Pyxis Oncology (PYXS) Operating Expenses (2020 - 2025)

Pyxis Oncology's (PYXS) quarterly Operating Expenses came in at $29.3 million in Q4 2025, down 26.79% year-on-year from $40.1 million in Q4 2024, and up 25.03% on a QoQ basis from $23.5 million in Q3 2025.

Pyxis Oncology (PYXS) Operating Expenses (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Operating Expenses data on file, last reported at $29.3 million in Q4 2025.

  • On a quarterly basis, Operating Expenses fell 26.79% year-over-year to $29.3 million in Q4 2025; TTM through Dec 2025 was $98.3 million, a 6.94% decrease from a year earlier, with the FY2025 full-year figure at $98.3 million, down 6.94% from the prior year.
  • Operating Expenses for Q4 2025 stood at $29.3 million, up from $23.5 million in the prior quarter.
  • Over the last five years, Operating Expenses for PYXS reached as high as $40.1 million in Q4 2024 and fell as low as $5.9 million in Q2 2021.
  • Historically, Operating Expenses has averaged $24.0 million across 5 years, with a median of $23.2 million in 2025.
  • Across the five-year window, Operating Expenses soared 333.02% in 2022 and slumped 53.21% in 2023, its largest moves.
  • Year by year, Operating Expenses stood at $16.4 million in 2021, then jumped by 131.18% to $38.0 million in 2022, then slumped by 53.21% to $17.8 million in 2023, then jumped by 125.52% to $40.1 million in 2024, then retreated by 26.79% to $29.3 million in 2025.
  • Per Business Quant data, the three most recent Operating Expenses figures were $29.3 million in Q4 2025, $23.5 million in Q3 2025, and $22.6 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -28.01 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 1.10 Bn
4 NuCana 279.75 Bn 279.75 Bn - -3.78 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.85 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 2.96 Bn
7 Belite Bio 62.51 Bn 62.51 Bn - 32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 2.89 Bn
9 Revolution Medicines 37.78 Bn 37.78 Bn - 445.22 Mn
10 Pyxis Oncology 166.54 Mn 99.69 Mn 8.65 Mn 29.33 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 29.33 Mn
Sep 30, 2025 23.46 Mn
Jun 30, 2025 22.57 Mn
Mar 31, 2025 22.91 Mn
Dec 31, 2024 40.07 Mn
Sep 30, 2024 23.75 Mn
Jun 30, 2024 20.03 Mn
Mar 31, 2024 21.75 Mn
Dec 31, 2023 17.77 Mn
Sep 30, 2023 25.35 Mn
Jun 30, 2023 18.12 Mn
Mar 31, 2023 20.95 Mn
Dec 31, 2022 37.97 Mn
Sep 30, 2022 28.39 Mn
Jun 30, 2022 25.73 Mn
Mar 31, 2022 31.39 Mn
Dec 31, 2021 16.43 Mn
Sep 30, 2021 11.62 Mn
Jun 30, 2021 5.94 Mn
Mar 31, 2021 35.73 Mn