Lexicon Pharmaceuticals, Inc. (LXRX) Operating Margin (2010 - 2026)
Lexicon Pharmaceuticals' Operating Margin came in at -3835.26% for Q2 2026, down 3848.20 percentage points from 12.94% a year earlier and down 3830.54 percentage points from the prior quarter.
Lexicon Pharmaceuticals, Inc. (LXRX) Operating Margin (2010 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Lexicon Pharmaceuticals reported Operating Margin of -131.43%, up 71.15 percentage points year-over-year; for FY2025, it was -98.21%, up 536.00 percentage points from FY2024.
- Operating Margin has increased in each of the last three years, with a five-year change of +101.00 percentage points (FY2020 to FY2025).
- Going back by year, Operating Margin was -634.20% in FY2024 (+13630.75 pp), -14264.95% in FY2023 (+58224.26 pp), -72489.21% in FY2022 (-43264.38 pp) and -29224.83% in FY2021 (-29025.62 pp).
- The Q2 2026 figure represents the lowest quarterly Operating Margin since Q1 2024.
- Year-over-year, Operating Margin increased in six of the last eight quarters, with an average year-over-year change of +5058.97 percentage points.
- The fastest year-over-year change in Operating Margin over five years came in Q1 2024 (a gain of 125746.56 percentage points), and the weakest in Q4 2021 (a drop of 177180.83 percentage points).
- Business Quant data shows LXRX's Operating Margin at -4.72% (Q1 2026), -269.07% (Q4 2025) and -85.93% (Q3 2025) in the three quarters before Q2 2026.
Peer Comparison
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,835.26% |
| Mar 31, 2026 | -4.72% |
| Dec 31, 2025 | -269.07% |
| Sep 30, 2025 | -85.93% |
| Jun 30, 2025 | 12.94% |
| Mar 31, 2025 | -2,034.79% |
| Dec 31, 2024 | -123.28% |
| Sep 30, 2024 | -3,639.60% |
| Jun 30, 2024 | -3,360.90% |
| Mar 31, 2024 | -4,011.77% |
| Dec 31, 2023 | -6,657.69% |
| Sep 30, 2023 | -30,636.42% |
| Jun 30, 2023 | -13,955.84% |
| Mar 31, 2023 | -129,758.33% |
| Dec 31, 2022 | -108,135.71% |
| Sep 30, 2022 | -59,217.95% |
| Jun 30, 2022 | -68,591.43% |
| Dec 31, 2021 | -180,928.57% |
| Sep 30, 2021 | -99,834.78% |
| Jun 30, 2021 | -7,674.79% |
Lexicon Pharmaceuticals, Inc. Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=LXRX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "LXRX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=LXRX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();