Mineralys Therapeutics (MLYS) Operating Margin (2022 - 2026)
Mineralys Therapeutics (MLYS) recorded Operating Margin of -4964.49% in Q2 2026, down 3618.89 percentage points from -1345.60% a year earlier and down 4208.32 percentage points from the prior quarter.
Mineralys Therapeutics (MLYS) Operating Margin (2022 - 2026) Analysis & Trends
On a TTM basis, Mineralys Therapeutics' Operating Margin came in at -1749.67% as of Jun 30, 2026, down 98.19 percentage points year-over-year; for FY2025, it was -1069.42%, up 249.50 percentage points from FY2024.
- Annual Operating Margin has a three-year change of +808.81 percentage points (FY2022 to FY2025).
- Across earlier years, Operating Margin came in at -1318.91% in FY2024 (-655.25 pp), -663.66% in FY2023 (+1214.56 pp) and -1878.22% in FY2022.
- The Q2 2026 figure is the lowest quarterly Operating Margin in data going back to Q3 2022.
- On a year-over-year basis, Operating Margin rose in three of the last eight quarters, with an average year-over-year change of -468.31 percentage points.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 1228.96 percentage points in Q1 2026, against a drop of 3618.89 percentage points in Q2 2026 at the low end.
- Per Business Quant, the preceding three quarters came in at -756.17% (Q1 2026), -633.25% (Q4 2025) and -980.48% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,264.65 Bn | 1,238.27 Bn | 20.46 Bn | 52.42% |
| 2 | Johnson & Johnson | 677.74 Bn | 597.60 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 517.10 Bn | 485.11 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 362.23 Bn | 325.17 Bn | 13.19 Bn | 30.89% |
| 5 | Novartis Ag | 315.90 Bn | 276.16 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 289.40 Bn | 266.24 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 249.90 Bn | 201.56 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 209.15 Bn | 184.26 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 165.88 Bn | 113.23 Bn | 12.56 Bn | 32.98% |
| 10 | Mineralys Therapeutics | 1.42 Bn | -1.17 Bn | - | - |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -4,964.49% |
| Mar 31, 2026 | -756.17% |
| Dec 31, 2025 | -633.25% |
| Sep 30, 2025 | -980.48% |
| Jun 30, 2025 | -1,345.60% |
| Mar 31, 2025 | -1,985.13% |
| Dec 31, 2024 | -1,842.90% |
| Sep 30, 2024 | -1,592.63% |
| Jun 30, 2024 | -1,087.86% |
| Mar 31, 2024 | -917.78% |
| Dec 31, 2023 | -834.42% |
| Sep 30, 2023 | -747.88% |
| Jun 30, 2023 | -437.93% |
| Mar 31, 2023 | -641.39% |
| Dec 31, 2022 | -1,070.37% |
| Sep 30, 2022 | -1,001.75% |
Mineralys Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=MLYS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "MLYS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=MLYS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();