Xencor (XNCR) Operating Margin (2013 - 2026)
Xencor (XNCR) reported Operating Margin of 1724.14% for Q1 2026, down 159221.0% year-over-year from N/an in Q1 2025, and down 807.82% quarter-over-quarter from 189.92% in Q4 2025.
Xencor (XNCR) Operating Margin (2013 - 2026) Analysis & Trends
Xencor (XNCR) has 14 years of Operating Margin data on file, last reported at 1724.14% in Q1 2026.
- Operating Margin for Q1 2026 came in at 1724.14%, down 159221.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 217.93% (down 8673.0% YoY), and the FY2025 annual result was 141.35%, up 2012.0% from the prior year.
- Operating Margin fell to 1724.14% in Q1 2026 per XNCR's latest filing, from 189.92% in the prior quarter.
- Over five years, Operating Margin peaked at 30.96% in Q1 2022 and troughed at 1724.14% in Q1 2026.
- A 5-year average of 242.24% and a median of 140.47% in 2022 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2025 and 2026: Operating Margin jumped 20978 bps in 2025, then tumbled 159221 bps in 2026.
- A 5-year view of Operating Margin shows it stood at 197.19% in 2022, then soared by 73 bps to 53.61% in 2023, then jumped by 53 bps to 24.96% in 2024, then plunged by 661 bps to 189.92% in 2025, then plunged by 808 bps to 1724.14% in 2026.
- Business Quant data shows XNCR's Operating Margin at 1724.14% in Q1 2026, 189.92% in Q4 2025, and 226.29% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Xencor | 953.38 Mn | 878.64 Mn | - | -1,724.14% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -1,724.14% |
| Dec 31, 2025 | -189.92% |
| Sep 30, 2025 | -226.29% |
| Jun 30, 2025 | -76.07% |
| Mar 31, 2025 | -131.93% |
| Dec 31, 2024 | -24.96% |
| Sep 30, 2024 | -310.17% |
| Jun 30, 2024 | -231.61% |
| Mar 31, 2024 | -341.71% |
| Dec 31, 2023 | -53.61% |
| Sep 30, 2023 | -30.88% |
| Jun 30, 2023 | -57.11% |
| Mar 31, 2023 | -320.35% |
| Dec 31, 2022 | -197.19% |
| Sep 30, 2022 | -140.47% |
| Jun 30, 2022 | -92.72% |
| Mar 31, 2022 | 30.96% |
| Dec 31, 2021 | 59.51% |
| Sep 30, 2021 | -209.83% |
| Jun 30, 2021 | 13.47% |