Curis (CRIS) Operating Margin (2010 - 2025)
Curis' (CRIS) quarterly Operating Margin came in at 1723.99% in Q4 2025, up 199287.0% YoY from N/an in Q4 2024, and up 890.78% on a QoQ basis from 218.01% in Q3 2025.
Curis (CRIS) Operating Margin (2010 - 2025) Analysis & Trends
Curis (CRIS) has 16 years of Operating Margin data on file, last reported at 1723.99% in Q4 2025.
- Quarterly Operating Margin rose 199287.0% year-over-year to 1723.99% in Q4 2025, while the trailing twelve-month figure through Mar 2026 was 100.17% (up 27682.0% YoY) and the FY2025 annual result came in at 60.5%, up 34784.0% from the prior year.
- Operating Margin improved to 1723.99% in Q4 2025, from 218.01% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 1723.99% in Q4 2025 to a low of 735.68% in Q1 2022.
- A 5-year average of 332.6% and a median of 431.67% in 2025 frame the typical range for Operating Margin.
- Annual changes were most pronounced in 2022 — Operating Margin slumped 33367 bps — and 2025, when it soared 199287 bps.
- Tracing CRIS's Operating Margin over 5 years: stood at 400.86% in 2021, then grew by 12 bps to 354.0% in 2022, then fell by 28 bps to 452.49% in 2023, then jumped by 41 bps to 268.88% in 2024, then surged by 741 bps to 1723.99% in 2025.
- The last three Operating Margin figures came in at 1723.99% (Q4 2025), 218.01% (Q3 2025), and 300.15% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.95 Bn | 132.10 Bn | 2.84 Bn | 37.40% |
| 2 | Regeneron Pharmaceuticals | 86.71 Bn | 78.72 Bn | 3.93 Bn | 30.15% |
| 3 | Argenx Se | 65.71 Bn | 60.52 Bn | 1.37 Bn | 32.54% |
| 4 | Moderna | 60.45 Bn | 55.31 Bn | 52.00 Mn | -562.07% |
| 5 | BeOne Medicines | 42.24 Bn | 37.14 Bn | 1.53 Bn | 19.06% |
| 6 | Alnylam Pharmaceuticals | 31.80 Bn | 28.49 Bn | 992.69 Mn | 17.93% |
| 7 | BioNTech SE | 28.64 Bn | 10.25 Bn | 668.28 Mn | -35.57% |
| 8 | Insmed | 27.61 Bn | 26.45 Bn | 358.27 Mn | -0.36% |
| 9 | Royalty Pharma | 27.26 Bn | 26.42 Bn | - | 19.75% |
| 10 | Curis | 3.48 Mn | -2.14 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 1,723.99% |
| Sep 30, 2025 | -218.01% |
| Jun 30, 2025 | -300.15% |
| Mar 31, 2025 | -426.76% |
| Dec 31, 2024 | -268.88% |
| Sep 30, 2024 | -360.53% |
| Jun 30, 2024 | -491.44% |
| Mar 31, 2024 | -597.75% |
| Dec 31, 2023 | -452.49% |
| Sep 30, 2023 | -436.57% |
| Jun 30, 2023 | -552.48% |
| Mar 31, 2023 | -506.18% |
| Dec 31, 2022 | -354.00% |
| Sep 30, 2022 | -446.23% |
| Jun 30, 2022 | -629.38% |
| Mar 31, 2022 | -735.68% |
| Dec 31, 2021 | -400.86% |
| Sep 30, 2021 | -330.64% |
| Jun 30, 2021 | -465.88% |
| Mar 31, 2021 | -402.01% |