Zymeworks (ZYME) Operating Margin (2021 - 2026)
Zymeworks (ZYME) posted Operating Margin of 1956.73% for Q1 2026, down 11.46% sequentially from 1755.55% in Q4 2025, and down 186225.0% YoY from N/an in Q1 2025.
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Zymeworks (ZYME) Operating Margin (2021 - 2026) Analysis & Trends
Zymeworks has reported Operating Margin for 6 years, with the latest figure at 1956.73% in Q1 2026.
- Quarterly Operating Margin fell 186225.0% year-over-year to 1956.73% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 140.35% (down 658.0% YoY) and the FY2025 annual result came in at 87.34%, up 9235.0% from the prior year.
- Operating Margin slipped to 1956.73% in Q1 2026 per ZYME's latest filing, from 1755.55% in the prior quarter.
- Over five years, Operating Margin peaked at 98.28% in Q4 2022 and troughed at 3793.63% in Q1 2022.
- A 5-year average of 751.85% and a median of 213.78% in 2024 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2023 and 2026: Operating Margin soared 371695 bps in 2023, then tumbled 186225 bps in 2026.
- Over 5 years, Operating Margin stood at 98.28% in 2022, then sank by 241 bps to 138.37% in 2023, then surged by 48 bps to 71.6% in 2024, then tumbled by 2352 bps to 1755.55% in 2025, then decreased by 11 bps to 1956.73% in 2026.
- According to Business Quant data, Operating Margin over the past three periods registered 1956.73%, 1755.55%, and 80.07% for Q1 2026, Q4 2025, and Q3 2025 respectively.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -562.07% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 19.06% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 17.93% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 19.75% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -0.36% |
| 10 | Zymeworks | 2.13 Bn | 1.86 Bn | - | -918.95% |
Historic Data
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Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -918.95% |
| Mar 31, 2026 | -1,956.73% |
| Dec 31, 2025 | -1,755.55% |
| Sep 30, 2025 | -80.07% |
| Jun 30, 2025 | -1.38% |
| Mar 31, 2025 | -94.48% |
| Dec 31, 2024 | -71.60% |
| Sep 30, 2024 | -213.78% |
| Jun 30, 2024 | -222.87% |
| Mar 31, 2024 | -376.89% |
| Dec 31, 2023 | -138.37% |
| Sep 30, 2023 | -201.36% |
| Jun 30, 2023 | -772.84% |
| Mar 31, 2023 | -76.68% |
| Dec 31, 2022 | 98.28% |
| Sep 30, 2022 | -1,914.03% |
| Jun 30, 2022 | -1,209.54% |
| Mar 31, 2022 | -3,793.63% |
| Dec 31, 2021 | -510.61% |
| Sep 30, 2021 | -1,387.12% |