BioNTech SE (BNTX) Operating Margin (2018 - 2025)
BioNTech SE (BNTX) reported Operating Margin of 35.57% for Q4 2025, down 4806.0% on a YoY basis from 0.76% in Q4 2024, and down 1052.1% sequentially from 3.09% in Q3 2025.
BioNTech SE (BNTX) Operating Margin (2018 - 2025) Analysis & Trends
BioNTech SE (BNTX) has 8 years of Operating Margin data on file, last reported at 35.57% in Q4 2025.
- For the quarter ending Q4 2025, Operating Margin fell 4806.0% year-over-year to 35.57%; the trailing twelve-month figure through Dec 2025 stood at 46.98% (up 69.0% YoY), and the FY2025 full-year result was 48.95%, down 118.0% from the prior year.
- Operating Margin slipped to 35.57% in Q4 2025, from 3.09% in the prior quarter.
- In the past five years, Operating Margin ranged from a high of 148.68% in Q2 2022 to a low of 750.74% in Q2 2024.
- A 5-year average of 52.27% and a median of 24.03% in 2023 frame the typical range for Operating Margin.
- Across the five-year window, Operating Margin sank 48458 bps in 2023 and soared 55860 bps in 2025, its largest moves.
- Tracing BNTX's Operating Margin over 5 years: stood at 84.95% in 2021, then dropped by 9 bps to 76.97% in 2022, then sank by 54 bps to 35.58% in 2023, then slumped by 65 bps to 12.49% in 2024, then slumped by 385 bps to 35.57% in 2025.
- Business Quant data shows BNTX's Operating Margin at 35.57% in Q4 2025, 3.09% in Q3 2025, and 192.14% in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 16.51% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 38.10% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 17.83% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 31.68% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | BioNTech SE | 22.13 Bn | 22.13 Bn | 668.28 Mn | -35.57% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -35.57% |
| Sep 30, 2025 | -3.09% |
| Jun 30, 2025 | -192.14% |
| Mar 31, 2025 | -292.18% |
| Dec 31, 2024 | 12.49% |
| Sep 30, 2024 | 0.84% |
| Jun 30, 2024 | -750.74% |
| Mar 31, 2024 | -270.36% |
| Dec 31, 2023 | 35.58% |
| Sep 30, 2023 | 8.16% |
| Jun 30, 2023 | -335.90% |
| Mar 31, 2023 | 51.25% |
| Dec 31, 2022 | 76.97% |
| Sep 30, 2022 | 92.20% |
| Jun 30, 2022 | 148.68% |
| Mar 31, 2022 | 85.61% |
| Dec 31, 2021 | 84.95% |
| Sep 30, 2021 | 77.60% |
| Jun 30, 2021 | 79.09% |
| Mar 31, 2021 | 81.15% |