Mirum Pharmaceuticals (MIRM) Operating Margin (2021 - 2026)
Mirum Pharmaceuticals (MIRM) recorded quarterly Operating Margin of 493.78% in Q1 2026, down 16002.39% quarter-over-quarter from 3.07% in Q4 2025, and down 48017.0% on a YoY basis from N/an in Q1 2025.
Mirum Pharmaceuticals (MIRM) Operating Margin (2021 - 2026) Analysis & Trends
Mirum Pharmaceuticals' Operating Margin history runs 6 years deep, the most recent figure standing at 493.78% for Q1 2026.
- In Q1 2026, Operating Margin fell 48017.0% year-over-year to 493.78%; the TTM figure through Mar 2026 stood at 139.82% (down 11969.0% YoY), while the FY2025 annual figure was 4.25%, up 2176.0% from the prior year.
- Operating Margin was 493.78% for Q1 2026 at Mirum Pharmaceuticals, down from 3.07% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 1.96% in Q3 2025 to a low of 493.78% in Q1 2026.
- Historically, Operating Margin has averaged 94.21% across 5 years, with a median of 46.85% in 2023.
- The sharpest annual moves came in 2022 and 2026: Operating Margin soared 132994 bps in 2022, then slumped 48017 bps in 2026.
- A 5-year view of Operating Margin shows it stood at 122.41% in 2022, then jumped by 62 bps to 46.85% in 2023, then soared by 48 bps to 24.36% in 2024, then soared by 87 bps to 3.07% in 2025, then slumped by 16002 bps to 493.78% in 2026.
- The last three Operating Margin figures came in at 493.78% (Q1 2026), 3.07% (Q4 2025), and 1.96% (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Mirum Pharmaceuticals | 6.29 Bn | 5.90 Bn | 131.08 Mn | -493.78% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -493.78% |
| Dec 31, 2025 | -3.07% |
| Sep 30, 2025 | 1.96% |
| Jun 30, 2025 | -3.90% |
| Mar 31, 2025 | -13.61% |
| Dec 31, 2024 | -24.36% |
| Sep 30, 2024 | -14.03% |
| Jun 30, 2024 | -31.12% |
| Mar 31, 2024 | -38.24% |
| Dec 31, 2023 | -46.85% |
| Sep 30, 2023 | -52.69% |
| Jun 30, 2023 | -64.73% |
| Mar 31, 2023 | -85.92% |
| Dec 31, 2022 | -122.41% |
| Sep 30, 2022 | -175.09% |
| Jun 30, 2022 | -179.83% |
| Mar 31, 2022 | -253.92% |
| Dec 31, 2021 | -1,452.36% |
| Sep 30, 2021 | -856.48% |
| Jun 30, 2021 | -340.01% |