Sarepta Therapeutics (SRPT) Operating Margin (2010 - 2026)
Sarepta Therapeutics (SRPT) posted quarterly Operating Margin of 49.05% for Q1 2026, up 27434.0% year-over-year from N/an in Q1 2025, and up 152.78% quarter-over-quarter from 92.92% in Q4 2025.
Sarepta Therapeutics (SRPT) Operating Margin (2010 - 2026) Analysis & Trends
Sarepta Therapeutics' Operating Margin history runs 15 years deep, the most recent figure standing at 49.05% for Q1 2026.
- In Q1 2026, Operating Margin rose 27434.0% year-over-year to 49.05%; the TTM figure through Mar 2026 stood at 1.88% (up 535.0% YoY), while the FY2025 annual figure was 37.54%, down 4900.0% from the prior year.
- Operating Margin for Q1 2026 stood at 49.05%, up from 92.92% in the prior quarter.
- The five-year high for Operating Margin was 49.05% in Q1 2026, with the low at 225.29% in Q1 2025.
- The 5-year median for Operating Margin is 12.33% (2022), against an average of 33.48%.
- The sharpest annual moves came in 2025 and 2026: Operating Margin plunged 23373 bps in 2025, then soared 27434 bps in 2026.
- Sarepta Therapeutics' Operating Margin stood at 12.33% in 2022, then soared by 119 bps to 2.28% in 2023, then surged by 975 bps to 24.56% in 2024, then plunged by 478 bps to 92.92% in 2025, then soared by 153 bps to 49.05% in 2026.
- Business Quant data shows SRPT's Operating Margin at 49.05% in Q1 2026, 92.92% in Q4 2025, and 25.89% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 128.13 Bn | 120.28 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 112.33 Bn | 104.33 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 53.24 Bn | 48.05 Bn | 1.41 Bn | 31.68% |
| 4 | Revolution Medicines | 43.64 Bn | 43.64 Bn | - | - |
| 5 | BeOne Medicines | 39.27 Bn | 34.17 Bn | 1.53 Bn | 19.06% |
| 6 | MindWalk Holdings | 35.32 Bn | 35.31 Bn | 1.82 Bn | -105.20% |
| 7 | Royalty Pharma | 33.72 Bn | 35.84 Bn | - | 19.75% |
| 8 | Alnylam Pharmaceuticals | 30.58 Bn | 27.27 Bn | 992.69 Mn | 17.93% |
| 9 | Insmed | 27.01 Bn | 25.85 Bn | 358.27 Mn | -0.36% |
| 10 | Sarepta Therapeutics | 1.91 Bn | 1.12 Bn | 251.87 Mn | 3.31% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | 3.31% |
| Mar 31, 2026 | 49.05% |
| Dec 31, 2025 | -92.92% |
| Sep 30, 2025 | -25.89% |
| Jun 30, 2025 | 18.91% |
| Mar 31, 2025 | -225.29% |
| Dec 31, 2024 | 24.56% |
| Sep 30, 2024 | 4.75% |
| Jun 30, 2024 | -0.19% |
| Mar 31, 2024 | 8.44% |
| Dec 31, 2023 | 2.28% |
| Sep 30, 2023 | -6.74% |
| Jun 30, 2023 | -51.11% |
| Mar 31, 2023 | -59.65% |
| Dec 31, 2022 | -12.33% |
| Sep 30, 2022 | -57.04% |
| Jun 30, 2022 | -99.95% |
| Mar 31, 2022 | -46.02% |
| Dec 31, 2021 | -59.20% |
| Sep 30, 2021 | -153.18% |