Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026)
Denali Therapeutics (DNLI) reported Operating Expenses of $137.4 million for Q1 2026, down 5.65% year-over-year from $145.6 million in Q1 2025, and little changed quarter-over-quarter from $137.4 million in Q4 2025.
Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has 10 years of Operating Expenses data on file, last reported at $137.4 million in Q1 2026.
- Operating Expenses for Q1 2026 came in at $137.4 million, down 5.65% year-over-year; the trailing twelve-month figure through Mar 2026 was $547.1 million (up 6.19% YoY), and the FY2025 annual result was $555.3 million, up 10.65% from the prior year.
- Operating Expenses steadied at $137.4 million in Q1 2026 per DNLI's latest filing, from $137.4 million in the prior quarter.
- Over five years, Operating Expenses peaked at $156.0 million in Q1 2023 and troughed at $108.6 million in Q1 2022.
- A 5-year average of $127.7 million and a median of $129.8 million in 2024 frame the typical range for Operating Expenses.
- The sharpest annual moves came in 2023 and 2024: Operating Expenses surged 43.55% in 2023, then decreased 15.2% in 2024.
- A 5-year view of Operating Expenses shows it stood at $115.6 million in 2022, then advanced by 14.65% to $132.6 million in 2023, then fell by 2.06% to $129.8 million in 2024, then advanced by 5.79% to $137.4 million in 2025, then dropped by 0.01% to $137.4 million in 2026.
- Business Quant data shows DNLI's Operating Expenses at $137.4 million in Q1 2026, $137.4 million in Q4 2025, and $137.4 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | 4.33 Mn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | 32.68 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 2.97 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -138.30 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | 15.76 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | 574,669.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.85 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -67.40 Mn |
| 10 | Denali Therapeutics | 4.35 Bn | 4.35 Bn | - | 137.36 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 137.36 Mn |
| Dec 31, 2025 | 137.37 Mn |
| Sep 30, 2025 | 137.43 Mn |
| Jun 30, 2025 | 134.96 Mn |
| Mar 31, 2025 | 145.58 Mn |
| Dec 31, 2024 | 129.85 Mn |
| Sep 30, 2024 | 123.19 Mn |
| Jun 30, 2024 | 116.59 Mn |
| Mar 31, 2024 | 132.25 Mn |
| Dec 31, 2023 | 132.57 Mn |
| Sep 30, 2023 | 115.06 Mn |
| Jun 30, 2023 | 123.64 Mn |
| Mar 31, 2023 | 155.96 Mn |
| Dec 31, 2022 | 115.63 Mn |
| Sep 30, 2022 | 111.05 Mn |
| Jun 30, 2022 | 113.90 Mn |
| Mar 31, 2022 | 108.64 Mn |
| Dec 31, 2021 | 89.64 Mn |
| Sep 30, 2021 | 90.88 Mn |
| Jun 30, 2021 | 84.76 Mn |