Ultragenyx Pharmaceutical (RARE) Operating Margin (2016 - 2026)
Ultragenyx Pharmaceutical (RARE) reported Operating Margin of 124.26% for Q1 2026, down 2139.0% year-over-year from 6.09% in Q1 2025, and down 127.37% quarter-over-quarter from 54.65% in Q4 2025.
Ultragenyx Pharmaceutical (RARE) Operating Margin (2016 - 2026) Analysis & Trends
Ultragenyx Pharmaceutical (RARE) has 11 years of Operating Margin data on file, last reported at 124.26% in Q1 2026.
- Operating Margin for Q1 2026 came in at 124.26%, down 2139.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 83.78% (up 326.0% YoY), and the FY2025 annual result was 79.49%, up 1622.0% from the prior year.
- Operating Margin declined to 124.26% in Q1 2026 per RARE's latest filing, from 54.65% in the prior quarter.
- Over five years, Operating Margin peaked at 54.65% in Q4 2025 and troughed at 248.14% in Q3 2022.
- A 5-year average of 123.86% and a median of 124.26% in 2026 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2022 and 2023: Operating Margin plunged 13812 bps in 2022, then jumped 10016 bps in 2023.
- A 5-year view of Operating Margin shows it stood at 140.91% in 2022, then soared by 32 bps to 95.83% in 2023, then increased by 22 bps to 74.28% in 2024, then gained by 26 bps to 54.65% in 2025, then slumped by 127 bps to 124.26% in 2026.
- Business Quant data shows RARE's Operating Margin at 124.26% in Q1 2026, 54.65% in Q4 2025, and 106.85% in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Ultragenyx Pharmaceutical | 2.77 Bn | 2.36 Bn | 106.00 Mn | -124.26% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -124.26% |
| Dec 31, 2025 | -54.65% |
| Sep 30, 2025 | -106.85% |
| Jun 30, 2025 | -64.80% |
| Mar 31, 2025 | -102.88% |
| Dec 31, 2024 | -74.28% |
| Sep 30, 2024 | -94.62% |
| Jun 30, 2024 | -79.14% |
| Mar 31, 2024 | -151.93% |
| Dec 31, 2023 | -95.83% |
| Sep 30, 2023 | -147.98% |
| Jun 30, 2023 | -136.61% |
| Mar 31, 2023 | -153.34% |
| Dec 31, 2022 | -140.91% |
| Sep 30, 2022 | -248.14% |
| Jun 30, 2022 | -158.48% |
| Mar 31, 2022 | -170.93% |
| Dec 31, 2021 | -122.99% |
| Sep 30, 2021 | -110.02% |
| Jun 30, 2021 | -95.17% |