Pyxis Oncology (PYXS) Operating Expenses (2020 - 2025)
Pyxis Oncology's (PYXS) quarterly Operating Expenses came in at $29.3 million in Q4 2025, down 26.79% year-on-year from $40.1 million in Q4 2024, and up 25.03% on a QoQ basis from $23.5 million in Q3 2025.
Pyxis Oncology (PYXS) Operating Expenses (2020 - 2025) Analysis & Trends
Pyxis Oncology (PYXS) has 6 years of Operating Expenses data on file, last reported at $29.3 million in Q4 2025.
- On a quarterly basis, Operating Expenses fell 26.79% year-over-year to $29.3 million in Q4 2025; TTM through Dec 2025 was $98.3 million, a 6.94% decrease from a year earlier, with the FY2025 full-year figure at $98.3 million, down 6.94% from the prior year.
- Operating Expenses for Q4 2025 stood at $29.3 million, up from $23.5 million in the prior quarter.
- Over the last five years, Operating Expenses for PYXS reached as high as $40.1 million in Q4 2024 and fell as low as $5.9 million in Q2 2021.
- Historically, Operating Expenses has averaged $24.0 million across 5 years, with a median of $23.2 million in 2025.
- Across the five-year window, Operating Expenses soared 333.02% in 2022 and slumped 53.21% in 2023, its largest moves.
- Year by year, Operating Expenses stood at $16.4 million in 2021, then jumped by 131.18% to $38.0 million in 2022, then slumped by 53.21% to $17.8 million in 2023, then jumped by 125.52% to $40.1 million in 2024, then retreated by 26.79% to $29.3 million in 2025.
- Per Business Quant data, the three most recent Operating Expenses figures were $29.3 million in Q4 2025, $23.5 million in Q3 2025, and $22.6 million in Q2 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -28.01 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 1.10 Bn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -3.78 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.85 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 2.96 Bn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | 32.68 Mn |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 2.89 Bn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | 445.22 Mn |
| 10 | Pyxis Oncology | 166.54 Mn | 99.69 Mn | 8.65 Mn | 29.33 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 29.33 Mn |
| Sep 30, 2025 | 23.46 Mn |
| Jun 30, 2025 | 22.57 Mn |
| Mar 31, 2025 | 22.91 Mn |
| Dec 31, 2024 | 40.07 Mn |
| Sep 30, 2024 | 23.75 Mn |
| Jun 30, 2024 | 20.03 Mn |
| Mar 31, 2024 | 21.75 Mn |
| Dec 31, 2023 | 17.77 Mn |
| Sep 30, 2023 | 25.35 Mn |
| Jun 30, 2023 | 18.12 Mn |
| Mar 31, 2023 | 20.95 Mn |
| Dec 31, 2022 | 37.97 Mn |
| Sep 30, 2022 | 28.39 Mn |
| Jun 30, 2022 | 25.73 Mn |
| Mar 31, 2022 | 31.39 Mn |
| Dec 31, 2021 | 16.43 Mn |
| Sep 30, 2021 | 11.62 Mn |
| Jun 30, 2021 | 5.94 Mn |
| Mar 31, 2021 | 35.73 Mn |