Amylyx Pharmaceuticals AMLX Institutional Ownership

NASDAQ AMLX

$29.03 +0.26 (+0.90%)

At close: Oct 21, 2026 · 4:00 PM EDT

Institutions by Trading Activity

205 Institutions

Increased 121 59.0%

Unchanged 24 11.7%

Reduced 60 29.3%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

—

13F totals exceed reported shares outstanding

Shares Held by Institutions

114.97Mn

of 111.37Mn outstanding

▲+0.72% QoQ

Shares Outstanding

111.37Mn

Institutional Investors

205

filed 13F for Jun 2026

▲+34 vs prior quarter

Net Shares Added (QoQ)

+816.44K

accumulated since last quarter

Value of Holdings

$3.31Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 11, 2026

Amylyx Pharmaceuticals, Inc. (NASDAQ:AMLX) had 205 institutional holders reporting a position on Form 13F for the quarter ended June 30, 2026.

Total shares held in Amylyx Pharmaceuticals rose 0.72% from Q1 2026, while the number of holders rose 61.42% from Q2 2025.
Of the 205 holders of AMLX in Q2 2026, 121 added to their positions, 60 reduced their stakes and 24 left their positions unchanged.
Altogether, institutional holders owned 114.97Mn AMLX shares at the end of Q2 2026, up 816.44K from the prior quarter and up 35.23Mn from a year earlier.
FMR LLC was the top holder of Amylyx Pharmaceuticals as of June 30, 2026, with 16.73Mn shares.
Holders that added the most shares of Amylyx Pharmaceuticals in Q2 2026 were JPMorgan Chase & Co (+1.7Mn shares), Morgan Stanley (+955.26K shares), Franklin Templeton Inc (+688.66K shares), Two Sigma Investments, LP (+431.49K shares) and Saturn V Capital Management LP (+274.22K shares).
Holders that trimmed the most shares of Amylyx Pharmaceuticals in Q2 2026 while keeping a position were Adage Capital Partners GP, L.L.C. (-1.66Mn shares), Almitas Capital LLC (-1.15Mn shares), Great Point Partners LLC (-1.05Mn shares), Barclays PLC (-915.6K shares) and Deutsche Bank AG (-709.85K shares).
Per Business Quant data, the 10 largest holders of Amylyx Pharmaceuticals at the end of Q2 2026 were FMR LLC (16.73Mn shares), BlackRock, Inc. (8.83Mn shares), Perceptive Advisors LLC (8.33Mn shares), TCG Crossover Management, LLC (6.24Mn shares), Commodore Capital LP (5.65Mn shares), Jupiter Topco LLC (5.24Mn shares), Saturn V Capital Management LP (4.62Mn shares), Vanguard Capital Management LLC (4.22Mn shares), Morgan Stanley (3.13Mn shares) and Driehaus Capital Management LLC (3.04Mn shares).

Form 13F Holdings

205 Institutional Holders

Report period 30 Jun, 2026

Total shares held 114.97Mn

Of outstanding —

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	FMR LLC	0000315066	16,727,909	15.02%	▲97,368	+0.59%	$300.43Mn
2	BlackRock, Inc.	0002012383	8,827,085	7.93%	▼1,751	-0.02%	$158.53Mn
3	PERCEPTIVE ADVISORS LLC	0001224962	8,334,882	7.48%	▲50,000	+0.60%	$149.69Mn
4	TCG Crossover Management, LLC	0001839948	6,243,812	5.61%	0	0.00%	$112.14Mn
5	Commodore Capital LP	0001831942	5,650,000	5.07%	0	0.00%	$101.47Mn
6	Jupiter Topco LLC	0002146052	5,236,102	4.70%	▲5,236,102	0.00%	$94.01Mn
7	Saturn V Capital Management LP	0001964437	4,624,101	4.15%	▲274,216	+6.30%	$83.05Mn
8	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	4,224,224	3.79%	▲82,649	+2.00%	$75.87Mn
9	Morgan Stanley	0000895421	3,130,808	2.81%	▲955,261	+43.91%	$56.23Mn
10	DRIEHAUS CAPITAL MANAGEMENT LLC	0000938206	3,036,970	2.73%	▲49,823	+1.67%	$54.54Mn
11	First Light Asset Management, LLC	0001600004	3,023,256	2.71%	▼167,389	-5.25%	$54.30Mn
12	Franklin Templeton Inc	0000038777	2,950,225	2.65%	▲688,656	+30.45%	$52.99Mn
13	Goldman Sachs Group Inc	0000886982	2,858,239	2.57%	▲232,248	+8.84%	$51.33Mn
14	State Street Corp	0000093751	2,603,337	2.34%	▲240,176	+10.16%	$46.76Mn
15	GEODE CAPITAL MANAGEMENT, LLC	0001214717	2,335,315	2.10%	▲124,383	+5.63%	$41.95Mn
16	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	1,900,000	1.71%	▼1,660,764	-46.64%	$34.12Mn
17	Jpmorgan Chase & Co	0000019617	1,863,650	1.67%	▲1,703,987	+1,067.24%	$34.92Mn
18	Siren, L.L.C.	0002005245	1,480,586	1.33%	▲250,586	+20.37%	$26.59Mn
19	EVENTIDE ASSET MANAGEMENT, LLC	0001442891	1,327,536	1.19%	▼186,422	-12.31%	$23.84Mn
20	683 Capital Management, LLC	0001404574	1,279,512	1.15%	▼250,488	-16.37%	$22.98Mn

Showing 1 to 20 of 205 holders