Xeris Biopharma Holdings (XERS) Operating Margin (2020 - 2026)
Xeris Biopharma Holdings (XERS) recorded Operating Margin of 5.62% in Q2 2026, down 0.65 percentage points from 6.27% a year earlier and down 3.91 percentage points from the prior quarter.
Powered by 
Analysis
Xeris Biopharma Holdings (XERS) Operating Margin (2020 - 2026) Analysis & Trends
On a TTM basis, Xeris Biopharma Holdings' Operating Margin came in at 10.91% as of Jun 30, 2026, up 14.90 percentage points year-over-year; for FY2025, it came in at 8.53%, up 25.10 percentage points from FY2024.
- Annual Operating Margin has increased for five straight years, with a five-year change of +417.37 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -16.57% in FY2024 (+10.28 pp), -26.85% in FY2023 (+47.47 pp), -74.32% in FY2022 (+157.89 pp) and -232.22% in FY2021 (+176.62 pp).
- The Q2 2026 figure is the lowest quarterly Operating Margin since Q1 2025.
- On a year-over-year basis, Operating Margin rose in six of the last eight quarters, with an average year-over-year change of +16.02 percentage points.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 214.80 percentage points in Q2 2022, against a drop of 74.08 percentage points in Q3 2021 at the low end.
- Per Business Quant, the preceding three quarters came in at 9.52% (Q1 2026), 19.55% (Q4 2025) and 9.05% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Xeris Biopharma Holdings | 1.71 Bn | 1.27 Bn | 79.59 Mn | 5.62% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 5.62% |
| Mar 31, 2026 | 9.52% |
| Dec 31, 2025 | 19.55% |
| Sep 30, 2025 | 9.05% |
| Jun 30, 2025 | 6.27% |
| Mar 31, 2025 | -5.14% |
| Dec 31, 2024 | 2.79% |
| Sep 30, 2024 | -23.76% |
| Jun 30, 2024 | -17.03% |
| Mar 31, 2024 | -35.05% |
| Dec 31, 2023 | -22.17% |
| Sep 30, 2023 | -10.17% |
| Jun 30, 2023 | -42.04% |
| Mar 31, 2023 | -40.00% |
| Dec 31, 2022 | -45.77% |
| Sep 30, 2022 | -63.18% |
| Jun 30, 2022 | -74.75% |
| Mar 31, 2022 | -131.72% |
| Dec 31, 2021 | -225.26% |
| Sep 30, 2021 | -220.24% |
API Access
Xeris Biopharma Holdings Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=XERS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "XERS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=XERS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();