Biocryst Pharmaceuticals (BCRX) Operating Margin (2010 - 2026)
Biocryst Pharmaceuticals (BCRX) recorded Operating Margin of 45.12% in Q2 2026, up 26.88 percentage points from 18.23% a year earlier and up 493.67 percentage points from the prior quarter.
Powered by 
Analysis
Biocryst Pharmaceuticals (BCRX) Operating Margin (2010 - 2026) Analysis & Trends
On a TTM basis, Biocryst Pharmaceuticals' Operating Margin came in at -33.29% as of Jun 30, 2026, down 43.01 percentage points year-over-year; for FY2025, it came in at 38.98%, up 39.54 percentage points from FY2024.
- Annual Operating Margin has increased for five straight years, with a five-year change of +1020.10 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -0.56% in FY2024 (+30.73 pp), -31.29% in FY2023 (+23.51 pp), -54.81% in FY2022 (+58.27 pp) and -113.08% in FY2021 (+868.04 pp).
- Quarterly Operating Margin has ranged from -448.55% in Q1 2026 to 64.05% in Q4 2025 over the past five years.
- On a year-over-year basis, Operating Margin rose in seven of the last eight quarters, with an average year-over-year change of -31.72 percentage points.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 1194.26 percentage points in Q4 2021, against a drop of 463.14 percentage points in Q1 2026 at the low end.
- Per Business Quant, the preceding three quarters came in at -448.55% (Q1 2026), 64.05% (Q4 2025) and 18.56% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Biocryst Pharmaceuticals | 2.16 Bn | 1.08 Bn | 214.41 Mn | 45.12% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 45.12% |
| Mar 31, 2026 | -448.55% |
| Dec 31, 2025 | 64.05% |
| Sep 30, 2025 | 18.56% |
| Jun 30, 2025 | 18.23% |
| Mar 31, 2025 | 14.59% |
| Dec 31, 2024 | -3.43% |
| Sep 30, 2024 | 6.57% |
| Jun 30, 2024 | 8.01% |
| Mar 31, 2024 | -15.62% |
| Dec 31, 2023 | -45.68% |
| Sep 30, 2023 | -13.74% |
| Jun 30, 2023 | -25.10% |
| Mar 31, 2023 | -41.31% |
| Dec 31, 2022 | -58.22% |
| Sep 30, 2022 | -23.01% |
| Jun 30, 2022 | -52.98% |
| Mar 31, 2022 | -100.07% |
| Dec 31, 2021 | -110.64% |
| Sep 30, 2021 | -108.76% |
API Access
Biocryst Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=BCRX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "BCRX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=BCRX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();