Mirum Pharmaceuticals (MIRM) Operating Margin (2021 - 2026)
Mirum Pharmaceuticals (MIRM) recorded Operating Margin of -32.17% in Q3 2026, down 34.13 percentage points from 1.96% a year earlier and down 8.03 percentage points from the prior quarter.
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Analysis
Mirum Pharmaceuticals (MIRM) Operating Margin (2021 - 2026) Analysis & Trends
On a TTM basis, Mirum Pharmaceuticals' Operating Margin came in at -133.62% as of Sep 30, 2026, down 124.77 percentage points year-over-year; for FY2025, it came in at -4.25%, up 21.76 percentage points from FY2024.
- Annual Operating Margin has increased for four straight years, with a four-year change of +901.87 percentage points (FY2021 to FY2025).
- Across earlier years, Operating Margin came in at -26.00% in FY2024 (+32.56 pp), -58.57% in FY2023 (+111.71 pp), -170.28% in FY2022 (+735.84 pp) and -906.12% in FY2021.
- Quarterly Operating Margin has ranged from -1452.36% in Q4 2021 to 1.96% in Q3 2025 over the past five years.
- On a year-over-year basis, Operating Margin has declined for three consecutive quarters, with an average year-over-year change of -52.86 percentage points over the last eight quarters.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 1329.94 percentage points in Q4 2022, against a drop of 480.17 percentage points in Q1 2026 at the low end.
- Per Business Quant, the preceding three quarters came in at -24.14% (Q2 2026), -493.78% (Q1 2026) and -3.07% (Q4 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,264.65 Bn | 1,238.27 Bn | 20.46 Bn | 52.42% |
| 2 | Johnson & Johnson | 677.74 Bn | 597.60 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 517.10 Bn | 485.11 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 362.23 Bn | 325.17 Bn | 13.19 Bn | 30.89% |
| 5 | Novartis Ag | 315.90 Bn | 276.16 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 289.40 Bn | 266.24 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 249.90 Bn | 201.56 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 209.15 Bn | 184.26 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 165.88 Bn | 113.23 Bn | 12.56 Bn | 32.98% |
| 10 | Mirum Pharmaceuticals | 6.06 Bn | 4.48 Bn | 150.55 Mn | -32.17% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -32.17% |
| Jun 30, 2026 | -24.14% |
| Mar 31, 2026 | -493.78% |
| Dec 31, 2025 | -3.07% |
| Sep 30, 2025 | 1.96% |
| Jun 30, 2025 | -3.90% |
| Mar 31, 2025 | -13.61% |
| Dec 31, 2024 | -24.36% |
| Sep 30, 2024 | -14.03% |
| Jun 30, 2024 | -31.12% |
| Mar 31, 2024 | -38.24% |
| Dec 31, 2023 | -46.85% |
| Sep 30, 2023 | -52.69% |
| Jun 30, 2023 | -64.73% |
| Mar 31, 2023 | -85.92% |
| Dec 31, 2022 | -122.41% |
| Sep 30, 2022 | -175.09% |
| Jun 30, 2022 | -179.83% |
| Mar 31, 2022 | -253.92% |
| Dec 31, 2021 | -1,452.36% |
API Access
Mirum Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=MIRM&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "MIRM", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=MIRM&period=max&api_key=YOUR_API_KEY");
const data = await res.json();