Macrogenics (MGNX) Operating Margin (2012 - 2026)
Macrogenics (MGNX) reported Operating Margin of 160.96% for Q1 2026, up 16215.0% year-over-year from N/an in Q1 2025, and down 448.55% quarter-over-quarter from 29.34% in Q4 2025.
Macrogenics (MGNX) Operating Margin (2012 - 2026) Analysis & Trends
Macrogenics (MGNX) has 15 years of Operating Margin data on file, last reported at 160.96% in Q1 2026.
- Operating Margin for Q1 2026 came in at 160.96%, up 16215.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 40.53% (up 1895.0% YoY), and the FY2025 annual result was 48.72%, up 2501.0% from the prior year.
- Operating Margin declined to 160.96% in Q1 2026 per MGNX's latest filing, from 29.34% in the prior quarter.
- Over five years, Operating Margin peaked at 48.95% in Q3 2024 and troughed at 1763.06% in Q2 2024.
- A 5-year average of 305.6% and a median of 160.96% in 2026 frame the typical range for Operating Margin.
- The sharpest annual moves came in 2024 and 2025: Operating Margin sank 142078 bps in 2024, then jumped 159779 bps in 2025.
- A 5-year view of Operating Margin shows it stood at 16.39% in 2022, then sank by 2908 bps to 460.39% in 2023, then soared by 71 bps to 132.09% in 2024, then jumped by 78 bps to 29.34% in 2025, then sank by 449 bps to 160.96% in 2026.
- Business Quant data shows MGNX's Operating Margin at 160.96% in Q1 2026, 29.34% in Q4 2025, and 25.59% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | - |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -6.43% |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | - |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | - |
| 10 | Macrogenics | 260.14 Mn | 193.63 Mn | - | -160.96% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -160.96% |
| Dec 31, 2025 | -29.34% |
| Sep 30, 2025 | 25.59% |
| Jun 30, 2025 | -165.27% |
| Mar 31, 2025 | -323.10% |
| Dec 31, 2024 | -132.09% |
| Sep 30, 2024 | 48.95% |
| Jun 30, 2024 | -1,763.06% |
| Mar 31, 2024 | -590.40% |
| Dec 31, 2023 | -460.39% |
| Sep 30, 2023 | -341.46% |
| Jun 30, 2023 | -342.28% |
| Mar 31, 2023 | -156.87% |
| Dec 31, 2022 | 16.39% |
| Sep 30, 2022 | -59.80% |
| Jun 30, 2022 | -160.76% |
| Mar 31, 2022 | -600.29% |
| Dec 31, 2021 | -411.65% |
| Sep 30, 2021 | -338.32% |
| Jun 30, 2021 | -130.96% |