Regenxbio (RGNX) Operating Margin (2014 - 2025)
Regenxbio's (RGNX) quarterly Operating Margin came in at 212.3% in Q4 2025, up 2984.0% year-on-year from 6.88% in Q4 2024, and down 20.44% quarter-over-quarter from 176.27% in Q3 2025.
Regenxbio (RGNX) Operating Margin (2014 - 2025) Analysis & Trends
Regenxbio's Operating Margin history runs 12 years deep, the most recent figure standing at 212.3% for Q4 2025.
- On a quarterly basis, Operating Margin rose 2984.0% year-over-year to 212.3% in Q4 2025; TTM through Dec 2025 was 97.52%, a 18497.0% increase from a year earlier, with the FY2025 full-year figure at 103.16%, up 17688.0% from the prior year.
- Operating Margin fell to 212.3% in Q4 2025 per RGNX's latest filing, from 176.27% in the prior quarter.
- Across five years, Operating Margin topped out at 78.66% in Q4 2021 and bottomed at 416.21% in Q1 2024.
- The 5-year median for Operating Margin is 239.58% (2021), against an average of 230.5%.
- Across the five-year window, Operating Margin sank 26297 bps in 2022 and surged 43014 bps in 2025, its largest moves.
- Year by year, Operating Margin stood at 78.66% in 2021, then plunged by 334 bps to 184.31% in 2022, then slumped by 56 bps to 287.68% in 2023, then increased by 16 bps to 242.14% in 2024, then gained by 12 bps to 212.3% in 2025.
- Per Business Quant, the three latest RGNX Operating Margin figures stand at 212.3% (Q4 2025), 176.27% (Q3 2025), and 296.26% (Q2 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 16.51% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 38.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 17.83% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 31.68% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Regenxbio | 528.62 Mn | 298.55 Mn | 21.22 Mn | -212.30% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -212.30% |
| Sep 30, 2025 | -176.27% |
| Jun 30, 2025 | -296.26% |
| Mar 31, 2025 | 13.93% |
| Dec 31, 2024 | -242.14% |
| Sep 30, 2024 | -256.55% |
| Jun 30, 2024 | -256.51% |
| Mar 31, 2024 | -416.21% |
| Dec 31, 2023 | -287.68% |
| Sep 30, 2023 | -224.67% |
| Jun 30, 2023 | -365.96% |
| Mar 31, 2023 | -345.68% |
| Dec 31, 2022 | -184.31% |
| Sep 30, 2022 | -267.97% |
| Jun 30, 2022 | -191.53% |
| Mar 31, 2022 | -321.93% |
| Dec 31, 2021 | 78.66% |
| Sep 30, 2021 | -186.36% |
| Jun 30, 2021 | -237.01% |
| Mar 31, 2021 | -233.22% |