Crinetics Pharmaceuticals (CRNX) Operating Margin (2017 - 2026)
Crinetics Pharmaceuticals (CRNX) posted Operating Margin of -527.35% for Q2 2026, up 11995.64 percentage points from -12522.99% a year earlier and up 780.44 percentage points from the prior quarter.
Crinetics Pharmaceuticals (CRNX) Operating Margin (2017 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Crinetics Pharmaceuticals was -1302.52%, up 29089.65 percentage points year-over-year; for FY2025, it came in at -6714.77%, up 25898.70 percentage points from FY2024.
- Annual Operating Margin shows a five-year change of +98852.83 percentage points (FY2020 to FY2025).
- In prior years, Crinetics Pharmaceuticals' Operating Margin was -32613.47% in FY2024 (-27066.30 pp), -5547.17% in FY2023 (-2003.11 pp), -3544.06% in FY2022 (+6446.85 pp) and -9990.91% in FY2021 (+95576.70 pp).
- The Q2 2026 figure stands as the highest quarterly Operating Margin since Q4 2017.
- On a year-over-year basis, Operating Margin increased in three of the last four quarters, with an average year-over-year change of +7600.35 percentage points.
- The strongest year-over-year quarter for Operating Margin in the past five years was Q1 2026, with a gain of 29552.32 percentage points; the weakest was Q1 2025, with a drop of 19371.20 percentage points.
- According to Business Quant data, Operating Margin for the three prior quarters was -1307.79% (Q1 2026), -2169.55% (Q4 2025) and -99710.49% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Crinetics Pharmaceuticals | 8.99 Bn | 8.99 Bn | 24.96 Mn | -527.35% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -527.35% |
| Mar 31, 2026 | -1,307.79% |
| Dec 31, 2025 | -2,169.55% |
| Sep 30, 2025 | -99,710.49% |
| Jun 30, 2025 | -12,522.99% |
| Mar 31, 2025 | -30,860.11% |
| Jun 30, 2024 | -20,747.62% |
| Mar 31, 2024 | -11,488.91% |
| Sep 30, 2023 | -17,045.38% |
| Jun 30, 2023 | -5,363.87% |
| Mar 31, 2023 | -1,790.89% |
| Dec 31, 2022 | -6,707.48% |
| Sep 30, 2022 | -9,487.77% |
| Jun 30, 2022 | -9,805.24% |
| Mar 31, 2022 | -1,080.39% |
| Dec 31, 2021 | -2,865.31% |
| Mar 31, 2020 | -25,045.07% |
| Dec 31, 2019 | -4,739.56% |
| Sep 30, 2019 | -3,015.64% |
| Mar 31, 2019 | -2,736.78% |
Crinetics Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=CRNX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "CRNX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=CRNX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();