Zymeworks (ZYME) Operating Margin (2021 - 2026)

Zymeworks has disclosed Operating Margin across 6 years of filings, most recently posting 1956.73% for Q1 2026.

• Operating Margin for Q1 2026 came in at 1956.73%, down 113050.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 145.02% (up 6988.0% YoY), and the FY2025 annual result was 87.34%, up 9235.0% from the prior year.
• Operating Margin came in at 1956.73% for Q1 2026 at Zymeworks, down from 1755.55% in the prior quarter.
• In the past five years, Operating Margin ranged from a high of 98.28% in Q4 2022 to a low of 3793.63% in Q1 2022.
• The 5-year median for Operating Margin is 376.89% (2024), against an average of 813.81%.
• Across the five-year window, Operating Margin jumped 371695 bps in 2023 and slumped 168395 bps in 2025, its largest moves.
• Zymeworks' Operating Margin stood at 98.28% in 2022, then sank by 241 bps to 138.37% in 2023, then soared by 48 bps to 71.6% in 2024, then tumbled by 2352 bps to 1755.55% in 2025, then fell by 11 bps to 1956.73% in 2026.
• The last three Operating Margin figures came in at 1956.73% (Q1 2026), 1755.55% (Q4 2025), and 88.44% (Q3 2025), per Business Quant data.