Zymeworks (ZYME) Operating Margin (2021 - 2026)
Zymeworks (ZYME) recorded Operating Margin of -918.95% in Q2 2026, down 917.57 percentage points from -1.38% a year earlier but up 1037.77 percentage points from the prior quarter.
Powered by 
Analysis
Zymeworks (ZYME) Operating Margin (2021 - 2026) Analysis & Trends
On a TTM basis, Zymeworks' Operating Margin came in at -418.99% as of Jun 30, 2026, down 351.68 percentage points year-over-year; for FY2025, it came in at -87.34%, up 92.35 percentage points from FY2024.
- Annual Operating Margin has a five-year change of +393.95 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -179.69% in FY2024 (+1.93 pp), -181.62% in FY2023 (-213.26 pp), 31.64% in FY2022 (+839.86 pp) and -808.22% in FY2021 (-326.93 pp).
- Quarterly Operating Margin has ranged from -3793.63% in Q1 2022 to 79.35% in Q4 2022 over the past five years.
- On a year-over-year basis, Operating Margin has declined for three consecutive quarters, with an average year-over-year change of -471.48 percentage points over the last eight quarters.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 3716.95 percentage points in Q1 2023, against a drop of 1862.25 percentage points in Q1 2026 at the low end.
- Per Business Quant, the preceding three quarters came in at -1956.73% (Q1 2026), -1755.55% (Q4 2025) and -80.07% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,131.65 Bn | 1,100.24 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 615.89 Bn | 534.41 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 505.03 Bn | 478.14 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 368.78 Bn | 323.16 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 298.66 Bn | 262.65 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 262.09 Bn | 235.78 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 236.57 Bn | 191.97 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 191.05 Bn | 165.25 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 170.60 Bn | 117.25 Bn | 10.94 Bn | 28.37% |
| 10 | Zymeworks | 2.04 Bn | 923.28 Mn | - | -918.95% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -918.95% |
| Mar 31, 2026 | -1,956.73% |
| Dec 31, 2025 | -1,755.55% |
| Sep 30, 2025 | -80.07% |
| Jun 30, 2025 | -1.38% |
| Mar 31, 2025 | -94.48% |
| Dec 31, 2024 | -71.60% |
| Sep 30, 2024 | -213.78% |
| Jun 30, 2024 | -222.87% |
| Mar 31, 2024 | -376.89% |
| Dec 31, 2023 | -138.37% |
| Sep 30, 2023 | -201.36% |
| Jun 30, 2023 | -772.84% |
| Mar 31, 2023 | -76.68% |
| Dec 31, 2022 | 79.35% |
| Sep 30, 2022 | -1,914.03% |
| Jun 30, 2022 | -1,209.54% |
| Mar 31, 2022 | -3,793.63% |
| Dec 31, 2021 | -205.58% |
| Sep 30, 2021 | -1,387.12% |
API Access
Zymeworks Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=ZYME&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "ZYME", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=ZYME&period=max&api_key=YOUR_API_KEY");
const data = await res.json();