Legend Biotech (LEGN) Operating Margin (2019 - 2025)
Legend Biotech (LEGN) posted Operating Margin of 6.43% for Q4 2025, up 59.69% on a QoQ basis from 15.96% in Q3 2025, and up 3609.0% year-over-year from 0.17% in Q4 2024.
Legend Biotech (LEGN) has 7 years of Operating Margin data on file, last reported at 6.43% in Q4 2025.
- In Q4 2025, Operating Margin rose 3609.0% year-over-year to 6.43%; the TTM figure through Dec 2025 stood at 54.65% (down 234.0% YoY), while the FY2025 annual figure was 13.27%, up 3607.0% from the prior year.
- Operating Margin climbed to 6.43% in Q4 2025, from 15.96% in the prior quarter.
- Across five years, Operating Margin topped out at 596.51% in Q2 2022 and bottomed at 97962.57% in Q1 2021.
- A 5-year average of 4679.86% and a median of 211.37% in 2023 frame the typical range for Operating Margin.
- Annual changes were most pronounced in 2021 — Operating Margin tumbled 9845134 bps — and 2022, when it jumped 9820825 bps.
- Year by year, Operating Margin stood at 230.36% in 2021, then soared by 72 bps to 395.35% in 2022, then sank by 75 bps to 100.0% in 2023, then slumped by 143 bps to 42.52% in 2024, then jumped by 85 bps to 6.43% in 2025.
- The last three Operating Margin figures came in at 6.43% (Q4 2025), 15.96% (Q3 2025), and 132.48% (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | - |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -6.43% |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | - |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 38.10% |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 17.83% |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 23.02% |
| 10 | Revolution Medicines | 32.39 Bn | 32.39 Bn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -6.43% |
| Sep 30, 2025 | -15.96% |
| Jun 30, 2025 | 132.48% |
| Mar 31, 2025 | 147.38% |
| Dec 31, 2024 | -42.52% |
| Sep 30, 2024 | -43.92% |
| Jun 30, 2024 | 163.22% |
| Mar 31, 2024 | 215.62% |
| Dec 31, 2023 | 100.00% |
| Sep 30, 2023 | 207.13% |
| Jun 30, 2023 | 239.25% |
| Mar 31, 2023 | 345.32% |
| Dec 31, 2022 | 395.35% |
| Sep 30, 2022 | 498.04% |
| Jun 30, 2022 | 596.51% |
| Mar 31, 2022 | 245.69% |
| Dec 31, 2021 | 230.36% |
| Sep 30, 2021 | 482.59% |
| Jun 30, 2021 | 475.25% |
| Mar 31, 2021 | -97,962.57% |
| Dec 31, 2020 | 227.32% |
| Sep 30, 2020 | 614.23% |
| Jun 30, 2020 | 518.26% |
| Mar 31, 2020 | 488.78% |
| Dec 31, 2019 | 381.60% |
| Sep 30, 2019 | 323.20% |
| Jun 30, 2019 | 389.65% |