	0.0%	03 Mar, 2026
22	Ivan Cheung	Director	89,312	0	89,312	0.0%	04 Jun, 2026
23	Kristen Alexander	Vp, Finance And Accounting	76,368	0	76,368	0.0%	03 Mar, 2025
24	Kiernan Seth	Vp, Chief Commercial Officer	53,136	0	53,136	0.0%	01 Mar, 2023
25	Robert J Md Lefkowitz	Director	48,364	0	48,364	0.0%	29 Apr, 2024
26	Alan S Nies	Director	41,046	0	41,046	0.0%	22 May, 2023
27	Frank Palantoni	Director	40,332	0	40,332	0.0%	22 May, 2023
28	Rachel Yap Martens	Svp, Partnerships Corp Strat	31,264	0	31,264	0.0%	03 Mar, 2026

Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.

Form 4 Filings

1,667 Insider Transactions

Source SEC Form 4

Latest quarter Sep 2026

Date	Insider	Position	Transaction	Shares	Price	Value	Shares Held After	Ownership
03 Jun, 2026	Philippe Amouyal	Director	Acquired M	89,312	$0.00	$0	374,486	Direct
03 Jun, 2026	Raymond Debbane	Director	Acquired M	89,312	$0.00	$0	1,995,498	Direct
03 Jun, 2026	Ivan Cheung	Director	Acquired M	89,312	$0.00	$0	89,312	Direct
03 Jun, 2026	Judith L Swain	Director	Acquired M	89,312	$0.00	$0	174,486	Direct
03 Jun, 2026	Diane E. Sullivan	Director	Acquired M	89,312	$0.00	$0	126,122	Direct
03 Jun, 2026	Sam L Barker	Director	Acquired M	89,312	$0.00	$0	213,771	Direct
03 Jun, 2026	Christopher J Sobecki	Director	Acquired M	89,312	$0.00	$0	293,177	Direct
03 Jun, 2026	Judith L Swain	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Ivan Cheung	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Diane E. Sullivan	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Sam L Barker	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Christopher J Sobecki	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Philippe Amouyal	Director	Disposed M	89,312	$0.00	$0	0	Direct
03 Jun, 2026	Raymond Debbane	Director	Disposed M	89,312	$0.00	$0	0	Direct
30 Apr, 2026	Participations S.A R.L. Artal	Director, TenPercentOwner	Acquired M	20,421,735	$0.00	$0	175,156,062	Indirect
30 Apr, 2026	Participations S.A R.L. Artal	Director, TenPercentOwner	Acquired A	408,435	—	—	408,435	Indirect
30 Apr, 2026	Participations S.A R.L. Artal	Director, TenPercentOwner	Disposed M	408,435	$0.00	$0	0	Indirect
01 May, 2026	Ivan Cheung	Director	Acquired A	35,714	$0.00	$0	35,714	Direct
01 May, 2026	Raymond Debbane	Director	Acquired A	35,714	$0.00	$0	35,714	Direct
01 May, 2026	Diane E. Sullivan	Director	Acquired A	35,714	$0.00	$0	35,714	Direct

Showing 1 to 20 of 1,667 transactions