Alnylam Pharmaceuticals (ALNY) Operating Margin (2009 - 2026)
Alnylam Pharmaceuticals (ALNY) reported Operating Margin of 17.93% for Q2 2026, up 20.02 percentage points from -2.09% a year earlier but down 5.09 percentage points from the prior quarter.
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Analysis
Alnylam Pharmaceuticals (ALNY) Operating Margin (2009 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, Alnylam Pharmaceuticals' Operating Margin came in at 20.81%, up 27.94 percentage points year-over-year; for FY2025, it was 13.51%, up 21.37 percentage points from FY2024.
- Operating Margin has increased for seven consecutive years, with a five-year change of +181.60 percentage points (FY2020 to FY2025).
- By year, Operating Margin came in at -7.87% in FY2024 (+7.57 pp), -15.43% in FY2023 (+60.24 pp), -75.68% in FY2022 (+8.26 pp) and -83.93% in FY2021 (+84.16 pp).
- Five-year quarterly Operating Margin spans a low of -97.63% in Q3 2022 and a high of 29.46% in Q3 2025.
- Year over year, Operating Margin gained in four of the last six quarters, with an average year-over-year change of +8.33 percentage points.
- The high point for year-over-year Operating Margin in five years was Q3 2023 (a gain of 126.12 percentage points); the low point was Q3 2024 (a drop of 43.85 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at 23.02% (Q1 2026), 12.01% (Q4 2025) and 29.46% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 34.46% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 24.35% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 36.01% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 30.74% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 29.12% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 35.79% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | 41.71% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 32.98% |
| 10 | Alnylam Pharmaceuticals | 20.30 Bn | 7.49 Bn | 1.10 Bn | 23.72% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | 23.72% |
| Jun 30, 2026 | 17.93% |
| Mar 31, 2026 | 23.02% |
| Dec 31, 2025 | 12.01% |
| Sep 30, 2025 | 29.46% |
| Jun 30, 2025 | -2.09% |
| Dec 31, 2024 | -17.73% |
| Sep 30, 2024 | -15.35% |
| Jun 30, 2024 | 7.37% |
| Mar 31, 2024 | -8.79% |
| Dec 31, 2023 | -26.47% |
| Sep 30, 2023 | 28.50% |
| Jun 30, 2023 | -72.10% |
| Mar 31, 2023 | -46.92% |
| Dec 31, 2022 | -56.30% |
| Sep 30, 2022 | -97.63% |
| Jun 30, 2022 | -85.26% |
| Mar 31, 2022 | -68.80% |
| Dec 31, 2021 | -75.26% |
| Sep 30, 2021 | -96.83% |
API Access
Alnylam Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=ALNY&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "ALNY", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=ALNY&period=max&api_key=YOUR_API_KEY");
const data = await res.json();