Protagonist Therapeutics (PTGX) Operating Margin (2017 - 2026)
Protagonist Therapeutics' Operating Margin was 74.37% in Q2 2026, up 832.41 percentage points from -758.04% a year earlier and up 80.84 percentage points from the prior quarter.
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Analysis
Protagonist Therapeutics (PTGX) Operating Margin (2017 - 2026) Analysis & Trends
On a trailing twelve-month basis, Protagonist Therapeutics' Operating Margin was 20.69% through Jun 30, 2026, up 9.23 percentage points year-over-year; for FY2025, it was -343.63%, down 401.84 percentage points from FY2024.
- Operating Margin shows a five-year change of -118.28 percentage points (FY2020 to FY2025).
- In earlier years, Operating Margin was 58.20% in FY2024 (+214.29 pp), -156.09% in FY2023 (+338.15 pp), -494.24% in FY2022 (-34.23 pp) and -460.01% in FY2021 (-234.65 pp).
- The Q2 2026 figure marks the highest quarterly Operating Margin since Q1 2024.
- Compared with a year earlier, Operating Margin was higher in four of the last seven quarters, with an average year-over-year change of +14.85 percentage points.
- The best year-over-year quarter for Operating Margin over five years was Q2 2026 (a gain of 832.41 percentage points); the worst was Q2 2022 (a drop of 3241.33 percentage points).
- Per Business Quant data, PTGX's Operating Margin in the three quarters before Q2 2026 was -6.47% (Q1 2026), -677.09% (Q4 2025) and -985.17% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Protagonist Therapeutics | 9.21 Bn | 9.21 Bn | - | 74.37% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 74.37% |
| Mar 31, 2026 | -6.47% |
| Dec 31, 2025 | -677.09% |
| Sep 30, 2025 | -985.17% |
| Jun 30, 2025 | -758.04% |
| Mar 31, 2025 | -68.18% |
| Dec 31, 2024 | 74.30% |
| Sep 30, 2024 | -886.70% |
| Jun 30, 2024 | -930.96% |
| Mar 31, 2024 | 80.92% |
| Dec 31, 2023 | 38.42% |
| Jun 30, 2022 | -4,604.78% |
| Mar 31, 2022 | -82.07% |
| Dec 31, 2021 | -429.57% |
| Sep 30, 2021 | -329.83% |
| Jun 30, 2021 | -1,363.44% |
| Mar 31, 2021 | -388.12% |
| Dec 31, 2020 | -333.27% |
| Sep 30, 2020 | -59.26% |
| Jun 30, 2020 | -293.02% |
API Access
Protagonist Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=PTGX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "PTGX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=PTGX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();