Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026)

Denali Therapeutics' (DNLI) quarterly Operating Expenses came in at $137.4 million in Q1 2026, down 5.65% year-on-year from $145.6 million in Q1 2025, and little changed on a QoQ basis from $137.4 million in Q4 2025.

Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Operating Expenses data on file, last reported at $137.4 million in Q1 2026.

  • On a quarterly basis, Operating Expenses fell 5.65% year-over-year to $137.4 million in Q1 2026; TTM through Mar 2026 was $547.1 million, a 6.19% increase from a year earlier, with the FY2025 full-year figure at $555.3 million, up 10.65% from the prior year.
  • Operating Expenses for Q1 2026 stood at $137.4 million, roughly flat from $137.4 million in the prior quarter.
  • Over the last five years, Operating Expenses for DNLI reached as high as $156.0 million in Q1 2023 and fell as low as $108.6 million in Q1 2022.
  • Historically, Operating Expenses has averaged $127.7 million across 5 years, with a median of $129.8 million in 2024.
  • Across the five-year window, Operating Expenses soared 43.55% in 2023 and fell 15.2% in 2024, its largest moves.
  • Year by year, Operating Expenses stood at $115.6 million in 2022, then increased by 14.65% to $132.6 million in 2023, then slipped by 2.06% to $129.8 million in 2024, then increased by 5.79% to $137.4 million in 2025, then retreated by 0.01% to $137.4 million in 2026.
  • Per Business Quant data, the three most recent Operating Expenses figures were $137.4 million in Q1 2026, $137.4 million in Q4 2025, and $137.4 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -28.01 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 1.10 Bn
4 NuCana 279.75 Bn 279.75 Bn - -3.78 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.85 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 2.96 Bn
7 Belite Bio 62.51 Bn 62.51 Bn - 32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 2.89 Bn
9 Revolution Medicines 37.78 Bn 37.78 Bn - 445.22 Mn
10 Denali Therapeutics 4.37 Bn 4.37 Bn - 137.36 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 137.36 Mn
Dec 31, 2025 137.37 Mn
Sep 30, 2025 137.43 Mn
Jun 30, 2025 134.96 Mn
Mar 31, 2025 145.58 Mn
Dec 31, 2024 129.85 Mn
Sep 30, 2024 123.19 Mn
Jun 30, 2024 116.59 Mn
Mar 31, 2024 132.25 Mn
Dec 31, 2023 132.57 Mn
Sep 30, 2023 115.06 Mn
Jun 30, 2023 123.64 Mn
Mar 31, 2023 155.96 Mn
Dec 31, 2022 115.63 Mn
Sep 30, 2022 111.05 Mn
Jun 30, 2022 113.90 Mn
Mar 31, 2022 108.64 Mn
Dec 31, 2021 89.64 Mn
Sep 30, 2021 90.88 Mn
Jun 30, 2021 84.76 Mn