International Stem Cell (ISCO) Operating Margin (2010 - 2026)
International Stem Cell (ISCO) posted Operating Margin of -1.31% for Q2 2026, down 8.13 percentage points from 6.82% a year earlier.
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Analysis
International Stem Cell (ISCO) Operating Margin (2010 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at International Stem Cell was -0.90%, up 0.04 percentage points year-over-year; for FY2025, it was -2.93%, down 2.19 percentage points from FY2024.
- Annual Operating Margin shows a five-year change of +36.60 percentage points (FY2020 to FY2025).
- In prior years, International Stem Cell's Operating Margin was -0.75% in FY2024 (+7.76 pp), -8.51% in FY2023 (-6.27 pp), -2.24% in FY2022 (+24.53 pp) and -26.77% in FY2021 (+12.76 pp).
- Quarterly Operating Margin has run from a low of -33.82% in Q3 2021 to a high of 6.82% in Q2 2025 over five years.
- On a year-over-year basis, Operating Margin increased in four of the last seven quarters, with an average year-over-year change of +1.05 percentage points.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q1 2022, with a gain of 35.44 percentage points; the weakest was Q4 2023, with a drop of 24.96 percentage points.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | International Stem Cell | 2.80 Mn | -1.17 Mn | 1.46 Mn | -1.31% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -1.31% |
| Dec 31, 2025 | -14.52% |
| Sep 30, 2025 | 3.97% |
| Jun 30, 2025 | 6.82% |
| Mar 31, 2025 | -10.10% |
| Dec 31, 2024 | 2.09% |
| Sep 30, 2024 | -4.13% |
| Jun 30, 2024 | 6.39% |
| Mar 31, 2024 | -8.36% |
| Dec 31, 2023 | -22.45% |
| Sep 30, 2023 | -4.92% |
| Jun 30, 2023 | -7.82% |
| Mar 31, 2023 | 0.10% |
| Dec 31, 2022 | 2.51% |
| Sep 30, 2022 | -17.62% |
| Jun 30, 2022 | 1.53% |
| Mar 31, 2022 | 1.24% |
| Dec 31, 2021 | -17.53% |
| Sep 30, 2021 | -33.82% |
| Jun 30, 2021 | -22.15% |
API Access
International Stem Cell Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=ISCO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "ISCO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=ISCO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();