Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026)

Denali Therapeutics (DNLI) reported Operating Expenses of $137.4 million for Q1 2026, down 5.65% year-over-year from $145.6 million in Q1 2025, and little changed quarter-over-quarter from $137.4 million in Q4 2025.

Denali Therapeutics (DNLI) Operating Expenses (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Operating Expenses data on file, last reported at $137.4 million in Q1 2026.

  • Operating Expenses for Q1 2026 came in at $137.4 million, down 5.65% year-over-year; the trailing twelve-month figure through Mar 2026 was $547.1 million (up 6.19% YoY), and the FY2025 annual result was $555.3 million, up 10.65% from the prior year.
  • Operating Expenses steadied at $137.4 million in Q1 2026 per DNLI's latest filing, from $137.4 million in the prior quarter.
  • Over five years, Operating Expenses peaked at $156.0 million in Q1 2023 and troughed at $108.6 million in Q1 2022.
  • A 5-year average of $127.7 million and a median of $129.8 million in 2024 frame the typical range for Operating Expenses.
  • The sharpest annual moves came in 2023 and 2024: Operating Expenses surged 43.55% in 2023, then decreased 15.2% in 2024.
  • A 5-year view of Operating Expenses shows it stood at $115.6 million in 2022, then advanced by 14.65% to $132.6 million in 2023, then fell by 2.06% to $129.8 million in 2024, then advanced by 5.79% to $137.4 million in 2025, then dropped by 0.01% to $137.4 million in 2026.
  • Business Quant data shows DNLI's Operating Expenses at $137.4 million in Q1 2026, $137.4 million in Q4 2025, and $137.4 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Denali Therapeutics 4.35 Bn 4.35 Bn - 137.36 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 137.36 Mn
Dec 31, 2025 137.37 Mn
Sep 30, 2025 137.43 Mn
Jun 30, 2025 134.96 Mn
Mar 31, 2025 145.58 Mn
Dec 31, 2024 129.85 Mn
Sep 30, 2024 123.19 Mn
Jun 30, 2024 116.59 Mn
Mar 31, 2024 132.25 Mn
Dec 31, 2023 132.57 Mn
Sep 30, 2023 115.06 Mn
Jun 30, 2023 123.64 Mn
Mar 31, 2023 155.96 Mn
Dec 31, 2022 115.63 Mn
Sep 30, 2022 111.05 Mn
Jun 30, 2022 113.90 Mn
Mar 31, 2022 108.64 Mn
Dec 31, 2021 89.64 Mn
Sep 30, 2021 90.88 Mn
Jun 30, 2021 84.76 Mn