HCW Biologics (HCWB) Operating Margin (2022 - 2025)
HCW Biologics' (HCWB) quarterly Operating Margin came in at 16519.15% in Q4 2025, down 1572192.0% YoY from N/an in Q4 2024, and up 21.69% on a QoQ basis from 21095.26% in Q3 2025.
HCW Biologics (HCWB) Operating Margin (2022 - 2025) Analysis & Trends
HCW Biologics (HCWB) has 4 years of Operating Margin data on file, last reported at 16519.15% in Q4 2025.
- Quarterly Operating Margin fell 1572192.0% year-over-year to 16519.15% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 24310.5% (down 2316270.0% YoY) and the FY2025 annual result came in at 24270.74%, down 2312314.0% from the prior year.
- Operating Margin advanced to 16519.15% in Q4 2025, from 21095.26% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 60.33% in Q1 2022 to a low of 52886.67% in Q2 2025.
- A 4-year average of 9405.92% and a median of 805.27% in 2023 frame the typical range for Operating Margin.
- Annual changes were most pronounced in 2024 — Operating Margin surged 1213382 bps — and 2025, when it plunged 5044086 bps.
- Tracing HCWB's Operating Margin over 4 years: stood at 422.45% in 2022, then slumped by 93 bps to 813.31% in 2023, then gained by 2 bps to 797.23% in 2024, then plunged by 1972 bps to 16519.15% in 2025.
- The last three Operating Margin figures came in at 16519.15% (Q4 2025), 21095.26% (Q3 2025), and 52886.67% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 137.11 Bn | 129.26 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 84.98 Bn | 76.99 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 64.52 Bn | 59.33 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 53.23 Bn | 48.09 Bn | 52.00 Mn | -562.07% |
| 5 | BeOne Medicines | 41.23 Bn | 36.14 Bn | 1.53 Bn | 19.06% |
| 6 | Alnylam Pharmaceuticals | 30.65 Bn | 27.34 Bn | 992.69 Mn | 17.93% |
| 7 | Insmed | 27.15 Bn | 25.99 Bn | 358.27 Mn | -0.36% |
| 8 | Royalty Pharma | 26.98 Bn | 26.14 Bn | - | 19.75% |
| 9 | BioNTech SE | 26.78 Bn | 8.39 Bn | 668.28 Mn | -35.57% |
| 10 | HCW Biologics | 2.93 Mn | 2.19 Mn | -93,887.00 | -2,335.57% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -16,519.15% |
| Sep 30, 2025 | -21,095.26% |
| Jun 30, 2025 | -52,886.67% |
| Mar 31, 2025 | -38,811.49% |
| Dec 31, 2024 | -797.23% |
| Sep 30, 2024 | -864.06% |
| Jun 30, 2024 | -2,445.81% |
| Mar 31, 2024 | -665.09% |
| Dec 31, 2023 | -813.31% |
| Sep 30, 2023 | -595.23% |
| Jun 30, 2023 | -724.22% |
| Mar 31, 2023 | -12,798.92% |
| Dec 31, 2022 | -422.45% |
| Sep 30, 2022 | -222.20% |
| Jun 30, 2022 | -773.36% |
| Mar 31, 2022 | -60.33% |