Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026)
Denali Therapeutics' (DNLI) quarterly Operating Expenses came in at $137.4 million in Q1 2026, down 5.65% year-on-year from $145.6 million in Q1 2025, and little changed on a QoQ basis from $137.4 million in Q4 2025.
Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has 10 years of Operating Expenses data on file, last reported at $137.4 million in Q1 2026.
- On a quarterly basis, Operating Expenses fell 5.65% year-over-year to $137.4 million in Q1 2026; TTM through Mar 2026 was $547.1 million, a 6.19% increase from a year earlier, with the FY2025 full-year figure at $555.3 million, up 10.65% from the prior year.
- Operating Expenses for Q1 2026 stood at $137.4 million, roughly flat from $137.4 million in the prior quarter.
- Over the last five years, Operating Expenses for DNLI reached as high as $156.0 million in Q1 2023 and fell as low as $108.6 million in Q1 2022.
- Historically, Operating Expenses has averaged $127.7 million across 5 years, with a median of $129.8 million in 2024.
- Across the five-year window, Operating Expenses soared 43.55% in 2023 and fell 15.2% in 2024, its largest moves.
- Year by year, Operating Expenses stood at $115.6 million in 2022, then increased by 14.65% to $132.6 million in 2023, then slipped by 2.06% to $129.8 million in 2024, then increased by 5.79% to $137.4 million in 2025, then retreated by 0.01% to $137.4 million in 2026.
- Per Business Quant data, the three most recent Operating Expenses figures were $137.4 million in Q1 2026, $137.4 million in Q4 2025, and $137.4 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | -28.01 Mn |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 1.10 Bn |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -3.78 Mn |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 1.85 Bn |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 2.96 Bn |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | 32.68 Mn |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 2.89 Bn |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | 445.22 Mn |
| 10 | Denali Therapeutics | 4.37 Bn | 4.37 Bn | - | 137.36 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 137.36 Mn |
| Dec 31, 2025 | 137.37 Mn |
| Sep 30, 2025 | 137.43 Mn |
| Jun 30, 2025 | 134.96 Mn |
| Mar 31, 2025 | 145.58 Mn |
| Dec 31, 2024 | 129.85 Mn |
| Sep 30, 2024 | 123.19 Mn |
| Jun 30, 2024 | 116.59 Mn |
| Mar 31, 2024 | 132.25 Mn |
| Dec 31, 2023 | 132.57 Mn |
| Sep 30, 2023 | 115.06 Mn |
| Jun 30, 2023 | 123.64 Mn |
| Mar 31, 2023 | 155.96 Mn |
| Dec 31, 2022 | 115.63 Mn |
| Sep 30, 2022 | 111.05 Mn |
| Jun 30, 2022 | 113.90 Mn |
| Mar 31, 2022 | 108.64 Mn |
| Dec 31, 2021 | 89.64 Mn |
| Sep 30, 2021 | 90.88 Mn |
| Jun 30, 2021 | 84.76 Mn |