Ultragenyx Pharmaceutical (RARE) Operating Margin (2016 - 2026)
Ultragenyx Pharmaceutical (RARE) posted quarterly Operating Margin of 124.26% for Q1 2026, down 2139.0% year-over-year from 6.09% in Q1 2025, and down 127.37% quarter-over-quarter from 54.65% in Q4 2025.
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Ultragenyx Pharmaceutical (RARE) Operating Margin (2016 - 2026) Analysis & Trends
Ultragenyx Pharmaceutical (RARE) has reported Operating Margin for 11 consecutive years, with 124.26% the latest figure, recorded in Q1 2026.
- In Q1 2026, Operating Margin fell 2139.0% year-over-year to 124.26%; the TTM figure through Mar 2026 stood at 83.78% (up 326.0% YoY), while the FY2025 annual figure was 79.49%, up 1622.0% from the prior year.
- Operating Margin slipped to 124.26% in Q1 2026 per RARE's latest filing, from 54.65% in the prior quarter.
- Across five years, Operating Margin topped out at 54.65% in Q4 2025 and bottomed at 248.14% in Q3 2022.
- Historically, Operating Margin has averaged 123.86% across 5 years, with a median of 124.26% in 2026.
- Annual changes were most pronounced in 2022 — Operating Margin plunged 13812 bps — and 2023, when it jumped 10016 bps.
- Ultragenyx Pharmaceutical's Operating Margin stood at 140.91% in 2022, then jumped by 32 bps to 95.83% in 2023, then rose by 22 bps to 74.28% in 2024, then advanced by 26 bps to 54.65% in 2025, then tumbled by 127 bps to 124.26% in 2026.
- Business Quant data shows RARE's Operating Margin at 124.26% in Q1 2026, 54.65% in Q4 2025, and 106.85% in Q3 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 138.47 Bn | 130.62 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 85.18 Bn | 77.19 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 63.38 Bn | 58.19 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 58.09 Bn | 52.95 Bn | 52.00 Mn | -562.07% |
| 5 | Revolution Medicines | 44.33 Bn | 44.33 Bn | - | - |
| 6 | BeOne Medicines | 40.02 Bn | 34.92 Bn | 1.53 Bn | 19.06% |
| 7 | Alnylam Pharmaceuticals | 35.57 Bn | 32.27 Bn | 992.69 Mn | 17.93% |
| 8 | Royalty Pharma | 28.45 Bn | 27.61 Bn | - | 19.75% |
| 9 | Insmed | 27.48 Bn | 26.32 Bn | 358.27 Mn | -0.36% |
| 10 | Ultragenyx Pharmaceutical | 1.56 Bn | 1.27 Bn | 180.00 Mn | -35.05% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -35.05% |
| Mar 31, 2026 | -124.26% |
| Dec 31, 2025 | -54.65% |
| Sep 30, 2025 | -106.85% |
| Jun 30, 2025 | -64.67% |
| Mar 31, 2025 | -102.88% |
| Dec 31, 2024 | -74.28% |
| Sep 30, 2024 | -94.62% |
| Jun 30, 2024 | -79.14% |
| Mar 31, 2024 | -151.93% |
| Dec 31, 2023 | -95.83% |
| Sep 30, 2023 | -147.98% |
| Jun 30, 2023 | -136.61% |
| Mar 31, 2023 | -153.34% |
| Dec 31, 2022 | -140.91% |
| Sep 30, 2022 | -248.14% |
| Jun 30, 2022 | -158.48% |
| Mar 31, 2022 | -170.93% |
| Dec 31, 2021 | -122.99% |
| Sep 30, 2021 | -110.02% |